p53



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Catalog No. Product Name Application Product Information
A15201

p53 and MDM2 proteins-interaction-inhibitor chiral

p53-MDM2 interaction inhibitor
p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins.
A15202

p53 and MDM2 proteins-interaction-inhibitor racemic

p53-MDM2 interaction inhibitor
p53 and MDM2 proteins-interaction-inhibitor racemic is an inhibitor of the interaction between p53 and MDM2 proteins.
A15348

MIRA-1

p53 inducer
MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA.
A12305 SALE

Tenovin-6

p53 activator
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
A15349

NSC 146109 hydrochloride

p53 activator
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription.
A15350

PhiKan 083

p53 stabilizer
PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions.
A12930 SALE

NSC 319726

p53R175 activator
NSC 319726 is a potent and selective activator of mutant p53R175
A15351

RETRA hydrochloride

mutant p53 Reactivator
RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo.
A12449

Pifithrin-u

p53 inhibitor
inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL.
A15352

SJ 172550

MDMX inhibitor
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
A12451 SALE

Pifithrin-alpha

p53 inhibitor
Pifithrin-a is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression.
A15353

WR 1065

P53/p21waf-1/MDM2 activator
WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.
A15346

CP 31398 dihydrochloride

p53 stabilizer
CP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
A13413

NSC59984

P53 Activator
NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 uM for p53-null HCT116 cells.
A10491 SALE

JNJ 26854165

p53 activator
JNJ-26854165 is one of p53-activating agents and synergizes with AraC or doxorubicin to induce p53-mediated apoptosis and may provide a novel therapeutic approach for the treatment of acute leukemias.
A13522

CP 31398 2HCl

p53 stabilizer
CP 31398 2HCl has been shown to act as a stabilizing agent for p53, and to promotes activity of p53 in cancer cell lines.
A11931 SALE

RITA (NSC 652287)

p53 activator
RITA, also referred to as NSC 652287, is a trycyclic thiophene derivative that binds to MDM2, disrupting the MDM2-p53 complex and subsequently activating p53 and inducing apoptosis.
A11943

Tenovin-1

p53 activator
Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation.
A12450 SALE

Pifithrin-beta

p53 Inhibitor
Pifithrin-beta is a small molecule inhibitor of p53.
A13117

NSC348884

nucleophosmin inhibitor
NSC348884 is a nucleolar phosphoprotein that displays several biological activities in ribosome biogenesis, cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, and centrosome duplication. NSC 348884 is a putative inhibitor of nucleophosmin (NPM). NSC 348884 inhibits NMP oligomer formation, up-regulates p53 and induces apoptosis.
A13581

PRIMA-1

p53 reactivator
PRIMA-1 is a small molecule identified for its p53 reactivating effect.
A13727

Tenovin-3

p53 activator
N/A
A13797

Kevetrin HCl

-
Kevetrin (thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
A13636 SALE

APR-246

-
APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity.
A11523

RG7112

selective p53-MDM2 inhibitor
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

25 Item(s)

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