TP receptor antagonist-2

Catalog No.: A63278
TP Receptor Antagonist
TP Receptor Antagonist-2 is a selective thromboxane A2 receptor (TP receptor) antagonist, exhibiting IC50 values of 5.64 μM and 5.27 μM for the TPα and TPβ isoforms, respectively. This compound effectively inhibits platelet aggregation, making it a valuable tool for research into cardiovascular conditions and thrombotic disorders. Its application in studying TP receptor signaling pathways enhances understanding of related physiological and pathological processes.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTP Receptor Antagonist-2 is a selective thromboxane A2 receptor (TP receptor) antagonist, exhibiting IC50 values of 5.64 μM and 5.27 μM for the TPα and TPβ isoforms, respectively. This compound effectively inhibits platelet aggregation, making it a valuable tool for research into cardiovascular conditions and thrombotic disorders. Its application in studying TP receptor signaling pathways enhances understanding of related physiological and pathological processes.
Product Information
Catalog NumA63278
FormulaC18H18ClN3O4S
Molecular Weight407.87
CAS Number1448452-22-9
SMILESCC(C)(NC(NS(=O)(C1=C(OC2=CC=C(Cl)C=C2)C=CC(C#N)=C1)=O)=O)C
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