AVL-292

Catalog No.: A13202

Btk inhibitor

AVL-292

AVL-292 Chemical Structure

CAS NO. 1202757-89-8

AVL-292 is a highly selective, covalent Btk inhibitor.

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$90.00
25 mg
$170.00
50 mg
$260.00
10mM * 1mL in DMSO
$65.00
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Biological Activity

AVL-292 is a highly selective, covalent Btk inhibitor.
Targets
Target Value
BTKIC50: <0.5nM
YESIC50: 723nM
c-SrcIC50: 1.729μM
BRKIC50: 2.43μM
LynIC50: 4.401μM
FynIC50: 7.146μM
LCKIC50: 9.079μM
CSKIC50: >10μM
HckIC50: 14.46μM
In vitro DMSO 78 mg/mL (184.2 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.62 mL 118.08 mL 236.16 mL
0.5 mM 4.72 mL 23.62 mL 47.23 mL
1 mM 2.36 mL 11.81 mL 23.62 mL
5 mM 0.47 mL 2.36 mL 4.72 mL

*The above data is based on the productmolecular weight 423.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13202
Actions Inhibitor
CAS No. 1202757-89-8
Formula C22H22FN5O3
M. Wt 423.44
Purity >98%
Synonyms AVL292, AVL 292, CC292, CC-292, CC 292
SMILES COCCOC1=CC=C(C=C1)NC2=NC=C(C(=N2)NC3=CC(=CC=C3)NC(=O)C=C)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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