Catalog No.
Product Name
Application
Product Information
Citations
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sGC stimulator
Riociguat (BAY 63-2521; BAY 632521) is a stimulator of soluble guanylate cyclase (sGC). -
sGC activator
YC-1 is a direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide. -
guanylate cyclase activator
(4-Acetamidocyclohexyl) nitrate (BM121307) is a guanylate cyclase activator that was in phase I development for the treatment of ischaemic heart disorders. The research has been discontinued. -
guanylate cyclase (sGC) stimulator
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay. -
Guanylate cyclase C agonist
Linaclotide is a peptide agonist of the guanylate cyclase 2C. -
sGC activator?€?
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator. -
guanylate cyclase stimulator
Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM. -
soluble guanylate cyclase stimulator
Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists. -
guanylate cyclase stimulator
Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. -
guanylate cyclase stimulator
Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator. -
sGC activator
Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure. -
GC-C receptor agonist
Plecanatide acetate is a guanylate cyclase-C (GC-C) receptor agonist, with an EC50 of 190 nM in T84 cells. Plecanatide acetate shows anti-inflammatory activity in models of murine colitis. -
guanylate cyclase (GC) activator
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. -
Soluble Guanylate Cyclase Stimulator
Zagociguat is a soluble guanylate cyclase (sGC) stimulator that is orally active and penetrates the blood-brain barrier. This compound enhances intracellular levels of cGMP, leading to regulation of blood pressure, improved neuronal function, reduced inflammatory responses, and neuroprotective effects. Zagociguat is primarily utilized in research focused on neurodegenerative diseases. -
sGC Activator
BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator that enhances sGC activity independent of nitric oxide. This compound exhibits significant antifibrotic properties, making it a valuable tool for research into fibrosis and related diseases. Its unique mechanism of action allows for exploration in various biological pathways associated with cardiovascular and respiratory health. -
Guanylate Cyclase-C Agonist
Plecanatide is a guanylate cyclase-C (GC-C) receptor agonist, functioning as an analogue of Uroguanylin. It effectively activates GC-C receptors, leading to the stimulation of cGMP synthesis, with an EC50 of 190 nM in T84 cell assays. Additionally, Plecanatide demonstrates anti-inflammatory activity in murine colitis models, making it useful for research into gastrointestinal disorders and related inflammatory conditions. -
sGC Inhibitor
LY83583 is a selective inhibitor of soluble guanylate cyclase (sGC), effectively modulating the cGMP signaling pathway. This compound demonstrates significant biological activity by inhibiting kinase activity associated with tumor cell proliferation, particularly through the induction of the Cdk inhibitor p21. LY83583 is applicable for research in various cancer types, including colorectal cancer, breast cancer, and melanoma, as well as in studies related to cardiovascular disease. -
sGC Activator
Ataciguat is a soluble guanylate cyclase (sGC) activator that functions independently of nitric oxide. It specifically activates the ferric heme-iron redox form of sGC, leading to increased production of cyclic GMP (cGMP). This compound demonstrates significant vasodilatory effects and is useful in research applications related to cardiovascular function and regulation of vascular tone. -
GC-C Agonist
Dolcanatide is an orally active agonist of guanylate cyclase-C (GC-C). This compound exhibits laxative, anti-nociceptive, and anti-inflammatory properties, making it suitable for various experimental applications. Dolcanatide is particularly relevant in research focused on inflammatory bowel disease. -
GC-A PAM
MCUF-651 is a positive allosteric modulator of the guanylyl cyclase A receptor (GC-A), exhibiting a binding affinity (KD) of 397 nM. This compound selectively enhances the interaction of atrial natriuretic peptide (ANP) with GC-A, leading to increased cGMP production in human cardiac, renal, and adipose tissues. Additionally, MCUF-651 demonstrates the ability to inhibit cardiomyocyte hypertrophy, making it a valuable tool for research in cardiovascular and metabolic pathways. -
pGC Agonist
Cenderitide is a potent agonist of particulate guanylyl cyclase receptors (pGC). This natriuretic peptide, composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP), activates pGC-A and pGC-B, leading to increased levels of the second messenger cGMP. Cenderitide effectively suppresses aldosterone production and helps preserve glomerular filtration rate (GFR) without causing a reduction in blood pressure. It is suitable for research applications focused on heart failure. -
Guanylate Cyclase Agonist
Linaclotide acetate is a potent and selective agonist of guanylate cyclase C, primarily involved in the regulation of intestinal fluid secretion. This compound enhances chloride and bicarbonate secretion, promoting gastrointestinal fluid accumulation and facilitating movement within the intestines. Linaclotide acetate is commonly utilized in research focused on gastrointestinal disorders, specifically for studying mechanisms and treatments related to constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation. -
Guanylate Cyclase Inhibitor
