Catalog No.
Product Name
Application
Product Information
Citations
-
DHODH Inhibitor
DHODH-IN-34 is a selective inhibitor of human dihydroorotate dehydrogenase (DHODH), exhibiting an IC50 value of 13 nM. This compound is particularly valuable for researching RNA viruses, including measles virus and chikungunya virus, due to its ability to disrupt nucleotide synthesis pathways critical for viral replication. Researchers can leverage DHODH-IN-34 to investigate therapeutic strategies against these viral infections. -
Glutamine Synthetase Inhibitor; Convulsant
L-Methionine-DL-sulfoximine is a highly specific and irreversible inhibitor of glutamine synthetase, which significantly affects astroglial metabolism and morphology. This compound also demonstrates potent convulsant properties. L-Methionine-DL-sulfoximine has been utilized in research to inhibit glutamine-dependent neuronal toxicity in vitro and to study the mechanisms underlying convulsive seizures. Additionally, it enhances the rate of fixed nitrogen release in cyanobacteria, making it a valuable tool for applications in biofertilizer research. -
Glutamine Antagonist
Duazomycin is a glutamine antagonist that plays a critical role in modulating metabolic pathways. This compound significantly enhances the efficacy of 6-Mercaptopurine in experimental allergic encephalomyelitis models, demonstrating improved therapeutic outcomes without elevating toxicity. Duazomycin is valuable for research applications focusing on metabolic interactions and therapeutic strategies in autoimmune diseases. -
Glutamine Antagonist
Duazomycin sodium is a potent glutamine antagonist that enhances the efficacy of 6-Mercaptopurine in models of experimental allergic encephalomyelitis (EAE). By targeting glutamine metabolism, it demonstrates potential to improve therapeutic outcomes while maintaining a favorable toxicity profile. This compound is valuable for research applications focused on neuroinflammatory disorders and the modulation of immune responses. -
Tyrosinase Inhibitor
Cepharadione B is a natural tyrosinase inhibitor derived from the leaves of Piper sanctum, exhibiting an IC50 value of 170 μM. This compound demonstrates significant inhibitory effects on cell growth in various cancer cell lines, including A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15. Cepharadione B is valuable for research exploring pigmentation processes, melanoma, and potential therapeutic interventions against cancer. -
Thrombin/ Factor Xa Inhibitor
Ciraparantag is a potent inhibitor of thrombin and factor Xa, serving as a broad-spectrum reversal agent for various anticoagulants. This compound effectively neutralizes the effects of low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants, while sparing vitamin K antagonists and argatroban. Its unique mechanism makes Ciraparantag a valuable tool for research focused on anticoagulation reversal and hemostasis. -
Thrombin/Factor Xa Inhibitor
Ciraparantag acetate is a potent inhibitor of thrombin and factor Xa, serving as a broad-spectrum reversal agent for various anticoagulants, including low molecular weight heparins, unfractionated heparins, and certain direct oral anticoagulants, excluding vitamin K antagonists (VKAs). Its primary mechanism targets the coagulation pathway, facilitating the restoration of normal hemostasis in clinical situations where anticoagulation reversal is necessary. Ciraparantag acetate is valuable in research applications focused on anticoagulation management and hemostatic balance in cardiovascular studies. -
Thrombin Inhibitor
Edoxaban impurity 4 is a structural impurity related to Edoxaban, a selective and potent thrombin inhibitor. It demonstrates significant biological activity and is primarily utilized in research applications focusing on anticoagulation strategies. Edoxaban itself serves as an effective anticoagulant, with its mechanistic role in inhibiting factor Xa contributing to therapeutic approaches for stroke prevention and other thromboembolic disorders. -
Thrombin/Factor Xa Inhibitor
Ciraparantag TFA is a potent thrombin and factor Xa inhibitor utilized as a broad-spectrum reversal agent for anticoagulants. It effectively antagonizes the effects of various anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and specific direct oral anticoagulants, while sparing vitamin K antagonists and argatroban. This compound is significant for research applications focused on enhancing hemostatic management in patients receiving anticoagulant therapy. -
Thrombin/Factor Xa/Trypsin/Papain Inhibitor
