CBL-0137

Catalog No.: A16836

p53 activator / NF-κB inhibitor

CBL-0137

CBL-0137 Chemical Structure

CAS NO. 1197397-89-9

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
50 mg
$980.00
100 mg
$1,600.00
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Biological Activity

CBL0137(CBL-0137) activates p53 and inhibits NF-kB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.82 mL 134.09 mL 268.18 mL
0.5 mM 5.36 mL 26.82 mL 53.64 mL
1 mM 2.68 mL 13.41 mL 26.82 mL
5 mM 0.54 mL 2.68 mL 5.36 mL

*The above data is based on the productmolecular weight 372.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16836
Actions Inhibitor, Activator
M. Wt 372.89
Formula C21H24N2O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1197397-89-9
Synonyms CBL0137, CBL 0137, Curaxin 137, Curaxin137, Curaxin-137, CBLC137, CBLC 137, CBLC-137
SMILES CC(/N=C/CN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl

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