Catalog No.
Product Name
Application
Product Information
Citations
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Prostaglandin Lactone
PGF2α 1,9-lactone is a stable prostaglandin lactone that demonstrates resistance to hydrolysis by plasma esterases. This compound is critical in studies examining the pharmacological effects of prostaglandins and their roles in various biological processes. PGF2α 1,9-lactone is utilized in research focused on reproductive biology, cardiovascular function, and inflammation, providing valuable insights into prostaglandin signaling pathways. -
FP Receptor Agonist
Cloprostenol isopropyl ester is a potent FP receptor agonist, exhibiting a dissociation constant (Ki) of 28 nM. This compound serves as a prostaglandin F2α analog and is a valuable intermediate for synthesizing (+)-Cloprostenol. Its biological activity makes it suitable for research applications in reproductive biology and studies involving prostaglandin signaling pathways. -
Metabolite
Dinorprostaglandin E1 (dinor-PGE1) is a key metabolite of prostaglandin E1 and prostaglandin E. It primarily exerts its biological activity by inhibiting glycogenolysis stimulated by glucagon, epinephrine, and isoproterenol, particularly in hepatocytes. This compound is important for research applications focused on metabolic regulation and the signaling pathways influenced by prostaglandins. -
TXA2/PGH2 Receptor Antagonist
ONO 3708 is a selective antagonist of the TXA2/PGH2 receptor, effectively inhibiting the binding of U46619 to human platelets with an IC50 value of 38 nM. This compound is valuable for research into platelet activation and thrombus formation, making it applicable in studies focused on cardiovascular diseases and coagulation processes. Its specificity allows for detailed investigation of TXA2 signaling pathways and their implications in various physiological and pathological conditions. -
Thromboxane B2 Metabolite
2,3-Dinor thromboxane B1 is a key urinary metabolite of Thromboxane B2, functioning as a biomarker in thromboxane biosynthesis pathways. This compound is important for studying platelet activation and vascular physiology, as it is involved in various cardiovascular and inflammatory responses. Research applications include the investigation of thromboxane signaling and its implications in thromboembolic disorders. -
Prostaglandin Derivative
15(R)-Prostaglandin E2 is a prostaglandin derivative that modulates various physiological processes through its interaction with prostaglandin receptors. It exhibits significant biological activity including anti-inflammatory effects and the regulation of blood flow. This compound is utilized in research focused on inflammation, vascular biology, and the mechanisms underlying pain and fever responses. -
TXA2 Receptor Inhibitor
BM-531 is a dual-action thromboxane receptor (TXA2) inhibitor that also functions as a thromboxane synthase inhibitor. This compound demonstrates significant anti-aggregatory effects on human citrated platelet-rich plasma, effectively inhibiting arachidonic acid-induced aggregation with an ED100 of 0.125 μM and U-46619-induced aggregation with an ED50 of 0.482 μM. Additionally, BM-531 is shown to inhibit contraction in porcine uterine smooth muscle induced by high potassium levels, making it a valuable tool for research in thrombosis and uterine contractility studies. -
Prostaglandin Analog
Latanoprost ethyl amide is a modified prostaglandin analog that serves as a selective ocular hypotensive agent. By altering the C-1 carboxyl group to an N-ethyl amide, this compound may offer an alternative delivery mechanism for prostaglandin activity. Recent studies reveal that Latanoprost ethyl amide can be converted to its active free acid form in bovine and human corneal tissue, albeit at a slower rate compared to traditional prostaglandin esters. This unique pharmacokinetic profile may enhance its therapeutic potential in the treatment of intraocular pressure-related conditions. -
EP4 Antagonist
TP-16 is a selective antagonist of the EP4 receptor, demonstrating an IC50 value of 2.1 nM. This compound effectively inhibits EP4-mediated signaling pathways, making it a valuable tool for investigating the role of EP4 in various physiological and pathological processes. TP-16 is particularly relevant for research in inflammation, pain, and cancer biology, providing insights into therapeutic interventions targeting the prostaglandin receptor system. -
Prostacyclin Analog