Bacithrocin D is a potent inhibitor of key proteases, specifically targeting thrombin, factor Xa, trypsin, and papain. It effectively prolongs clotting time, making it valuable in studies related to coagulation and hemostasis. Bacithrocin D demonstrates IC50 values of 124 μM for thrombin, 9 μM for factor Xa, 0.85 μM for trypsin, and a remarkable 0.01 μM for papain, showcasing its high potency against these proteases. This reagent is useful for investigating protease-related pathways and developing therapeutic strategies in anticoagulation research. -
Thrombin Inhibitor
Bacithrocin A is a potent thrombin inhibitor that also targets factor Xa, trypsin, and papain, demonstrating IC50 values of 48 μM, 13 μM, 0.65 μM, and 0.02 μM, respectively. This compound is of particular interest in the study of coagulation processes and the development of anticoagulant therapies. Its broad-spectrum inhibitory activity makes it a valuable reagent for biological research focused on protease activity modulation and hemostasis. -
Thrombin Inhibitor
Bacithrocin C is a potent thrombin inhibitor that effectively targets thrombin, factor Xa, trypsin, and papain, exhibiting IC50 values of 80 μM, 15 μM, 1.3 μM, and 0.02 μM, respectively. This compound demonstrates significant inhibitory activity, making it a valuable tool for research in coagulation pathways and protease-related studies. It is suitable for applications focused on understanding thrombotic processes and developing antithrombotic strategies. -
Thrombin Inhibitor
Bacithrocin B is a potent thrombin inhibitor that also targets factor Xa, trypsin, and papain. It exhibits inhibitory activity with IC50 values of 84 μM for thrombin, 17 μM for factor Xa, 1.7 μM for trypsin, and 0.02 μM for papain. This compound is valuable for research applications aiming to study coagulation processes and enzyme dynamics in various biological systems. -
Thrombin Substrate
β-Ala-Gly-Arg-pNA is a chromogenic substrate specifically designed for thrombin activity assays. It releases para-nitroaniline (pNA) upon cleavage, generating a measurable absorbance peak at 405 nm. This substrate is valuable in studies of thrombin activity and inhibition, enabling researchers to assess coagulation mechanisms and related pathological conditions accurately. -
MMP Inhibitor
Apigenin-7-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMP), demonstrating IC50 values of 12.87 µM for MMP-3, 22.39 µM for MMP-8, 17.52 µM for MMP-9, and 0.27 µM for MMP-13. This compound's ability to modulate MMP activity makes it valuable for investigations into extracellular matrix regulation, tissue remodeling, and various inflammatory conditions. Researchers may utilize Apigenin-7-glucuronide in studies aiming to explore therapeutic interventions in diseases associated with MMP dysregulation. -
MMP Inhibitor
Luteolin 7-O-glucuronide is a potent inhibitor of Matrix Metalloproteinases (MMPs), demonstrating IC50 values of 17.63 μM for MMP-1, 7.99 μM for MMP-3, 11.42 μM for MMP-8, 12.85 μM for MMP-9, and 0.03 μM for MMP-13. This compound is valuable for research investigating the regulation of MMP activity, which plays a critical role in extracellular matrix remodeling and various pathological conditions. It is suitable for applications in studies related to cancer metastasis, tissue repair, and inflammatory disorders. -
Thrombin Inhibitor
Argatroban monohydrate is a direct and selective inhibitor of thrombin. It plays a critical role in anticoagulation therapy, particularly for patients with heparin-induced thrombocytopenia. Argatroban is widely used in research to study coagulation pathways and evaluate potential therapeutic approaches for thrombotic disorders. -
Tyrosinase Inhibitor
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a potent tyrosinase inhibitor known for its ability to reduce melanin production, making it a valuable agent in skin lightening applications. This compound is of significant interest in research surrounding hyperpigmentation disorders, various cancer types, central nervous system disorders, osteoporosis, and diabetes, offering potential therapeutic insights into these conditions. Its mechanism of action provides a basis for exploring innovative treatments and understanding skin-related pathologies. -
Tyrosinase Inhibitor
Methyl cinnamate (Methyl 3-phenylpropenoate) is an effective tyrosinase inhibitor, primarily utilized to prevent enzymatic browning in food products. In addition to its role in food applications, it demonstrates antimicrobial properties and exhibits antiadipogenic effects, partly mediated by the CaMKK2-AMPK signaling pathway. This compound is valuable for researchers exploring therapeutic strategies in skin pigmentation disorders and metabolic regulation. -
Tyrosinase Inhibitor
