Fig. 1 · Structure
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Lenalidomide 4'-PEG2-azide
Ligands for E3 Ligase
Lenalidomide 4'-PEG2-azide is a Lenalidomide-derived ligand that targets Cereblon, facilitating the recruitment of CRBN protein. This compound can be utilized to create PROTACs by linking it to various proteins, thereby enabling targeted protein degradation and advancing research in drug development and cellular regulation. Its use is relevant in the study of E3 ligase-mediated pathways and therapeutic strategies in oncology and immunology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2399455-48-0 |
| Applications | Ligands for E3 Ligase |
| Formula | C19H24N6O5 |
| Molecular Weight | 416.43 |
| SMILES | [N-]=[N+]=NCCOCCOCCNC1=CC=CC2=C1CN(C3C(NC(CC3)=O)=O)C2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.