BTK

Inhibitory Selectivity
Catalog No.Inhibitor Name BTKOther
A11020Ibrutinib
****
BLK,Bmx,FGR
A13202AVL-292
****
YES,c-Src,BRK
A13233CNX-774
***
A15558ONO-4059 analogue
**
A16261LFM-A13
*
A12535RN486
**
A11348CGI1746
***
A12706GDC-0834
**
A15008AVL-292 benzenesulfonate
****
YES,c-Src,BRK
A15824ACP-196 (Acalabrutinib)
**
A15976Olmutinib (HM71224)
***
A16262PCI 29732
**
A16263QL47
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15824 SALE

ACP-196 (Acalabrutinib)

Btk Inhibitor
ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.
A13202 SALE

AVL-292

Btk inhibitor
AVL-292 is a highly selective, covalent Btk inhibitor.
A15008

AVL-292 benzenesulfonate

BTK inhibitor
AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed.
A16260

Btk inhibitor 1

BTK inhibitor
Btk inhibitor 1 is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor.
A11348 SALE

CGI1746

BTK inhibitor
CGI1746 is a small-molecule Btk inhibitor chemotype with a new binding mode that stabilizes an inactive nonphosphorylated enzyme conformation.
A13233 SALE

CNX-774

BTK Inhibitor
CNX-774 is a potent Btk inhibitor (IC50 < 1 nM)
A12706

GDC-0834

BTK inhibitor
GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis.
A16261

LFM-A13

BTK inhibitor
LFM-A13 is a potent and selective inhibitor of Btk with IC50 of 17.2 uM; also inhibits PLK3 with IC50 of 7.2 uM.
A15976

Olmutinib (HM71224)

BTK inhibitor
Olmutinib is a potent small molecule inhibitor of Bruton's tyrosine kinase (BTK).
A15558 SALE

ONO-4059

BTK inhibitor
ONO-4059 is a highly potent and selective oral BTK inhibitor
A16262

PCI 29732

BTK inhibitor
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
A11020 SALE

PCI-32765

Bruton tyrosine kinase inhibitor
PCI-32765 is an orally bioavailable small-molecule inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.
A16263

QL47

BTK inhibitor
QL47 is a potent, selective and irreversible BTK kinase inhibitor with IC50 of 7 nM.

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