Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Lofexidine-d4 is a deuterium-labeled derivative of Lofexidine (hydrochloride), a selective α2-adrenergic receptor agonist. This compound is primarily employed in research related to opioid withdrawal by mimicking the activity of Lofexidine in biological assays. The stable isotope labeling enables precise tracking in pharmacokinetic studies and helps in elucidating the pharmacological properties of opioid withdrawal treatments. -
β3-adrenergic Receptor Agonist
N-5984 hydrochloride is a potent and selective agonist of the β3-adrenergic receptor. This compound exhibits significant biological activity in promoting lipolysis and thermogenesis, making it a valuable tool for research on obesity and diabetes mellitus. Its specificity for the β3-adrenergic receptor allows for targeted investigations into metabolic regulation and potential therapeutic applications in metabolic disorders. -
β-Adrenergic Receptor Antagonist
Falintolol is a selective β-adrenergic receptor antagonist that exhibits potential therapeutic effects in ocular conditions, particularly in the management of glaucoma. By inhibiting β-adrenergic receptor activity, it effectively reduces intraocular pressure, thereby facilitating research into novel treatment strategies for this prevalent eye disease. This compound is valuable for exploring the role of adrenergic signaling in ocular health and disease. -
β-Adrenergic Receptor Inhibitor
Bufetolol is a selective β-adrenergic receptor inhibitor that modulates cardiac activity by decreasing the maximum rate of depolarization during action potentials. Its antiarrhythmic properties make it a valuable tool for research into the mechanisms of cardiac rhythm disorders. Bufetolol is utilized in studies aimed at exploring therapeutic strategies for arrhythmias and related cardiovascular conditions. -
α2 Adrenergic Receptor Antagonist
Org 6906 is an α2 Adrenergic Receptor antagonist that promotes monoaminergic neurotransmission by inhibiting the reuptake of noradrenaline, dopamine, and serotonin. With a pKi value of 6.3, Org 6906 demonstrates significant antidepressant activity, making it a valuable tool for research into neurological disorders. This compound's mechanisms provide insight into the modulation of neurotransmitter systems and their implications for mental health therapies. -
Adrenergic Receptor
Bremazocine is a potent agonist of the kappa opioid receptor, demonstrating significant analgesic activity. It exerts its effects by enhancing the release of endogenous norepinephrine, leading to peripheral analgesia. Additionally, Bremazocine interacts with adenosine receptors, further contributing to its analgesic properties. Its peripheral analgesic effects are dose-dependent and may be influenced by nonselective α(2) adrenergic receptor antagonists, indicating a mechanism involving norepinephrine pathways. This compound is suitable for research applications focused on pain modulation and neuropharmacology. -
β2-adrenergic Receptor Agonist
Carbuterol hydrochloride is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle, demonstrating significant bronchodilatory and anti-allergic properties. This compound effectively inhibits the immunologically induced release of histamine and slow-reacting substance of anaphylaxis, thereby mitigating allergic responses. Additionally, it exhibits mild β1-mediated cardiac stimulation and is pertinent for research involving respiratory and immune-related conditions, such as asthma and allergic disorders. -
Adrenergic Receptor Antagonist
Pargolol is a selective β-adrenergic receptor antagonist. It effectively inhibits β-receptor-mediated signaling pathways, thereby regulating cardiovascular responses. Pargolol is utilized in research focused on cardiovascular pharmacology, hypertension, and the role of adrenergic signaling in various physiological processes. Its mechanism is valuable for studying the therapeutic effects of β-blockade in preclinical models. -
Stable Isotope
(rac)-Dobutamine-d4 hydrochloride is a stable isotope-labeled form of the synthetic catecholamine Dobutamine hydrochloride, which primarily targets β1-adrenergic receptors (β1-AR) with lower affinity for α1-adrenergic (α1-AR) and β2-adrenergic receptors (β2-AR). This compound is known for its ability to enhance cardiac output and ameliorate conditions of hypoperfusion. It serves as a valuable tool in pharmacological research, particularly in studies focused on cardiovascular function and receptor activity. -
Adrenergic Receptor Agonist
