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Proteases

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Items 1-50 of 1109

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Product Name
Application
Product Information
Citations
  1. A12826
    Marimastat

    MMP inhibitor

    Marimastat acted as a broad-spectrum matrix metalloproteinase inhibitor.
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  2. A11278
    PR-171 (Carfilzomib)

    Proteasome inhibitor

    PR-171 (Carfilzomib) is a tetrapeptide epoxyketone and a selective proteasome inhibitor. It is an analog of epoxomicin.
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  3. A11519
    PSI-6130

    HCV Nucleoside Inhibitor

    PSI-6130(R 1656) is a Hepatitis C Virus Nucleoside Inhibitor.
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  4. A14915
    Q-VD-OPh

    Caspase inhibitor

    Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).
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  5. A15303
    MDL 28170

    Calpain Inhibitor III

    MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.
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  6. A14396
    Telaglenastat (CB-839)

    Glutaminase inhibitor

    CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. CB-839 (Telaglenastat) also inudces autophagy and has antitumor activity.

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  7. A16317
    Z-YVAD-FMK

    Caspase-1 inhibitor

    Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
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  8. A14270
    AEBSF HCl

    serine protease inhibitor

    AEBSF HCl is a broad spectrum, irreversible serine protease inhibitor.
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  9. A12528
    Vildagliptin

    DPP-IV Inhibitor

    Vildagliptin is a dipeptidyl peptidase-4 (CD26) inhibitor.
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  10. A12444
    BMS 299897

    γ-secretase inhibitor

    BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
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  11. A12779
    Alvelestat

    neutrophil elastase inhibitor

    Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).
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  12. A11294
    Anguizole

    HCV replication Inhibitor

    Anguizole is a small molecule inhibits HCV replication and alters NS4B's subcellular distribution.
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  13. A11260
    MLN4924 (Pevonedistat)

    NAE Inhibitor

    NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
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  14. A12653
    ONX-0914

    Immunoproteasome inhibitor

    ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.
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  15. A17303
    Grazoprevir

    Hepatitis C virus NS3/4a protease inhibitor

    Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively.
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  16. A10284
    Danoprevir (RG7227)

    HCV NS3/4A protease inhibitor

    Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
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  17. A12768
    Lactacystin

    proteasome inhibitor

    Lactacystin is a cell-permeable, potent and selective proteasome inhibitor.
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  18. A11378
    Saquinavir

    HIV Protease Inhibitor

    Saquinavir is a protease inhibitor. Proteases are enzymes that cleave protein molecules into smaller fragments. Saquinavir inhibits both HIV-1 and HIV-2 proteases.
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  19. A12730
    Epoxomicin

    Proteasome inhibitor

    Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
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  20. A11224
    Linagliptin (BI-1356)

    DPP-4 Inhibitor

    Linagliptin is a DPP-4 inhibitor, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
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  21. A11043
    MG-132

    Proteasome inhibitor

    MG-132 is a potent cell-permeable inhibitor of proteasome (IC50 = 100 nM) and calpain (IC50 = 1.2 μM).
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  22. A13502
    Z-FL-COCHO (LY3000328)

    Cathepsin S inhibitor

    Z-FL-COCHO (LY3000328) is a novel Cathepsin S inhibitor.

     
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  23. A11176
    LY-411575

    Gamma secretase inhibitor

    LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.

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  24. A15479
    VCH-759

    HCV Polymerase Inhibitor

    VCH-759 is a non-nucleoside inhibitor of HCV RNA-dependent polymerase with sub-micromolar IC50 values versus genotype 1a/1b replicons.
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  25. A10802
    RO4929097

    Gamma-secretase inhibitor

    RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
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  26. A15306
    PD 150606

    Non-peptide calpain inhibitor

    PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.
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  27. A12697
    Z-DQMD-FMK

    Caspase-3 inhibitor

    Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3.
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  28. A12800
    Z-IETD-FMK

    caspase 8 inhibitor

    Z-IETD-FMK is a specific inhibitor of caspase 8.
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  29. A14358
    Z-LEHD-FMK