OP-2507 is a prostacyclin analog that primarily targets prostacyclin receptors. It has been shown to elevate glucose levels in the brain of mice and mitigate energy metabolism disruptions under hypoxic conditions. Additionally, OP-2507 exerts protective effects on cyclic nucleotide levels in hypoxic brain tissue, specifically enhancing cyclic AMP while reducing cyclic GMP. This compound demonstrates potential in addressing brain hypoxia and associated edema. -
Cyclooxygenase Inhibitor
KC-764 is an orally active, reversible inhibitor of cyclooxygenase, preferentially targeting platelet cyclooxygenase. It effectively reduces platelet thromboxane A2 (TXA2) production and inhibits platelet aggregation, exhibiting IC50 values of 0.23 μM and 26 nM, respectively. This compound is valuable for research focused on antiplatelet therapy and the prevention of recurrence in ischemic stroke. -
TXA2 Inhibitor
(E/Z)-Ozagrel sodium is a selective thromboxane A2 (TXA2) synthase inhibitor, exhibiting an IC50 value of 11 nM. By inhibiting TXA2 production, it promotes vasodilation and exhibits anti-platelet aggregation and anti-inflammatory effects through increased prostacyclin (PGI2) levels. This reagent is valuable for research into ischemic stroke, asthma, and thromboembolic diseases. -
FP/TP Receptor Inhibitor
CAY10535 is an inhibitor of the FP and TP receptors, targeting key pathways involved in cardiovascular function. This compound demonstrates potential for elucidating the role of these receptors in cardiovascular disease pathology. It serves as a valuable tool for researchers investigating therapeutic interventions aimed at modulating prostanoid signaling in cardiovascular conditions. -
Carbacyclin Derivative
Carbaprostacyclin methyl ester is a methylated derivative of Carbacyclin, primarily targeting prostacyclin receptors. This compound exhibits potent vasodilatory effects and anti-platelet aggregation properties. It is utilized in cardiovascular research to investigate the modulation of blood flow and platelet function, making it essential for studies related to thrombotic disorders and vascular health. -
Platelet Aggregation Inhibitor
MED 27 is a potent inhibitor of thromboxane synthase and thromboxane A2 receptors. It effectively inhibits rat platelet aggregation at significantly lower doses compared to acetylsalicylic acid. This compound is valuable for research applications focused on cardiovascular disorders and the mechanisms of platelet function. -
Prostaglandin Receptor
9-deoxy-9-methylene Prostaglandin E2 is a stable isosteric analog of Prostaglandin E2 (PGE2) targeting prostaglandin receptors. It exhibits similar biological activity to PGE2 while demonstrating a reduced side effect profile. Research indicates that 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in lowering blood pressure in rats and effectively stimulates colonic activity in gerbils as well as uterine contractions in primates, making it valuable for studies on cardiovascular and reproductive physiology. -
FP Antagonist
Prostaglandin F2α dimethyl amine is a derivative of Prostaglandin F2α that serves as an antagonist for the Prostaglandin F receptor (FP). This compound effectively inhibits the cardiovascular responses triggered by orexin and arachidonic acid, making it a valuable tool in cardiovascular research. Its ability to modulate FP activity positions it as a significant reagent for studies investigating prostaglandin-mediated signaling pathways and related physiological effects. -
PGD2 Metabolite
Tetranor-PGDM is a key urinary metabolite derived from prostaglandin D2 (PGD2) biosynthesis. It serves as an essential biomarker for studying PGD2 metabolism and its associated biological pathways. This compound is widely utilized in research applications aimed at understanding inflammatory responses, sleep regulation, and allergic reactions linked to PGD2 levels. -
Prostaglandin Receptor Inhibitor
Iso-Samixogrel is a potent prostaglandin receptor inhibitor, functioning as both a thromboxane A2 receptor blocker and a thromboxane synthetase inhibitor. This compound demonstrates significant antithrombotic activity by effectively preventing recurrent arterial thrombus formation and inhibiting collagen-induced platelet aggregation in ex vivo studies. Additionally, Iso-Samixogrel prolongs sublingual bleeding time, indicating its potential utility in the management of thrombotic disorders. -
Prostacyclin Receptor Agonist