p-Coumaric Acid Ethyl Ester serves as a non-competitive, reversible inhibitor of tyrosinase, with an IC50 value of 4.89 μg/mL and a Ki of 1.83 μg/mL. This compound quells the intrinsic fluorescence of the enzyme and alters the binding affinity of L-tyrosine by inducing conformational changes within the catalytic domain without interfering with the copper ion binding. p-Coumaric Acid Ethyl Ester has applications in the development of pharmaceuticals, cosmetics, and fruit preservation products. -
Aminopeptidase P2 Inhibitor
ST-115 is a potent inhibitor of aminopeptidase P2, a target involved in the regulation of various physiological processes. Its high specificity makes it an invaluable tool for studying the role of aminopeptidase P2 in ischemic stroke and related conditions. Researchers may utilize ST-115 to explore its potential therapeutic implications in neuroprotection and recovery following cerebral ischemia. -
Aminopeptidase A Inhibitor
Firibastat is a potent inhibitor of aminopeptidase A (APA), exhibiting a Ki value of 200 nM. This first-in-class compound effectively inhibits the conversion of brain angiotensin-II to angiotensin-III, resulting in reduced blood pressure in hypertensive models. Firibastat is particularly valuable in exploring the role of APA in neurophysiological processes and hypertension research. -
Aminopeptidase Inhibitor
L-Leucinol is a competitive inhibitor of aminopeptidase, exhibiting a Ki value of 17 μM. This reagent is primarily utilized in in vitro enzymatic assays to study enzymatic activity and inhibition. Additionally, L-Leucinol serves as a valuable tool in peptide synthesis applications, facilitating the exploration of peptide structure and function in biochemical research. -
Aminopeptidase/Epoxide Hydrolase Inhibitor
ARM1 (4BSA) is a potent inhibitor of aminopeptidase and epoxide hydrolase. It exhibits aminopeptidase inhibitory activity with an IC50 of 7.61 µM and demonstrates epoxide hydrolase inhibitory activity with an IC50 of 12.4 µM. This compound is valuable for research applications targeting metabolic pathways involving peptide and epoxide metabolism. -
Anti-inflammatory Agent, Aminopeptidase Inhibitor
2-(2'-Pyridyl)benzimidazole is an effective anti-inflammatory agent and a potent inhibitor of methionine aminopeptidase in Escherichia coli. This compound exhibits tridentate ligand properties, capable of forming stable complexes with various transition metal ions. Its applications extend to biochemical research focused on inflammatory processes and amino acid metabolism, making it a valuable reagent for studies in these areas. -
Leucine Aminopeptidase Inhibitor
Adamantanine is a potent inhibitor of leucine aminopeptidase, demonstrating an I/S0.5 value of 10.5. It effectively impairs the transport of methionine and leucine in Ehrlich ascites carcinoma cells, with a Ki value of 0.76 mM. Additionally, Adamantanine displays inhibitory effects on the proliferation of P388 lymphocytic leukemia cells, exhibiting an IC50 of greater than 1 mM. This compound serves as a valuable tool for researchers investigating amino acid transport and cancer cell proliferation. -
Neutral Endopeptidase Inhibitor, Aminopeptidase N Inhibitor
RB 101 is a mixed inhibitor of neutral endopeptidase and aminopeptidase N, enzymes that metabolize enkephalins. This compound exhibits long-lasting antinociceptive effects and inhibits in vivo [3H]DPN binding in mice under both basal conditions and after swim stress. RB 101 is particularly useful for studying the in vivo localization of enkephalinergic pathways activated by various stimuli, making it a valuable tool for pain research and neuropharmacology. -
D-aminopeptidase Substrate
H-D-Ala-D-Ala-D-Ala-D-Ala-OH is a substrate for D-aminopeptidase, an enzyme that catalyzes the cleavage of D-amino acids from peptide chains. This compound is primarily utilized in biochemical studies to investigate D-aminopeptidase activity and its role in various physiological processes. It serves as a valuable tool for researchers studying peptide metabolism and the implications of D-amino acids in biological systems. -
Aminopeptidase B Inhibitor
Arphamenine A is a potent inhibitor of aminopeptidase B, derived from Chromobacterium violaceum HMG361-CF4. This compound has demonstrated the ability to inhibit aminopeptidase B activity, contributing to its potential anticancer effects. Research indicates that Arphamenine A may suppress the growth of sarcoma 180 and invasive micropapillary carcinoma (IMC), making it a valuable tool for studying cancer biology and therapeutic strategies targeting aminopeptidase B. -
Aminopeptidase N Inhibitor
Aminopeptidase N Inhibitor 1 is a potent inhibitor targeting aminopeptidase N, demonstrating an IC50 of 25 μM. It plays a significant role in research related to tumor angiogenesis, providing valuable insights into the mechanisms of cancer progression and the development of therapeutic strategies. Its application in studies of angiogenesis makes it a crucial tool for researchers investigating tumor microenvironment interactions. -
