Signaling Pathway
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| Discription | RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2. | |||||
|---|---|---|---|---|---|---|
| Cell Research |
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| Catalog Num | A11523 |
|---|---|
| Formula | C38H48Cl2N4O4S |
| Molecular Weight | 727.78 |
| CAS Number | 939981-39-2 |
| SMILES | CCOC1=C(C=CC(=C1)C(C)(C)C)C2=NC(C(N2C(=O)N3CCN(CC3)CCCS(=O)(=O)C)(C)C4=CC=C(C=C4)Cl)(C)C5=CC=C(C=C5)Cl |
| Synonyms | RG-7112, RG 7112, RO5045337 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 97 mg/mL (133.55 mM) | |
| Water | Insoluble | ||
| Ethanol | 97 mg/mL (133.55 mM) | ||
| In vivo | 1% CMC Na | 13 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.74 mL | 68.7 mL | 137.4 mL |
| 0.5 mM | 2.75 mL | 13.74 mL | 27.48 mL |
| 1 mM | 1.37 mL | 6.87 mL | 13.74 mL |
| 5 mM | 0.27 mL | 1.37 mL | 2.75 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
