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Chemical Information
Catalog Num | A11943 |
---|---|
Actions | Activator |
M. Wt | 369.5 |
Formula | C20H23N3O2S |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 380315-80-0 |
Synonyms | N/A |
SMILES code | CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C |
Chemical Name | N-?[[[4-?(acetylamino)phenyl]amino]thioxomethyl-?4-?(1,?1-?dimethylethyl)]-?benzamide |
Description |
Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation. | ||||||||||
Targets |
|
Solubility (25°C) * | In vitro | DMSO | 74 mg/mL (200.28 mM) |
---|---|---|---|
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 15% Captisol | 15 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 27.06 mL | 135.32 mL | 270.64mL |
0.5 mM | 5.41 mL | 27.06 mL | 54.13 mL |
1 mM | 2.71 mL | 13.53 mL | 27.06 mL |
5 mM | 0.54 mL | 2.71 mL | 5.41 mL |
*The above data is based on the productmolecular weight 369.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Cat. No. | Product Name | Solubility(mg/mL) | ||
---|---|---|---|---|
Water | DMSO | Ethanol | ||
A10255 | ABT-737 | <1 mg/mL | 163 mg/mL | <1 mg/mL |
A10022 | ABT-263 (Navitoclax) | <1 mg/mL | 195 mg/mL | <1 mg/mL |
A10665 | Obatoclax mesylate (GX15-070) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
A10955 | TW-37 | <1 mg/mL | 115 mg/mL | 4 mg/mL |
A10984 | VX-765 | <1 mg/mL | 102 mg/mL | 102 mg/mL |
A11090 | PAC-1 | <1 mg/mL | 78 mg/mL | 16 mg/mL |
A10491 | JNJ 26854165 | <1 mg/mL | 66 mg/mL | 2 mg/mL |
A11931 | RITA (NSC 652287) | <1 mg/mL | 115 mg/mL | 4 mg/mL |
A10522 | Lenalidomide (CC-5013) | <1 mg/mL | 52 mg/mL | <1 mg/mL |
A10743 | Pomalidomide (CC-4047) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
A11163 | AT-406 | <1 mg/mL | 112 mg/mL | 112 mg/mL |
A11002 | YM155 | 89 mg/mL | 55 mg/mL | 6 mg/mL |
A10935 | Tipifarnib (Zarnestra) | <1 mg/mL | 83 mg/mL | <1 mg/mL |
A10657 | Nutlin-3 | <1 mg/mL | 116 mg/mL | 116 mg/mL |
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