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Publications citing Adooq Products
Chemical Information
| Catalog Num | A11523 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 727.78 |
| Formula | C38H48Cl2N4O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 939981-39-2 |
| Synonyms | RG-7112, RG 7112, RO5045337 |
| SMILES code | CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl |
| Chemical Name | [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethylimidazol-1-yl]-[4-(3-methylsulfonylpropyl)piperazin-1-yl]methanone |
Description |
RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. | |||||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.74 mL | 68.7 mL | 137.4mL |
| 0.5 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 1 mM | 1.37 mL | 6.87 mL | 13.74 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.75 mL |
*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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