Methylhexanamine hydrochloride is an adrenergic receptor agonist that functions as a potent vasoconstrictor. This compound primarily acts to alleviate nasal congestion by inducing vasoconstriction in the nasal mucosa when administered via inhalation. Its properties make it a valuable tool for research into respiratory therapies and the modulation of vascular responses. -
Adrenergic Receptor Agonist
A-61603 (free base) is a potent agonist of adrenergic receptors, specifically targeting α1 and α2 subtypes. This compound significantly reduces carotid artery conductance in anesthetized pig models, demonstrating a pEC50 of 7.25. A-61603 (free base) serves as an effective tool for investigating adrenergic signaling pathways and their physiological implications in cardiovascular research. -
β2-adrenergic Receptor Agonist
Clorprenaline-d7 is a deuterium-labeled derivative of Clorprenaline, which functions as a selective agonist for the β2-adrenergic receptor. This compound facilitates bronchial expansion and is significant in the investigation of asthma and respiratory disorders. It is valuable for research applications focusing on pulmonary function, receptor pharmacology, and the development of bronchodilator therapies. -
Indacaterol S-enantiomer
(S)-Indacaterol is the S-enantiomer of Indacaterol, functioning as an ultra-long-acting β2 adrenergic receptor (ADRB2) agonist. This compound exhibits potent bronchodilatory activity, making it a valuable resource in respiratory research, particularly for conditions such as asthma and chronic obstructive pulmonary disease (COPD). Its prolonged duration of action supports studies aimed at understanding and developing new therapeutic strategies targeting β2 adrenergic pathways. -
α2-Adrenergic Receptor Antagonist
Fipamezole hydrochloride is a potent α2-adrenergic receptor antagonist, exhibiting Ki values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C receptors, respectively. This compound functions as an anti-dyskinetic agent, making it valuable for research into Parkinson's disease. Its selective action on α2-adrenergic receptors offers insights into the modulation of dopaminergic activity and potential therapeutic strategies for movement disorders. -
Stable Isotope
Phentolamine-d4 hydrochloride is a deuterated form of Phentolamine hydrochloride, a reversible and non-selective inhibitor of α1 and α2 adrenergic receptors. This compound is utilized primarily for its vasodilatory effects, which reduce peripheral vascular resistance. Phentolamine-d4 hydrochloride is valuable in research applications related to pheochromocytoma-induced hypertension, heart failure, and erectile dysfunction, providing insights into adrenergic receptor modulation in these conditions. -
Stable Isotope
Mabuterol-d9 hydrochloride is a deuterium-labeled form of Mabuterol hydrochloride, targeting the beta-2 adrenergic receptor (ADRB2) as a selective agonist. This compound exhibits the ability to inhibit cellular proliferation and reduce PDGF-BB-induced increases in intracellular calcium levels. Additionally, Mabuterol hydrochloride downregulates the expression of key proteins such as Drp-1, cyclin D1, and PCNA, while promoting the expression of Mfn-2. This reagent is valuable for research involving cellular signaling, proliferation, and metabolic regulation. -
Adrenoreceptor Agonist
Colterol is a selective agonist for adrenergic receptors, demonstrating strong affinity for β1-adrenoreceptors (IC50 = 645 nM) and β2-adrenoreceptors (IC50 = 147 nM). This compound exhibits significant bronchodilator activity, making it useful in respiratory research and the study of cardiovascular effects. Its affinity profile also supports applications in pharmacological studies aimed at understanding adrenergic signaling pathways. -
Adrenergic Receptor
Tolamolol is a selective beta-adrenergic antagonist primarily targeting the beta-adrenergic receptor, known for its efficacy in reducing exercise-induced ST-segment depression. It demonstrates significant activity in alleviating angina, offering greater cardiac selectivity compared to other non-selective beta-blockers. Tolamolol effectively decreases the frequency of angina attacks and the reliance on glyceryl trinitrate, while also contributing to blood pressure reduction and enhancing exercise capacity prior to angina onset. Additionally, Tolamolol provides beneficial effects in the suppression of arrhythmias. -
alpha 2 Antagonist
R 47 243 is a potent racemic antagonist of the alpha-2 adrenergic receptor. This compound demonstrates significant activity that may be leveraged in the study and exploration of Parkinson's disease mechanisms and treatment strategies. Its ability to modulate α2 adrenergic signaling makes it a valuable tool for researchers investigating neurodegenerative conditions. -
