Guanylate Cyclase

Riociguat (BAY 63-2521; BAY 632521) is a stimulator of soluble guanylate cyclase (sGC).

YC-1 is a direct activator of soluble Guanylyl Cyclase (sGC), independent of Nitric Oxide.

Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.

Linaclotide is a peptide agonist of the guanylate cyclase 2C.

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.

Vericiguat (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.

Cinaciguat is an activator of guanylate cyclase (sGC), and used for acute decompensated heart failure.

NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity.