Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
TCO-PEG9-maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the conjugation of targeting moieties and E3 ligase recruiting units, enabling the effective degradation of selected proteins. This linker is particularly valuable in chemical biology and drug discovery research, where targeted protein degradation mechanisms are being explored for therapeutic development. -
PROTAC Linker
N-Boc-PEG8-alcohol is a polyethylene glycol (PEG) linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound enhances the solubility and stability of PROTACs, facilitating targeted protein degradation studies. Its key biological activity lies in its ability to serve as a versatile scaffold for conjugation, making it suitable for various research applications in drug discovery and development. -
PROTAC Linkers
t-Boc-Aminooxy-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, facilitating its engagement in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN groups, making it an essential tool for biochemical research and development in targeted protein degradation studies. -
PROTAC Linker
Benzyl-PEG45-alcohol is a polyethylene glycol (PEG)-based linker designed for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation of proteins within cellular systems. It is widely utilized in the synthesis of PROTACs for drug discovery and development, particularly in the study of protein homeostasis and targeted protein degradation. -
PROTAC Linkers
Br-PEG3-MS is a polyethylene glycol (PEG)-based PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of targeted protein degradation strategies, enhancing the efficacy of drug discovery and development. Its utility in connecting E3 ligases to target proteins makes Br-PEG3-MS a valuable tool for researchers exploring novel therapeutic approaches in various disease models. -
PROTAC Linker
N-Mal-N-bis(PEG4-NH-Boc) is a PEG-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). This compound facilitates the construction of PROTACs by promoting efficient cellular targeting and degradation of specific proteins. Its application is particularly valuable in advancing research in targeted protein degradation and therapeutic interventions in various diseases. -
PROTAC Linkers
Hydroxy-PEG3-acid is a polyethylene glycol (PEG) linker designed for protein degradation applications through PROTAC technology. This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the selectivity and efficacy of targeted protein degradation strategies. Its hydrophilic nature promotes solubility and improves biological compatibility, making it suitable for various research applications in drug development and protein modulation studies. -
PROTAC Linker
Benzyl-PEG8-alcohol is a polyethylene glycol (PEG)-based linker designed specifically for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of heterobifunctional molecules that promote targeted protein degradation by harnessing the ubiquitin-proteasome system. Its advantageous properties make it suitable for various biochemical applications, particularly in the development of novel therapeutics that modulate protein levels in cellular and in vivo studies. -
PROTAC Linker
Amino-PEG9-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the targeted degradation of specific proteins, enabling research into novel therapeutic pathways and protein regulation mechanisms. Its solubility properties enhance the bioavailability of PROTACs, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Bromo-PEG4-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with compounds containing alkyne functionality. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatility makes Bromo-PEG4-azide a valuable tool for researchers involved in targeted protein degradation studies. -
PROTAC Linker
Acid-PEG3-mono-methyl ester is a PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This alkyl/ether-based compound facilitates the connection between target proteins and E3 ligases, enhancing the selective degradation of specific proteins within cellular systems. Its chemical structure promotes solubility and bioavailability, making it suitable for a variety of research applications in drug discovery and development. -
PROTAC Linker
Tos-PEG3-CH2COOtBu is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of bifunctional molecules that can selectively induce the degradation of target proteins via the ubiquitin-proteasome pathway. Its application is critical in chemical biology for the development of targeted protein degradation strategies and probing protein function in various cellular contexts. -
PROTAC Linker
DBCO-PEG4-alcohol is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. Featuring a DBCO group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in the development of targeted protein degradation strategies underscores its significance in chemical biology and therapeutic research. -
PROTAC Linkers
Hydroxy-PEG2-C2-methyl ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This reagent provides solubility and flexibility, enhancing the efficacy of PROTACs in targeting specific proteins for degradation. Its suitable molecular structure facilitates the development of novel therapeutic agents aimed at modulating protein levels in various biological contexts. -
PROTAC Linkers
DBCO-PEG12-Maleimide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, enabling efficient and selective conjugation. This chemical reagent is valuable in targeted protein degradation studies and the development of novel therapeutic strategies. -
PROTAC Linkers
(2-Pyridyldithio)-PEG4-alcohol is a PEG-derived linker utilized in the design and synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a pyridyldithio group that facilitates the construction of compounds aimed at targeted protein degradation. It is suitable for various research applications that explore novel therapeutic strategies in areas such as oncology and protein regulation. -
PROTAC Linkers
Bis-aminooxy-PEG4 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the conjugation of ligands to E3 ligase to promote targeted protein degradation. Its versatility makes it valuable in chemical biology research for developing innovative therapeutic strategies that harness the ubiquitin-proteasome system. -