AFP-07 free acid is a potent and selective agonist of the prostacyclin IP receptor, exhibiting a Ki value of 0.561 nM. This compound is used in research applications related to cardiovascular biology and inflammation, where it may help elucidate the role of prostacyclin signaling in various pathophysiological processes. Its specificity makes AFP-07 free acid a valuable tool for studying the therapeutic potential of prostacyclin modulation in disease models. -
PGF2 Analog
20-ethyl Prostaglandin F2α is a synthetic analog of Prostaglandin F2α, functioning as a potent modulator of the prostaglandin pathway. It exhibits key biological activities, including contraction of smooth muscle and regulation of vascular tone. This compound is widely used in research applications related to reproductive biology, cardiovascular studies, and inflammation. -
EP3 Receptor Agonist
MB-28767 is an EP3 receptor agonist that specifically activates the prostaglandin E receptor subtype 3. This compound exhibits significant biological activity in modulating inflammatory responses and has potential applications in pain management and neuroprotection research. Its ability to influence various physiological processes makes it a valuable tool in studying EP3 receptor-related pathways in diverse biological systems. -
Prostaglandin Receptor
15(S)-15-methyl Prostaglandin D2 is a synthetic analog of PGD2 that targets prostaglandin receptors, offering enhanced metabolic stability. This compound is known to induce vasoconstriction and elevate systemic blood pressure while exhibiting significantly reduced inhibitory effects on ADP-induced platelet aggregation. Additionally, it demonstrates potent antifertility activity in hamsters, being 200-fold more effective than PGD2. It serves as a valuable tool for research into cardiovascular physiology and reproductive biology. -
Dinoprost Analog
PGF2α analogue-1 is a dinoprost analog featuring an acetylenic fluorobenzene substituent within the lower side chain. This compound is designed to selectively interact with prostaglandin receptors, exhibiting significant biological activity related to smooth muscle contraction and modulation of vascular tone. It serves as a valuable tool in research applications focused on reproductive biology, cardiovascular studies, and the exploration of inflammation pathways. -
TXA2 Inhibitor
Isbogrel is a selective inhibitor of thromboxane A2 (TXA2) synthase, demonstrating potent activity in reducing TXA2 generation in the bloodstream. With an ID50 value of 0.04 mg/kg, Isbogrel exhibits effective oral bioavailability. This compound is primarily utilized in research focused on cardiovascular diseases and thrombotic disorders, contributing to the understanding of TXA2's role in platelet aggregation and vascular functions. -
Antiprogestogen Drug
Gemeprost is an analogue of Prostaglandin E1 that functions as a potent antiprogestogen. This compound is primarily used in research related to second trimester abortion, influencing reproductive tissue by modulating progesterone activity. Its biological activity makes it a valuable tool for studies investigating reproductive health and associated therapies. -
PGI2 Agonist
FR181157 is an orally active prostacyclin (PGI2) agonist that exhibits favorable pharmacokinetic properties. It plays a crucial role in promoting vasodilation and inhibiting platelet aggregation, making it valuable for research in cardiovascular disorders and pulmonary hypertension. Its potent biological activity provides a useful tool for understanding the therapeutic potential of PGI2 modulation in various disease models. -
Derivative of PGA2
Prostaglandin A2 methyl ester is a methylated derivative of prostaglandin A2, known for its role in various physiological processes. This compound is used in research to study the effects of prostaglandins in inflammation, pain modulation, and reproductive functions. Its ability to mimic the biological activity of PGA2 makes it a valuable tool for exploring signaling pathways and potential therapeutic targets in related studies. -
C-8 Diastereomer of BW 245C
(8-epi)-BW 245C is the C-8 diastereomer of BW 245C, functioning as a selective agonist for the PGD2 receptor. This compound exhibits high affinity for its target, making it a valuable tool in studying PGD2-mediated signaling pathways. Its utility extends to research in areas such as inflammation, allergy responses, and sleep regulation, providing insights into the role of PGD2 in various biological processes. -