Guanylate cyclase-IN-1 is a potent inhibitor of guanylate cyclase, a crucial enzyme involved in the regulation of intracellular signaling pathways. This compound exhibits significant biological activity by modulating nitric oxide signaling, making it a valuable tool for the study of cardiovascular diseases. Its applications extend to investigating the physiological and pathological roles of guanylate cyclase in various biological processes. -
sGC Stimulator
BAY 41-8543 is a soluble guanylyl cyclase (sGC) stimulator that functions independently of nitric oxide (NO). It exhibits vasodilatory effects in both pulmonary and systemic vascular beds in rat models. Additionally, BAY 41-8543 demonstrates antiplatelet activity, making it a valuable tool for research in cardiovascular diseases. -
NPR-C Activator
NPR-C activator 1 is a potent agonist of the natriuretic peptide receptor C (NPR-C), exhibiting an EC50 of approximately 1 μM. This compound enhances the activity of C-type natriuretic peptide (CNP), which plays a crucial role in the regulation of vascular homeostasis. NPR-C activator 1 is suitable for research applications focused on cardiovascular function and the therapeutic potential of modulating NPR-C signaling. -
Guanylate Cyclase Activator
Prepro-ANF (56-92), human is a precursor of the atrial natriuretic factor and functions as a guanylate cyclase activator. This peptide enhances the activity of particulate guanylate cyclase within renal membranes and units, playing a critical role in the regulation of renal function and blood pressure homeostasis. Its application in research includes studies on cardiovascular and renal physiology, as well as investigations into natriuretic signaling pathways. -
Diguanylate Cyclases Inhibitor
Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation. -
sGC Activator
(Rac)-MGV354 is a potent soluble guanylate cyclase (sGC) activator, exhibiting EC50 values of less than 0.5 nM in CHO cells and 5 nM in GTM-3 E cells. Its ability to stimulate sGC makes it a valuable tool for investigating nitric oxide signaling pathways and their role in various biological processes. This compound is suitable for research applications focused on cardiovascular function and related signaling mechanisms. -
Intestinal Guanylate Cyclase Activator
Guanylin (human) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. It primarily regulates electrolyte and water transport in intestinal and renal epithelia via a cyclic GMP-dependent mechanism. This endogenous peptide plays a crucial role in maintaining fluid homeostasis and is vital in studies related to gastrointestinal function and renal physiology. Research applications include investigating gastrointestinal disorders and kidney function modulation. -
sGC Stimulator
BAY-747 is a soluble guanylate cyclase (sGC) stimulator that exhibits potent oral bioactivity and brain penetrance. It has been shown to reverse L-NAME-induced memory impairments, thereby enhancing cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 effectively reduces blood pressure in both normotensive and spontaneously hypertensive rat models. Furthermore, it demonstrates therapeutic potential by improving skeletal muscle function in the Duchenne muscular dystrophy (DMD) mdx/mTRG2 mouse model, making it a valuable reagent for neurological and cardiovascular research. -
sGC Stimulator
CFM 1571 hydrochloride is a potent stimulator of soluble guanylate cyclase (sGC), with an EC50 of 5.49 μM and an IC50 of 2.84 μM. This enzyme plays a critical role in the signaling pathway activated by nitric oxide (NO), which is essential for various physiological processes. CFM 1571 hydrochloride is valuable for research investigating cardiovascular conditions and other diseases linked to sGC signaling. -
Vasodilator
Ipramidil is a potent vasodilator that primarily targets the coronary circulation. It is known to significantly enhance nitric oxide (NO) release and stimulate guanylate cyclase activity, leading to improved blood flow to the heart. Due to its biological activity, Ipramidil is valuable in research focused on cardiovascular function and the mechanisms of vasodilation. -
Guanylate Cyclase Activator
Mosliciguat is a potent guanylate cyclase activator that enhances nitric oxide signaling through the stimulation of soluble guanylate cyclase. This compound exhibits key biological activities, including vasodilation and reduced blood pressure, making it relevant for cardiovascular research. Mosliciguat is primarily utilized in studies assessing pulmonary hypertension and related disorders, providing valuable insights into endothelial function and smooth muscle relaxation. -
Soluble Guanylate Cyclase Activator
BI 703704 is a potent soluble guanylate cyclase (sGC) activator that enhances intracellular signaling pathways through increased cGMP levels. It has demonstrated efficacy in inhibiting the progression of diabetic nephropathy in the ZSF1 rat model, making it a valuable tool for studying renal complications associated with diabetes. This compound is useful for research on cardiovascular and metabolic diseases, particularly those involving sGC modulation. -
sGC Activator
Avenciguat is a potent and orally active soluble guanylate cyclase (sGC) activator. By enhancing the production of cyclic guanosine monophosphate (cGMP), Avenciguat effectively improves nitric oxide (NO) signaling pathways. This compound is valuable for research on chronic kidney disease (CKD) and diabetic kidney disease (DKD), offering insights into therapeutic mechanisms and potential treatment strategies. -
sGC Activator