PROTAC Linker
Bis-PEG4-TFP ester serves as a versatile PEG-based linker for the synthesis of PROTACs (proteolysis-targeting chimeras). This molecule facilitates the formation of bifunctional compounds by linking target proteins to E3 ligases, enabling targeted degradation pathways. Its structure enhances solubility and stability, making it an essential tool for research in protein regulation and therapeutic development. -
PROTAC linker
Biotin-PEG7-azide is a polyethylene glycol (PEG)-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functional groups. Biotin-PEG7-azide is essential for the development and optimization of targeted protein degradation strategies in chemical biology research. -
PROTAC Linkers
Bis-Biotin-PEG23 is a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the construction of PROTACs by providing a flexible, biotinylated connection that enhances target protein degradation. Its unique structure enables efficient dual-targeting capabilities, making it suitable for studies in targeted protein degradation and cellular pathways. -
PROTAC Linker
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation and offers significant potential for therapeutic research in various diseases. -
PROTAC Linker
Azido-PEG11-amine is a PEG-based PROTAC linker that facilitates the synthesis of targeted protein degraders. This molecule features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) groups. Its versatile reactivity makes it a valuable tool for bioconjugation and drug discovery applications. -
PROTAC Linker
N-(Azido-PEG2)-N-Boc-PEG3-NHS ester is a PEG-based PROTAC linker designed for the effective synthesis of protein-targeting chimeras. This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkynes or DBCO/BCN groups, respectively. Its versatility allows for precise modifications in drug development and the exploration of targeted protein degradation mechanisms in biochemical research. -
PROTAC Linkers
5-endo-BCN-pentanoic acid is a versatile PROTAC linker featuring a BCN group, which enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This alkyl chain-based linker facilitates the synthesis of PROTACs, enhancing targeted protein degradation and enabling innovative therapeutic strategies. Its applications span various biological research areas, allowing for precise manipulation of protein interactions to study cellular processes. -
PROTAC Linker
Bis-PEG6-acid functions as a PEG-based linker for PROTAC (Proteolysis Targeting Chimeras) applications. This compound facilitates the synthesis of PROTACs by enabling the conjugation of ligands to E3 ligase recruiters, thereby promoting targeted degradation of proteins. Its use is essential in the development of novel therapeutics aimed at modulating protein levels in various biological contexts. -
PROTAC Linker
Bromoacetamido-PEG2-C2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis targeting chimeras). This compound enhances the efficiency of targeting and degradation of specific proteins through the hijacking of the cell's ubiquitin-proteasome system. It serves as a crucial component in the development of novel therapeutic strategies for targeted protein degradation in various fields of biomedical research. -
PROTAC Linker
Bromoacetamido-PEG2-C2-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the formation of targeted protein degradation molecules by enhancing solubility and stability. It is instrumental in the design of PROTACs aimed at modulating protein levels in various biological pathways, providing insights into cellular mechanisms and therapeutic interventions. -
PROTAC Linker
Sulfo-NHS-Acetate sodium is a reactive PROTAC linker designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTACs by providing a functional group for covalent attachment to target proteins. Its ability to enhance the efficiency of protein degradation makes it a valuable reagent in chemical biology research and drug discovery. -
PROTAC Linker
m-PEG4-CH2COOH is a PEG-based PROTAC linker designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound plays a crucial role in enhancing the solubility and biostability of the conjugated molecules, thereby improving their efficacy in targeted protein degradation. It is ideal for use in biochemical research focused on drug discovery and development within the area of targeted therapies. -
PROTAC Linker
Hydroxy-PEG2-C2-PFP ester functions as a versatile linker for PROTAC synthesis, facilitating targeted protein degradation. This PEG/alkyl/ether-based compound is designed to enhance the solubility and biocompatibility of PROTAC molecules. Its unique structure aids in the effective conjugation of various protein ligands, making it a valuable tool in chemical biology and drug discovery applications. -
PROTAC Linker
Aminooxy-PEG5-azide is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized compounds, making it a versatile tool for targeted protein degradation studies and chemical biology applications. -
PROTAC Linker
Fmoc-N-amido-PEG2-alcohol is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound enhances the solubility and stability of PROTAC molecules, facilitating targeted protein degradation in cellular assays. It serves as a valuable tool in chemical biology research, enabling the investigation of protein function and modulation through selective degradation. -
PROTAC Linker
Bis-acrylate-PEG6 is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This linker facilitates the effective conjugation of protein degradation ligands, enabling targeted protein modulation in cellular systems. Its application in the development of PROTACs supports research in targeted protein degradation and therapeutic intervention strategies. -
PROTAC Linkers
Bromo-PEG7-Boc is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates targeted protein degradation by linking a ligand to an E3 ligase, enhancing the specificity and efficacy of PROTAC molecules. Its utility in chemical biology research makes it a valuable reagent for studies focused on protein regulation and therapeutic development. -
PROTAC Linkers
m-PEG8-CH2COOH is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances solubility and stability, promoting effective target degradation pathways. It is applicable in various studies related to targeted protein degradation and the development of novel therapeutics. -
