Fig. 1 · Structure
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Bis(2,5-dioxopyrrolidin-1-yl) succinate
PROTAC Linker
Bis(2,5-dioxopyrrolidin-1-yl) succinate serves as a versatile PROTAC linker, facilitating the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the precision and efficacy of targeted protein degradation by promoting the recruitment of E3 ubiquitin ligases to specific protein targets. Its application in chemical biology allows for the investigation of protein dynamics and modulation of cellular pathways for therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 30364-60-4 |
| Applications | PROTAC Linker |
| Formula | C12H12N2O8 |
| Molecular Weight | 312.23 |
| SMILES | O=C(ON1C(=O)CCC1=O)CCC(=O)ON2C(=O)CCC2=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.