Adrenergic Receptor Antagonist
Medroxalol hydrochloride is an orally active adrenergic receptor antagonist that inhibits both α- and β-adrenergic receptors. This compound demonstrates significant antihypertensive and vasodilating properties, making it valuable for studies related to cardiovascular pharmacology. Its ability to modulate adrenergic signaling pathways is useful in researching conditions such as hypertension and heart disease. -
Metabolites
5-Hydroxy propranolol is a key metabolite of Propranolol, primarily targeting β-adrenergic receptors. This compound plays an important role in studying the pharmacological effects associated with β-blockade, providing insights into cardiovascular function and neuropharmacology. Its application in biochemical research aids in understanding the metabolism and therapeutic implications of propranolol and its derivatives. -
Adrenergic Receptor Agonist
Dopexamine is a selective β2 adrenergic receptor agonist that enhances cardiac output and improves myocardial contractility. It is primarily utilized in research to study cardiovascular function and inotropic effects. This compound is often employed in investigations related to heart failure and hemodynamic support. -
Adrenergic Receptor Ligand
AR Ligand-50 is an adrenergic receptor ligand with a pKi value of 7.14 for the human α2-adrenergic receptor, assessed in CHO cells. This compound demonstrates significant biological activity that can be utilized in the investigation of neurological disorders. Its potential therapeutic implications make it a valuable tool for research focused on adrenergic signaling pathways and related disease mechanisms. -
Adrenergic Receptor Agonist
KUL-7211 is a selective β-adrenoceptor agonist that activates β-adrenergic receptors, facilitating various physiological responses. This compound is primarily utilized in research focused on cardiovascular function, neuropharmacology, and the modulation of metabolic processes. Its ability to selectively engage β-adrenoceptors makes KUL-7211 valuable for studying the role of adrenergic signaling in health and disease. -
Stable Isotope
Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics. -
Stable Isotope
Ractopamine-d3 (hydrochloride) is a deuterated form of the potent β-adrenergic receptor (βAR) agonist, Ractopamine hydrochloride. With a Kd value of approximately 25 nM for pig β1AR and β2AR, this compound is known to promote muscle mass development, limit fat deposition, reduce feed consumption, and enhance protein synthesis in swine. It serves as a valuable tool in research focused on improving production efficiency and increasing lean tissue growth in agricultural settings. -
β3-AR Antagonist
L-748328 is a potent and selective antagonist of the human β3-adrenergic receptor (β3-AR), displaying a Ki value of 3.7 nM in assays with human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. This compound effectively inhibits the lipolytic response triggered by the β3-AR agonist L-742791 in isolated non-human primate adipocytes. L-748328 is valuable for research into metabolic regulation and adipocyte function, particularly in studies examining β3-AR signaling pathways and their implications in obesity and metabolic disorders. -
Stable Isotope
(rac)-Nebivolol-d4 is a stable isotope-labeled form of the racemic compound Nebivolol, which selectively targets the β1-adrenergic receptor with an IC50 of 0.8 nM. This reagent is valuable for pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Nebivolol in biological systems. Its stable isotope labeling facilitates investigations into drug interactions and receptor dynamics, offering insights into cardiovascular pharmacology. -
beta-3 Adrenoreceptor Agonist
β3-AR agonist 3 is a potent agonist of the beta-3 adrenergic receptor, known for its role in mediating metabolic processes. This compound exhibits key biological activity in the modulation of lipolysis and thermogenesis, making it relevant for studies related to adipose tissue regulation and metabolic disorders. β3-AR agonist 3 can also be utilized in research focused on prostatitis and other urogenital conditions, contributing valuable insights into therapeutic applications. -
Adrenergic Receptor Agonist
Cicloprolol hydrochloride is a partial agonist of the β1-adrenergic receptor. It exhibits cardiovascular effects through the modulation of heart rate and contractility, making it a valuable tool in studies related to hypertension and heart failure. This compound is useful for investigating adrenergic receptor signaling and the physiological responses associated with β1-adrenergic activation. -