PROTAC Linkers
Tri(Amino-PEG3-amide)-amine is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It facilitates the recruitment of E3 ubiquitin ligases to target proteins for ubiquitination and subsequent proteasomal degradation. This compound is essential for the development of targeted protein degradation strategies in research applications, including drug discovery and therapeutic development. -
PROTAC Linker
Mal-amido-PEG2-TFP ester is a polyethylene glycol (PEG) derivative designed as a linker for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, enhancing the targeted degradation of specific proteins within cellular contexts. Its application is essential in the development of novel therapeutic agents aimed at mitigating diseases by promoting the selective proteolysis of target proteins. -
PROTAC Linker
1-(1,1-Dimethylethyl) tridecanedioate serves as a versatile PROTAC linker, facilitating the synthesis of heterobifunctional molecules for targeted protein degradation. Its structure contributes to the development of PROTACs by enhancing stability and solubility, thereby improving cellular uptake and efficacy. This compound is valuable for researchers exploring targeted therapeutics and protein modulation strategies in various biological systems. -
PROTAC Linker
N-Boc-N-bis(PEG4-acid) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that recruit E3 ubiquitin ligases for targeted protein degradation. Its hydrophilic nature enhances solubility and bioavailability, making it suitable for various biochemical and pharmacological applications in chemical biology research. -
PROTAC Linker
Amino-PEG7-t-butyl ester is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. Featuring an amino (NH2) group and a tert-butyl protected carboxyl moiety, this reagent facilitates the construction of PROTAC molecules that enhance targeted protein degradation. Its applications extend to drug delivery research, making it a valuable tool for developing novel therapeutic strategies. -
PROTAC Linker
Methyl 6-hydroxyhexanoate is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). Its structure facilitates the selective degradation of target proteins through recruitment of E3 ligases, enabling advanced studies in targeted protein modulation. This compound plays a crucial role in drug discovery and development, particularly in the exploration of novel therapeutic strategies for various diseases. -
PROTAC Linker
Tridecane-1,13-diol is a versatile PROTAC linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). This compound features a 13-carbon hydrocarbon backbone with hydroxyl groups at both ends, facilitating efficient conjugation of target proteins to E3 ligases. Its application in PROTAC development supports targeted degradation of proteins, enhancing research in protein modulation and therapeutic interventions in diseases driven by aberrant protein expression. -
PROTAC Linker
Benzyl (3-bromopropyl)carbamate serves as a PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs). This compound is essential for the development of novel therapeutic agents that induce selective degradation of target proteins through the ubiquitin-proteasome system. Its precise composition and structure enable effective conjugation with target proteins and E3 ligases, enhancing the potential for targeted protein modulation in various biological research applications. -
PROTAC Linker
trans-4-Cyanocyclohexane-1-carboxylic acid serves as a versatile linker in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its unique structure enhances hydrophilicity and may improve cellular permeability, making it suitable for various applications in drug discovery and the study of protein function and regulation. -
PROTAC Linker
tert-Butyl 4-cyanopiperazine-1-carboxylate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates targeted protein degradation through the recruitment of E3 ubiquitin ligases, thereby enabling the selective modulation of protein levels. Its unique structure offers versatility in designing novel PROTACs for various therapeutic applications in cellular and molecular biology research. -
PROTAC Linker
(9H-Fluoren-9-yl)methyl (4-aminobutyl)carbamate hydrochloride is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and efficacy of PROTACs by enabling targeted protein degradation. Its chemical structure supports various biological applications in drug discovery and molecular biology, particularly in the development of novel therapeutic strategies. -
PROTAC Linker
Benzyl (2-(2-aminoethoxy)ethyl)carbamate is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound serves as a crucial component in the synthesis of PROTACs, enabling researchers to efficiently target specific proteins for degradation. Its application in chemical biology allows for the exploration of targeted protein modulation and novel therapeutic strategies. -
PROTAC Linker
tert-Butyl (8-hydroxyoctyl)carbamate is a versatile PROTAC linker utilized in the design and synthesis of PROTAC molecules. It facilitates the recruitment of E3 ligases and the targeted degradation of specific proteins, making it valuable for studies in targeted protein degradation and therapeutic development. Its unique structure enhances the efficiency and selectivity of PROTAC applications in chemical biology research. -
PROTAC Linker
N-Boc-Piperidin-4-yl-acetic acid methyl ester serves as a PROTAC linker that plays a crucial role in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins for ubiquitination and subsequent degradation. Its unique structure enables effective linkages that enhance target specificity and efficacy in cellular environments. Researchers utilize this reagent to develop innovative therapeutic strategies for the selective modulation of protein levels in biological systems. -
PROTAC Linker
Dde Biotin-PEG4-azide is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry. This reagent features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can facilitate strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds. Its applications are particularly valuable in chemical biology for targeted protein degradation studies and related research endeavors.