EP2 Receptor Antagonist
TG6-129 is a selective antagonist of the EP2 receptor, primarily involved in modulating inflammatory responses. This compound has been shown to reduce the expression of inflammatory factors induced by butaprost in P388D1 macrophages. TG6-129 is valuable for researchers studying inflammation and related signaling pathways. -
Prostaglandin
Prostaglandin F2α 1,11-lactone primarily targets prostaglandin receptors and exhibits significant ocular absorption. This compound demonstrates metabolic stability at the corneal surface and conjunctiva, making it particularly valuable in ophthalmic research. Prostaglandin F2α 1,11-lactone is commonly employed in studies related to glaucoma treatment, providing insights into aqueous humor dynamics and intraocular pressure regulation. -
Endogenous Hormone
Prostaglandin E2 serinol amide is a non-hydrolyzable analogue of the endogenous hormone Prostaglandin E2, targeting the inhibition of the hydrolysis of [3H]2-oleoylglycerol. This compound does not convert to PGE2 and, therefore, lacks the capacity to inhibit leukotriene B4 biosynthesis, superoxide production, cellular migration, and the release of antimicrobial peptides. It serves as a useful tool for investigating the roles of prostaglandins in various biological processes. -
FP-receptor Agonist
AL-12180 is a potent and selective FP-receptor agonist, exhibiting a Ki of 143 nM. This compound effectively stimulates the mobilization of intracellular Ca2+ in human trabecular meshwork (h-TM) and cardiac muscle (h-CM) cells, demonstrating EC50 values of 111 nM and 11 nM, respectively. AL-12180 is valuable for research applications investigating FP-receptor signaling pathways and related physiological processes. -
PGF2α Analogue
Froxiprost is a PGF2α analogue that primarily targets the prostaglandin receptor pathway. It has been shown to stimulate thymidine uptake, promote the accumulation of 1,2-diacylglycerol (1,2-DAG), and facilitate the formation of phosphorylcholine in osteoblast-like MC3T3-E1 cells. This compound is valuable for research into bone metabolism, cell signaling, and the role of prostaglandins in osteogenic differentiation. -
Thromboxane Synthase Inhibitor
LG 82-4-00 is a selective thromboxane synthase inhibitor with an IC50 of 1.1 μM. This compound effectively inhibits collagen-induced formation of TXB2 and subsequently reduces platelet aggregation in plasma. LG 82-4-00 serves as a valuable tool in research focused on thrombotic disorders, contributing to the understanding of thromboxane's role in vascular biology and pathology. -
Platelet Inhibitor
Prostaglandin D3 (PGD3) is a natural prostaglandin that functions as an inhibitor of platelet aggregation. Its primary biological activity involves modulation of autonomic neurotransmission. PGD3 is utilized in research to study cardiovascular diseases and platelet activity, making it a valuable reagent for investigations into thrombosis and related conditions. -
PGF2α Analog
Prostaglandin F2α alcohol is an analog of Prostaglandin F2α (PGF2α), functioning as a potent agonist of the FP receptor. It plays a crucial role in various biological processes, including smooth muscle contraction and regulation of reproductive functions. This compound is widely utilized in research applications related to reproductive biology, inflammation, and cardiovascular studies. -
IP Receptor Agonist
19(S)-HETE is an arachidonic acid metabolite synthesized by cytochrome P450 enzymes and serves as a full orthosteric agonist of the prostacyclin (IP) receptor, exhibiting an EC50 value of 567 nM. Its biological activity includes inhibition of platelet activation and promotion of vascular relaxation. This compound is utilized in research exploring cardiovascular functions and the modulation of platelet activity. -
PGF2α Analog
17-Phenyl trinor prostaglandin F2α diethyl amide is a potent PGF2α analog known for its hypotensive effects. This compound selectively targets the prostaglandin receptor pathways, making it valuable in cardiovascular research. Its biological activity supports various studies focused on blood pressure regulation and related therapeutic applications. -
Coronary Vasodilator
Teopranitol is a coronary vasodilator that primarily targets venous dilation. This compound is essential for investigating acute myocardial ischemia, providing valuable insights into cardiac function and potential therapeutic interventions. Its selective action on venous blood vessels makes it a useful tool in cardiovascular research. -
