RG7112

Name: RG7112
SKU: A11523
Price: 120 USD
Rating: 5 (288 reviews)

Catalog No.: A11523

selective p53-MDM2 inhibitor

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

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Grouped product items
Size	Price	Stock
5mg	$120.00	In stock
10mg	$210.00	In stock
50mg	$640.00	In stock
Bulk Size	Bulk Discount

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Data Sheet

SDS

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Biological Activity

Discription	RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

Product Information

Catalog Num	A11523
Formula	C38H48Cl2N4O4S
Molecular Weight	727.78
CAS Number	939981-39-2
SMILES	CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl
Synonyms	RG-7112, RG 7112, RO5045337
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	97 mg/mL (133.55 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (133.55 mM)
In vivo	1% CMC Na	13 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.74 mL	68.7 mL	137.4 mL
0.5 mM	2.75 mL	13.74 mL	27.48 mL
1 mM	1.37 mL	6.87 mL	13.74 mL
5 mM	0.27 mL	1.37 mL	2.75 mL

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