Adrenergic Receptor Agonist
TD-5471 hydrochloride is a potent and selective full agonist of the human β2-adrenoceptor. This compound is instrumental in studying adrenergic signaling pathways and has implications in respiratory research, particularly in the context of asthma and chronic obstructive pulmonary disease (COPD). Additionally, TD-5471’s selective activity makes it a valuable tool for exploring β2-adrenoceptor-mediated physiological responses in various biological systems. -
Adrenergic Receptor Antagonist
Pamatolol is a cardioselective beta-adrenoceptor antagonist that exhibits no sympathomimetic activity. This compound selectively inhibits beta-adrenergic receptors, leading to potential applications in the treatment of cardiovascular diseases. Pamatolol is utilized in research related to heart function regulation and the exploration of adrenergic signaling pathways. -
Adrenergic Receptor Inhibitor
Teoprolol is a selective β-adrenergic receptor inhibitor that effectively modulates adrenergic signaling pathways. It exhibits key biological activities including the reduction of heart rate and myocardial contractility, making it valuable for cardiovascular research. Teoprolol is widely used in studies investigating hypertension, anxiety, and heart failure, contributing to our understanding of adrenergic receptor function and pharmacological interventions. -
α1/β1-Adrenergic Receptor Inhibitor
Amosulalol hydrochloride functions as a dual inhibitor of α1 and β1-adrenergic receptors, demonstrating pronounced antihypertensive effects. By inhibiting α1-adrenergic receptors, it effectively lowers blood pressure, while β1-adrenergic receptor inhibition reduces reflexive increases in heart rate and plasma renin activity. This compound is particularly useful in studies involving spontaneously hypertensive rats, providing valuable insights into cardiovascular mechanisms and potential therapeutic interventions in hypertension. -
α2-Adrenergic Receptor Antagonist
Delequamine is a selective α2-adrenergic receptor antagonist with a pKi of 9.5 for α2-adrenoceptors in the rat cortex. It exhibits over 1000-fold selectivity against 5-HT1A receptors and α1-adrenoceptors. This compound is valuable for researching erectile dysfunction and exploring therapeutic options targeting adrenergic signaling pathways. -
ADRA2A Antagonist
Yohimbic acid ethyl ester is a selective antagonist of the alpha-2 adrenergic receptor subtype ADRA2A, exhibiting an IC50 of 31 nM. This compound is significant for studies investigating the modulation of adrenergic signaling pathways and has potential applications in researching cardiovascular function and neuropharmacology. Its specificity for ADRA2A makes it a valuable tool for exploring therapeutic strategies targeting adrenergic receptor-related disorders. -
α-adrenergic Receptor Agonist
Tuaminoheptane sulfate is an α-adrenergic receptor agonist that acts primarily by inhibiting norepinephrine reuptake and promoting its release. This compound exhibits pronounced decongestant and irritant effects, making it a valuable tool in the study of nasal pathologies. Its applications extend to research focused on nasal congestion and related disorders. -
Stable Isotope
(Rac)-Nebivolol-d4 hydrochloride is a stable isotope-labeled analog of racemic Nebivolol, which serves as a selective β1-adrenergic receptor inhibitor with an IC50 of 0.8 nM. This reagent is primarily utilized in pharmacokinetic studies and metabolic profiling, offering insights into drug metabolism and receptor interactions in various biological systems. Its application in research facilitates a deeper understanding of adrenergic signaling pathways and cardiovascular pharmacotherapy. -
β3 Adrenergic Receptor Agonist
L-770644 is a potent and selective agonist of the human β3 adrenergic receptor, with an EC50 of 13 nM, demonstrating oral bioactivity. This compound is primarily utilized in research exploring metabolic disorders, obesity, and diabetes, where modulation of β3 receptor activity may contribute to therapeutic strategies. Its specificity for the β3 receptor makes it a valuable tool for studying adrenergic signaling pathways and their physiological effects. -
Vasoconstrictor
Cafaminol, also known as Methylcoffanolamine, is a potent vasoconstrictor that selectively targets alpha-1 adrenergic receptors, leading to constriction of blood vessels. This xanthine derivative demonstrates significant activity in decongestion and offers potential applications in antitumor research. Its ability to modulate vascular response makes Cafaminol a valuable tool in studies related to vascular biology and therapeutic interventions. -
