CBL-0137

Catalog No.: A16836

p53 activator / NF-κB inhibitor

CBL-0137

CBL-0137 Chemical Structure

CAS NO. 1197397-89-9

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
50 mg
$980.00
100 mg
$1,600.00
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Biological Activity

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
In vitro DMSO 35 mg/mL (93.86 mM)
Water 22 mg/mL (59 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.82 mL 134.09 mL 268.18 mL
0.5 mM 5.36 mL 26.82 mL 53.64 mL
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16836
Actions Inhibitor, Activator
CAS No. 1197397-89-9
Formula C21H24N2O2.HCl
M. Wt 372.89
Purity >98%
Synonyms CBL0137, CBL 0137, Curaxin 137, Curaxin137, Curaxin-137, CBLC137, CBLC 137, CBLC-137
SMILES CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C.Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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