DP2 Receptor Antagonist
AM-461 is a potent antagonist of the DP2 receptor, a key component involved in prostaglandin signaling. This compound exhibits significant potential in the study of inflammation and immunology, making it particularly relevant for research on conditions such as asthma. Its mechanism of action allows for a deeper exploration of the pathways and effects related to immune responses and inflammatory processes. -
Prostacyclin Stable Mimetic Agent
RS 93427-007 is an orally active prostacyclin stable mimetic agent that primarily targets the prostacyclin receptor. This compound exhibits significant biological activity in modulating vascular tone and inhibiting platelet aggregation, making it valuable for research in cardiovascular diseases, including atherosclerosis. RS 93427-007 serves as a critical tool for exploring therapeutic strategies aimed at vascular-related pathologies. -
TP Receptor Antagonist
TP Receptor Antagonist-2 is a selective thromboxane A2 receptor (TP receptor) antagonist, exhibiting IC50 values of 5.64 μM and 5.27 μM for the TPα and TPβ isoforms, respectively. This compound effectively inhibits platelet aggregation, making it a valuable tool for research into cardiovascular conditions and thrombotic disorders. Its application in studying TP receptor signaling pathways enhances understanding of related physiological and pathological processes. -
NSAID
Alclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) that functions as a prostaglandin H2 synthase inhibitor. It exhibits significant anti-inflammatory and analgesic properties, making it valuable in the study of rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. This compound is instrumental for researchers investigating the underlying mechanisms and potential therapeutic strategies for inflammatory conditions. -
Prostaglandin D2 Receptor Agonist
5-trans Prostaglandin D2 is a selective agonist for the prostaglandin D2 receptor. It plays a significant role in modulating various physiological processes, including inflammation and immune responses. This compound is valuable for research applications related to allergic reactions, asthma, and neurodegenerative diseases, making it an important tool for studying prostaglandin signaling pathways. -
EP3 Receptor Antagonist
EP3 Antagonist 7 is a selective antagonist of the EP3 receptor, playing a critical role in modulating inflammatory responses. This compound exhibits significant biological activity in the context of pain, pruritus, dysuria, and various stress-related disorders. Its application in research provides insight into the physiological mechanisms and therapeutic targets associated with EP3 receptor signaling. -
Prostanoid Receptor Ligand
11-epi-PGE1 (11β-Prostaglandin E1) is a prostanoid receptor ligand that serves as a less potent isomer of Prostaglandin E1. This compound is utilized in research to investigate the modulation of prostanoid signaling pathways and their associated biological effects. Its unique properties may facilitate studies in inflammation, vascular biology, and other physiological processes where prostaglandins play a crucial role. -
TXA2 Receptor Antagonist
Z-335 sodium is an orally active thromboxane A2 (TXA2) receptor antagonist. It demonstrates potent inhibition with IC50 values of 29.9 nM and 32.5 nM in human and guinea pig platelets, respectively. This compound is useful in studying the physiological and pathological roles of TXA2 in various conditions, including cardiovascular diseases and platelet aggregation. -
EP3 receptor Antagonist
EP3 antagonist 5 is a selective antagonist of the EP3 receptor, exhibiting an IC50 value of 67 nM. This compound effectively inhibits EP3 receptor-mediated signaling, making it a valuable tool for studying the role of prostaglandin E receptors in various biological processes. Its application spans research into inflammatory responses, pain mechanisms, and potential therapeutic strategies for related diseases. -
TPα/β Antagonist
TPα/β antagonist-1 is a selective antagonist of the thromboxane A2 receptors TPα and TPβ, exhibiting IC50 values of 1.52 nM and 0.79 nM, respectively. This compound effectively inhibits U-46619-induced intracellular calcium mobilization and reduces platelet aggregation. TPα/β antagonist-1 is valuable for investigating mechanisms underlying cardiovascular diseases and evaluating potential therapeutic strategies.
