Catalog No.: A11523

selective p53-MDM2 inhibitor


RG7112 Chemical Structure

CAS NO. 939981-39-2

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

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Biological Activity

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.
In vitro (25°C) DMSO 97 mg/mL (133.55 mM)
Water Insoluble
Ethanol 97 mg/mL (133.55 mM)
In vivo 1% CMC Na 13 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.74 mL 68.7 mL 137.4 mL
0.5 mM 2.75 mL 13.74 mL 27.48 mL
1 mM 1.37 mL 6.87 mL 13.74 mL
5 mM 0.27 mL 1.37 mL 2.75 mL

*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11523
Actions Inhibitor
CAS No. 939981-39-2
Formula C38H48Cl2N4O4S
M. Wt 727.78
Purity >98%
Synonyms RG-7112, RG 7112, RO5045337

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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