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Biological Activity
CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
| In vitro | DMSO | 35 mg/mL (93.86 mM) | |
| Water | 22 mg/mL (59 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.82 mL | 134.09 mL | 268.18 mL |
| 0.5 mM | 5.36 mL | 26.82 mL | 53.64 mL |
| 1 mM | 2.68 mL | 13.41 mL | 26.82 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
*The above data is based on the productmolecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16836 |
|---|---|
| Actions | Inhibitor, Activator |
| CAS No. | 1197397-89-9 |
| Formula | C21H24N2O2.HCl |
| M. Wt | 372.89 |
| Purity | >98% |
| Synonyms | CBL0137, CBL 0137, Curaxin 137, Curaxin137, Curaxin-137, CBLC137, CBLC 137, CBLC-137 |
| SMILES | CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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