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Biological Activity
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.32 mL | 116.59 mL | 233.17 mL |
| 0.5 mM | 4.66 mL | 23.32 mL | 46.63 mL |
| 1 mM | 2.33 mL | 11.66 mL | 23.32 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
*The above data is based on the productmolecular weight 428.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15352 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 431979-47-4 |
| Formula | C22H21ClN2O5 |
| M. Wt | 428.87 |
| Purity | >98% |
| Synonyms | SJ172550, SJ-172550 |
| SMILES | CCOC1=C(C(=CC(=C1)C=C2C(=NN(C2=O)C3=CC=CC=C3)C)Cl)OCC(=O)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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