(Rac)-BI 703704 is a potent activator of soluble guanylyl cyclase (sGC). This compound has demonstrated the ability to mitigate renal damage progression in the ZSF1 rat model, suggesting its potential therapeutic application in diabetic nephropathy. The modulation of sGC activity may offer novel insights into the treatment of related renal disorders. -
SGC Agonist
SGC Agonist 2 is a selective agonist of soluble guanylate cyclase (SGC), an essential enzyme in the nitric oxide (NO) signaling pathway that produces cyclic GMP (cGMP). This compound demonstrates significant biological activity in modulating vasodilation and has implications for research into cardiovascular diseases, including heart failure, pulmonary hypertension, angina, and myocardial infarction, as well as fibrotic conditions such as renal fibrosis and systemic sclerosis. Its utility in investigating these pathologies makes SGC Agonist 2 a valuable tool for advancing cardiovascular and fibrosis-related research. -
Guanylate Kinase
Guanylate kinase is a key enzyme in the guanine salvage pathway, facilitating the conversion of guanosine monophosphate (GMP) and deoxyguanosine monophosphate (dGMP) through the transfer of a terminal phosphoryl group from ATP in a reversible, magnesium-dependent reaction. This enzyme plays a crucial role in nucleotide metabolism and is essential for maintaining nucleotide pools in cells. Research applications include studies on energy metabolism, synthetic biology, and the development of antiviral and anticancer therapies targeting nucleotide biosynthesis pathways. -
sGC Activator
sGC activator 1 is a potent activator of soluble guanylate cyclase (sGC), a key enzyme involved in the nitric oxide signaling pathway. By enhancing sGC activity, this compound increases intracellular levels of cyclic guanosine monophosphate (cGMP), leading to various biological effects such as vasodilation and smooth muscle relaxation. sGC activator 1 is utilized in research applications focused on cardiovascular diseases, neuroprotection, and cellular signaling mechanisms. -
NO Donor Agent
RIG 200 is an S-nitrosothiol nitric oxide (NO) donor that releases NO through decomposition, activating guanylate cyclase (sGCM) in vascular smooth muscle cells. This process increases cGMP levels, resulting in vasodilation. Additionally, RIG 200 significantly inhibits collagen-induced platelet aggregation in platelet-rich plasma (PRP), making it a valuable tool for research focused on thrombus prevention and cardiovascular studies. -
Guanylate Cyclase Activator
Nurandociguatum is a guanylate cyclase activator that enhances intracellular cGMP levels, leading to vasodilation and modulation of nitric oxide signaling. This compound is primarily utilized in cardiovascular research, particularly in studies investigating pulmonary hypertension and heart failure mechanisms. Its ability to stimulate guanylate cyclase makes it a valuable tool for exploring therapeutic strategies targeting vascular relaxation and nitric oxide pathways. -
sGC Agonist
S-3448 is a soluble guanylate cyclase (sGC) agonist that selectively activates both the heme-containing and heme-deficient forms of sGC, independent of nitric oxide and heme. This compound demonstrates significant biological activity in modulating intracellular signaling pathways related to vasodilation and cardiovascular function. S-3448 is valuable for research applications focused on cardiovascular diseases, including arterial hypertension and pulmonary hypertension, providing insights into potential therapeutic strategies. -
SGC Agonist
SGC Agonist 1 is a potent agonist of soluble guanylate cyclase (SGC), enhancing intracellular signaling pathways. It is characterized by improved solubility and high cell permeability, making it suitable for in vitro and in vivo studies. SGC Agonist 1 holds potential for research applications in cardiovascular disease, aiding in the exploration of therapeutic strategies for related conditions. -
sGC Activator
GSK2181236A is a soluble guanylate cyclase (sGC) activator that is resistant to nitric oxide. This compound promotes vasodilation, reduces mean arterial pressure, and mitigates the progression of cardiac hypertrophy. GSK2181236A is applicable in research focused on cardiovascular diseases, including hypertension and related pathologies. -
Guanylate Cyclase Activator
Guanylin (mouse, rat) is a 15-amino acid peptide that functions as an activator of intestinal guanylate cyclase. This compound plays a crucial role in regulating electrolyte and fluid balance in the intestine. Guanylin is commonly used in research related to diarrheal diseases and gastrointestinal disorders, providing insights into mechanisms of fluid secretion and absorption. -
NO Donor
SE 175 is an organic nitrate compound that functions as a nitric oxide (NO) donor through the reductive conversion of its nitrate group. Its primary mechanism involves the stimulation of endothelial soluble guanylate cyclase, resulting in pronounced aortic vasorelaxation, with an EC50 value of 0.20 µM. This compound is valuable for research investigating vascular biology and cardiovascular function, particularly in studies related to NO-mediated signaling pathways. -
Soluble Guanylate Cyclase Agonist
IWP-051 is an agonist for soluble guanylate cyclase, with an EC50 of 290 nM. It effectively stimulates the production of cyclic guanosine monophosphate (cGMP) and shows a synergistic effect with nitric oxide (NO). This compound is suitable for research focusing on cardiovascular function, smooth muscle relaxation, and other cGMP-related signaling pathways. Moreover, IWP-051 demonstrates favorable pharmacokinetic properties in rat models, making it a valuable tool for in vivo studies.
