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Tenovin-1

p53 activator

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Catalog No. A11943

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Tenovin-1 25mg A11943-25
€76.00
Tenovin-1 50mg A11943-50
€133.00
Tenovin-1 100mg A11943-100
€237.50
Tenovin-1 10mM * 1mL in DMSO A11943-10mM-D
€67.45

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation.

Tenovin-1

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Chemical Information

Catalog Num A11943
Actions Activator
M. Wt 369.5
Formula C20H23N3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 380315-80-0
Synonyms N/A
SMILES code CC(=O)NC1=CC=C(C=C1)NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C
Chemical Name N-?[[[4-?(acetylamino)phenyl]amino]thioxomethyl-?4-?(1,?1-?dimethylethyl)]-?benzamide

Biological Activity

Description
 Tenovin-1 is a small molecule activator of p53 transcriptional activity that protects against MDM2-mediated p53 degradation.
Targets
p53 Mdm2

Solubility

Solubility (25°C) * In vitro DMSO 74 mg/mL (200.28 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.06 mL 135.32 mL 270.64mL
0.5 mM 5.41 mL 27.06 mL 54.13 mL
1 mM 2.71 mL 13.53 mL 27.06 mL
5 mM 0.54 mL 2.71 mL 5.41 mL

*The above data is based on the productmolecular weight 369.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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