Aminopeptidase
Aeromonas proteolytica aminopeptidase is an enzyme that acts as an aminopeptidase, catalyzing the hydrolysis of peptide bonds at the N-terminal of substrates. Additionally, this enzyme exhibits esterase activity, demonstrating the ability to hydrolyze L-leucine ethyl ester (L-Leu-OEt) with a Km value of 700 µM. Its role in protein processing and peptide metabolism makes it a valuable tool for biochemical research and enzymatic studies. -
Leukotriene A4 Hydrolase Inhibitor
JNJ-26993135 is a selective inhibitor of leukotriene A4 hydrolase (LTA4H), demonstrating an IC50 value of 11 nM. This compound is valuable for research applications focusing on inflammatory processes and leukotriene metabolism. Its ability to modulate leukotriene synthesis suggests potential use in studying various inflammatory diseases and related therapeutic interventions. -
Aminopeptidase N Inhibitor
Probestin is a potent inhibitor of aminopeptidase N (APN), derived from the bacterium Streptomyces cyanogens MH663-2F6. This compound exhibits significant biological activity by selectively blocking APN activity, leading to the modulation of various physiological processes. Probestin is valuable for research applications focused on studying the role of APN in cancer, inflammation, and immune response pathways. -
Aminopeptidase-M Inhibitor
Leuhistin is an aminopeptidase-M (AP-M) inhibitor, targeting the enzymatic degradation of bioactive peptides within cerebral membranes. By inhibiting AP-M, Leuhistin enhances the availability and activity of these peptides, making it a valuable reagent for studies focused on neurobiology and peptide research. It is derived from Bacillus laterosporus BMI156-14F1, highlighting its natural origins in biochemical applications. -
Aminopeptidase/Valine arylamidase Substrate
H-Val-βNA (L-Valine β-naphthylamide) is a substrate for aminopeptidases and valine arylamidases. It is utilized in biochemical assays to study enzyme activity and substrate specificity. The reaction of H-Val-βNA with these enzymes generates a measurable product, facilitating the investigation of enzymatic processes related to amino acid metabolism and protein turnover. -
Dipeptidylaminopeptidase Substrate
Lysine-2-naphthylamide is a substrate for dipeptidylaminopeptidase (DAP) enzymes. Its primary mechanism involves the cleavage of peptide bonds, facilitating the release of naphthylamide. This compound is useful in biochemical assays for studying DAP activity and can be employed in various research applications, including peptide hydrolysis and enzyme kinetics studies. -
Leukotriene A4 Hydrolase Inhibitor
LTA4H-IN-2 is a potent inhibitor of Leukotriene A4 Hydrolase, demonstrating an IC50 of less than 3 nM. This compound plays a crucial role in modulating inflammatory responses by inhibiting the biosynthesis of leukotrienes, which are key mediators in various inflammatory diseases. LTA4H-IN-2 is valuable for research applications focused on understanding leukotriene signaling pathways and developing therapeutics for conditions such as asthma and other inflammatory disorders. -
Aminopeptidase Inhibitor
Matlystatin A is a potent inhibitor of aminopeptidases, exhibiting IC50 values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. This compound is valuable for investigating proteolytic processes in cancer research. Its ability to modulate enzymatic activity provides insights into tumor progression and metastasis mechanisms. -
Aminopeptidase Inhibitor
Ketomethylenebestatin is a selective inhibitor of aminopeptidases, showcasing notable activity against AP-B, AP-M, and Leu-AP with IC50 values of 56 μM, 752 μM, and 0.39 μM, respectively. This compound serves as an analog of the natural aminopeptidase inhibitor Bestatin, and is valuable in research applications focused on the regulation of peptide metabolism and potential therapeutic targets in various diseases. Its specificity towards aminopeptidases makes it a useful tool for investigating enzymatic pathways and the role of these enzymes in physiological processes. -
Aminopeptidase Inhibitor
Lys-psi(CH2NH)-Trp(Nps)-OMe is a pseudodipeptide analog of lysine and tryptophan designed to inhibit aminopeptidase activity. This compound exhibits significant analgesic properties, demonstrated through dose-dependent and naloxone-reversible responses following intracerebroventricular administration in murine models. It not only prolongs analgesic effects compared to its parent compound but also offers protection against the degradation of methionine enkephalin in rat striatal slices. Lys-psi(CH2NH)-Trp(Nps)-OMe's enhanced resistance to proteolysis contributes to its sustained analgesic activity, making it a valuable tool for studying pain mechanisms and the role of aminopeptidases in neuromodulation. -