β-blocker
(S)-Alprenolol hydrochloride is a potent nonselective β-blocker that primarily targets β-adrenergic receptors. It exhibits significant antagonistic activity, which is useful in research involving cardiovascular pharmacology and the modulation of sympathetic nervous system responses. Applications of (S)-Alprenolol hydrochloride include studying hypertension, heart disease, and various conditions related to adrenergic signaling. -
Adrenergic Receptor Agonist
Adrenergic a2C receptor agonist-1 is a selective agonist of the adrenergic receptor a2C subtype. This compound modulates neurotransmitter release, contributing to its role in cardiovascular regulation and central nervous system activity. It is valuable for research applications focusing on adrenergic signaling pathways, neuropharmacology, and the investigation of disorders such as hypertension and anxiety. -
Calcium Entry-Blocking
YM-430 is a calcium entry-blocking and beta-adrenoceptor-blocking agent. It effectively inhibits Amifampridine-induced rhythmic contractions with an IC50 value of 59.2 nM and blocks arginine vasopressin-induced ST-segment depression with an IC50 of 36.6 mg/kg. This compound is valuable for research into angina pectoris and related cardiovascular conditions. -
Formoterol Metabolite
Formoterol O-β-D-glucuronide is a key metabolite of the long-acting β2-adrenoceptor agonist Formoterol. This compound serves as an important marker for studying the pharmacokinetics and metabolic pathways associated with β2-adrenergic receptor activation. Its examination can aid in understanding therapeutic applications in respiratory conditions and the overall pharmacological effects of Formoterol. -
Stable Isotope
Tamsulosin-d4 is a deuterium-labeled analog of Tamsulosin, a selective antagonist of the α1-adrenergic receptor. This compound is primarily utilized in the study of benign prostatic hyperplasia and offers insights into its pharmacological effects. Additionally, Tamsulosin has been shown to mitigate abdominal aortic aneurysm growth in preclinical models, making it a valuable reagent for cardiovascular research. -
Adrenergic Receptor Agonist
Isoxsuprine is a beta-adrenergic receptor agonist with binding affinities of 13.65 µM and 3.48 µM for myometrial and placental beta-adrenergic receptors, respectively. Additionally, isoxsuprine hydrochloride functions as an NMDA receptor antagonist. This compound is primarily utilized in research exploring its role in cardiovascular functions and its potential therapeutic applications in obstetrics. -
beta-Adrenergic Receptor Blocker
Brefonalol is a selective beta-adrenergic receptor blocker that plays a crucial role in modulating cardiovascular functions. It has demonstrated efficacy in the study of hypertension, arrhythmias, and angina pectoris, making it a valuable tool for research into cardiovascular diseases. Researchers can utilize Brefonalol to explore mechanisms of beta-receptor signaling and potential therapeutic interventions in heart-related disorders. -
AR Inhibitor
Amidephrine hydrochloride is an adrenergic receptor (AR) agonist that functions primarily by stimulating adrenergic signaling pathways. It demonstrates key biological activities relevant to neurological research, making it a valuable reagent for studying various neurological diseases and disorders. Its effects on AR modulation can facilitate investigations into therapeutic interventions and pharmaceutical development in the field of neuroscience. -
Adrenergic Receptor Antagonist
SU-4029 dihydrochloride is an adrenergic receptor antagonist that selectively interacts with alpha receptors. It effectively inhibits the action of norepinephrine, exhibiting a unique mechanism of action by differentiating between reversible and irreversible adrenergic blockers. Biological responses to SU-4029 include a spectrum of effects on pressor phenylalkylamines, indicating its potential utility in elucidating receptor interactions and mechanisms in cardiovascular research. The compound serves as a valuable tool for studying adrenergic signaling pathways and developing therapeutic strategies targeting alpha-adrenergic receptors. -
Neuroleptic Agent
(±)-Butaclamol hydrochloride is a neuroleptic agent that acts as an antagonist for adrenergic and dopamine receptors. It effectively antagonizes stereotyped behaviors and emesis induced by amphetamine and apomorphine, as well as inhibiting discriminative avoidance behavior. Additionally, it induces catalepsy in rat models, making it a valuable tool for research in behavioral pharmacology and neuropharmacology.