    Caspase-9 Inhibitor

    Z-LEHD-FMK is a synthetic peptide that irreversibly inhibits caspase-9 and related caspase activity.
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  30. A15322
    GI 254023X

    ADAM10 metalloprotease inhibitor

    GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17.
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  31. A11504
    Nelfinavir

    HIV-1 protease inhibitor

    Nelfinavir is a potent and orally bioavailable human immunodeficiency virus HIV-1 protease inhibitor (Ki=2 nM) and is widely prescribed in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.
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  32. A12778
    Lomitapide

    MTP inhibitor

    Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor.
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  33. A14293
    Trelagliptin

    DPP-4 inhibitor

    Trelagliptin is a highly selective, long-acting DPP-4 inhibitor.
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  34. A21285
    Gemigliptin

    DPP4 inhibitor

    Gemigliptin is a highly selective dipeptidyl peptidase 4 (DPP4) inhibitor with a KD of 7.25 nM.
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  35. A11109
    Saxagliptin (BMS-477118)

    DPP-4 Inhibitor

    Saxagliptin (BMS-477118) is a new dipeptidyl peptidase-4 (DPP-4) inhibitor with IC50 of 50 nM.
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  36. A13072
    NSC 405020

    MT1-MMP inhibitor

    NSC-405020 is a membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L).
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  37. A21069
    VBY-825

    cathepsin inhibitor

    VBY-825 is a novel, reversible cathepsin inhibitor with high potency against cathepsins B, L, S and V.
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  38. A11343
    Ciluprevir (BILN 2061)

    HCV NS3 protease Inhibitor

    Ciluprevir is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease.
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  39. A10902
    Telaprevir (VX-950)

    HCV NS3-4A protease inhibitor

    Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
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  40. A11295
    Asunaprevir (BMS-650032)

    NS3 protease inhibitor

    Asunaprevir is an inhibitor of the viral enzyme serine protease NS3.
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  41. A10160
    Bortezomib (Velcade)

    Proteasome inhibitor

    Bortezomib is a highly selective, reversible inhibitor of the 26S proteasome
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  42. A13593
    CA-074 Methyl Ester

    Cathepsin B inhibitor

    CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
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  43. A13503
    Z-DEVD-FMK

    Caspase-3 Inhibitor

    Z-DEVD-FMK is a specific, irreversible Caspase-3 inhibitor.
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  44. A15025
    BMS-663068 (Fostemsavir)

    HIV-1 attachment inhibitor

    BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection.
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  45. A14194
    Bevirimat

    HIV-1 maturation inhibitor

    Bevirimat (MPC-4326, PA-457, YK-FH312) is a first-in-class HIV-1 maturation inhibitor that demonstrates high potency in cell culture and has shown clinical efficacy in HIV-1-infected patients.
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  46. A11529
    Sofosbuvir (PSI-7977)

    HCV Nucleotide Inhibitor

    PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
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  47. A13155
    Ledipasvir (GS 5885)

    NS5A inhibitor

    Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein
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  48. A13259
    E 64d (Aloxistatin)

    Cysteine Protease inhibitor

    E-64d is an inhibitor of cathepsins B and L and it is lysosome and cell permeable.
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  49. A12985
    Batimastat (BB-94)

    MMP inhibitor

    Batimastat (BB-94) is a potent and synthetic inhibitor of a broad spectrum of matrix metalloproteinases (MMPs), including interstitial collagenase (IC50 = 3 nM), stromelysin (IC50 = 20 nM), Mr 72,000 type IV collagenase (IC50 = 4 nM), Mr 92,000 type IV collagenase (IC50 = 4 nM), and matrilysin (IC50 = 6 nM). It is a low-molecular-weight (MW = 478) and peptide-like collagen substrate analogue consisting of a peptide backbone and a hydroxamic acid group which bind to MMPs and the catalytically active zinc atom respectively.
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  50. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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