L-glutamine Analog
Azotomycin is an L-glutamine analog that exhibits antitumor activity through the modulation of cellular metabolism and signaling pathways. This compound serves as a valuable tool in cancer research, particularly in studies focusing on glutamine metabolism and its implications in tumor growth and proliferation. Researchers may utilize Azotomycin to investigate therapeutic strategies targeting glutamine-dependent cancer cells. -
L-glutamine antagonist
NSC 303861 is an L-glutamine receptor antagonist that selectively inhibits glutamine-dependent enzymes involved in purine nucleotide synthesis while sparing pyrimidine synthase. This compound exhibits significant cytotoxic effects against liver cancer 3924A cells, with an LC50 of 6 µM. NSC 303861 is valuable for cancer research, particularly in studies focused on targeting metabolic pathways in malignancies. -
μ-Calpain Inhibitor
Calpain Inhibitor-2 is a peptide inhibitor targeting μ-calpain, with a Ki value of 9 nM. This compound demonstrates significant antiproliferative activity against melanoma cell lines, specifically A-375 and B-16F1, as well as PC-3 prostate cancer cells in vitro. It is a valuable tool for research applications focused on exploring calpain-mediated pathways in cancer biology. -
Caspase-3 Activator
Ru(acac)3 (Tris(acetylacetonato)ruthenium(III)) acts as a caspase-3 activator and apoptosis inducer. This compound demonstrates growth inhibitory effects on various cell lines in vitro, primarily by inhibiting DNA/RNA synthesis and inducing a mild, reversible S-phase cell cycle arrest. Ru(acac)3 is utilized in research focused on ovarian cancer, osteosarcoma, cervical cancer, melanoma, and other oncological studies. -
PREP Inhibitor
Y-29794 is a selective, orally active inhibitor of non-peptide prolyl endopeptidase (PREP), demonstrating an IC50 of 3 nM and a Ki of 0.95 nM. It enhances the efficacy of thyrotropin-releasing hormone (TRH) on acetylcholine release in the rat hippocampus, indicating potential neuroprotective effects. Additionally, Y-29794 exhibits anticancer activity by inhibiting the IRS1-AKT-mTORC1 signaling pathway and shows the capability to penetrate the blood-brain barrier (BBB), making it valuable for various neurological and oncology research applications. -
Prolyl Endopeptidase Inhibitor
Z-Thioprolyl-Thiazolidine is a potent and selective inhibitor of prolyl endopeptidase, exhibiting a Ki value of 0.36 nM for bovine brain prolyl endopeptidase. This compound is valuable for research applications focused on peptide metabolism and neuropeptide regulation. Its specificity makes it an essential tool for studying the physiological and pathological roles of prolyl endopeptidase in various biological systems. -
POP Inhibitor
POP-IN-1 is a potent inhibitor of prolyl oligopeptidase (POP), exhibiting a Ki value of 0.009 μM. This compound demonstrates significant inhibitory activity, making it valuable for research related to neurodegenerative diseases and cancer progression. Its ability to modulate POP activity provides a valuable tool for investigating therapeutic strategies in these critical areas of study. -
Prolyl Endopeptidase (PREP) Inhibitor
Z-Pro-Pro-aldehyde-dimethyl acetal is a highly selective inhibitor of prolyl endopeptidase (PREP), a serine endoprotease located in the cytoplasm, with an IC50 value of 12 nM. This compound is vital for investigating cognitive dysfunction associated with aging and neurodegenerative diseases such as Alzheimer's disease. Its ability to modulate PREP activity makes it a valuable tool for research in neurobiology and related therapeutic areas. -
NEP Inhibitor
CGS 24592 is a selective and potent inhibitor of neutral endopeptidase 24.11 (NEP), exhibiting an IC50 value of 1.6 nmol/L. This compound effectively decreases the degradation of atrial natriuretic peptide (ANP), leading to increased plasma levels of ANP and subsequent reduction in blood pressure. CGS 24592 is valuable for research in cardiovascular diseases, particularly in the contexts of hypertension and congestive heart failure. -
PREP Inhibitor
Linderene acetate is a prolyl endopeptidase (PREP) inhibitor derived from the root of Lindera strychnifolia. This compound exhibits significant biological activity in modulating peptide metabolism and has potential applications in neurodegenerative research, where PREP plays a role in the regulation of neuropeptides. Its inhibition may offer insights into therapeutic strategies for disorders related to dysregulated peptide processing.
