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selective p53-MDM2 inhibitor

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Catalog No. A11523

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
RG7112 5mg A11523-5
RG7112 10mg A11523-10
RG7112 50mg A11523-50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.


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Chemical Information

Catalog Num A11523
Actions Inhibitor
M. Wt 727.78
Formula C38H48Cl2N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 939981-39-2
Synonyms RG-7112, RG 7112, RO5045337

Biological Activity

RG7112 is the first clinical small-molecule MDM2 inhibitor designed to occupy the p53-binding pocket of MDM2.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.74 mL 68.7 mL 137.4mL
0.5 mM 2.75 mL 13.74 mL 27.48 mL
1 mM 1.37 mL 6.87 mL 13.74 mL
5 mM 0.27 mL 1.37 mL 2.75 mL

*The above data is based on the productmolecular weight 727.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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