p53

Actions
  1. Activator (11)
  2. Inducer (1)
  3. Inhibitor (4)


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Catalog No. Product Name Application Product Information
A10491

JNJ 26854165

p53 activator
JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
A15348

MIRA-1

p53 inducer
MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA.
A15349

NSC 146109 hydrochloride

p53 activator
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription.
A12930

NSC 319726

p53R175 activator
NSC 319726 is a potent and selective activator of mutant p53R175
A13413

NSC59984

P53 Activator
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
A15201

p53 and MDM2 proteins-interaction-inhibitor chiral

-
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
A15202

p53 and MDM2 proteins-interaction-inhibitor racemic

-
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
A15350

PhiKan 083

p53 stabilizer
PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions.
A12451

Pifithrin-alpha

p53 inhibitor
Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
A12450

Pifithrin-beta

p53 Inhibitor
Pifithrin-beta is a small molecule inhibitor of p53.
A12449

Pifithrin-u

p53 inhibitor
inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
A13581

PRIMA-1

p53 reactivator
PRIMA-1 is a small molecule identified for its p53 reactivating effect.
A15351

RETRA hydrochloride

mutant p53 Reactivator
RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo.
A11523

RG7112

selective p53-MDM2 inhibitor
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
A11931

RITA (NSC 652287)

p53 activator
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
A15352

SJ 172550

MDMX inhibitor
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
A11943

Tenovin-1

p53 activator
Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation.
A13727

Tenovin-3

p53 activator
N/A
A12305

Tenovin-6

p53 activator
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
A15353

WR 1065

P53/p21waf-1/MDM2 activator
WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.

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