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Catalog No.
Product Name
Application
Product Information
Citations
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MCHR1 Inhibitor
BMS-814580 is a selective melanocortin receptor 1 (MCHR1) inhibitor with a Ki of 16.9 nM against human MCHR1. This compound demonstrates significant antiobesity effects, making it a valuable tool for research into metabolic disorders and weight management. BMS-814580 can be utilized in studies exploring the role of MCHR1 in energy homeostasis and therapeutic approaches to obesity. -
Melanogenesis Inhibitory Agent
Cadin-1(14)-ene-7a,11-diol is a sesquiterpene alcohol that functions as a melanogenesis inhibitory agent. It effectively suppresses melanin production in B16 melanoma cells stimulated by α-MSH, demonstrating potential application in skin-whitening treatments. This compound is valuable for research exploring mechanisms of pigmentation and therapies for hyperpigmentation disorders. -
Melanogenesis Inhibitor
(-)-Isodocarpin is a diterpenoid that acts as a potent melanogenesis inhibitor, exhibiting an IC50 of 0.19 μM in B16 4A5 cell lines. This compound effectively suppresses the expression of key melanogenic enzymes, including tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA. (-)-Isodocarpin is valuable for research applications focused on skin pigmentation, melanin synthesis, and related dermatological studies. -
α-MSH Inhibitor
Melanostatin, frog is a potent inhibitor of α-melanocyte-stimulating hormone (α-MSH) release, exhibiting an IC50 value of 60 nM. This peptide is primarily utilized in studies investigating melanogenesis and the regulation of pigment production. Its effects on α-MSH make it a valuable tool for research applications focusing on skin biology, obesity, and related metabolic pathways. -
Melanogenesis Inhibitor
IIIM-8 is a melanogenesis inhibitor that effectively suppresses pigment production in both in vitro and in vivo models. This compound shows no cytotoxicity in Human Adult Epidermal Melanocytes (HAEM), making it a suitable candidate for research in hyperpigmentation disorders. Its mechanism of action supports studies aimed at understanding melanin synthesis and skin pigmentation regulation. -
Melanocortin Receptor Inhibitor
Chlorophorin is an inhibitor of the Melanocortin Receptor, effectively reducing tyrosinase activity and melanogenesis. This compound demonstrates significant inhibition of α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells, making it valuable for research on pigmentation disorders and melanoma. Its mechanism of action provides insights into the modulation of skin pigmentation and potential therapeutic strategies. -
Melanogenesis Inhibitor
(R)-Lirinidine is an aporphine-type alkaloid derived from Nelumbo nucifera, known for its role as a melanogenesis inhibitor. With an IC50 value of 19.3 μM, it effectively reduces melanin production, making it valuable for research in skin pigmentation disorders. Additionally, (R)-Lirinidine exhibits cytotoxic effects at concentrations of 100 μM, highlighting its potential in various biological studies. -
Melanogenesis Inhibitor
Amphistin is a melanogenesis inhibitor derived from actinomycetes. It effectively suppresses melanin production in B16 melanoma cells while demonstrating no significant impact on cellular growth. This compound is of interest for research applications focused on hyperpigmentation disorders and skin-related studies. -
Melanogenesis Inhibitor
Albocycline K3 acts as a melanogenesis inhibitor and is derived from microbial sources. This compound effectively reduces melanin production, making it suitable for research in skin biology and pigmentation disorders. Its unique mechanism of action provides valuable insights into the modulation of melanin synthesis and may aid in the development of therapies for conditions such as hyperpigmentation. -
Melanin Biosynthesis Inhibitor
Melanocin A is a potent melanin biosynthesis inhibitor that specifically targets tyrosinase, demonstrating an IC50 of 9.0 nM and a MIC of 0.9 μM. This compound effectively reduces melanin production and exhibits antioxidant properties, making it valuable for research into skin pigmentation disorders and oxidative stress-related conditions. Melanocin A can be utilized in studies examining the regulation of melanogenesis and potential therapeutic approaches for hyperpigmentation. -
ACTH Inhibitor
Delmadinone acetate is an orally active ACTH inhibitor that exerts its effects by suppressing adrenal function through the inhibition of adrenocorticotropic hormone release from the pituitary gland. This compound is primarily used in veterinary medicine for the control of estrus and ovulation in both female and male pets. Its ability to modulate endocrine functions makes it valuable for research focused on reproductive biology and hormonal regulation. -
Melanin Biosynthesis Inhibitor
Melanoxazal is an inhibitor of melanin biosynthesis. It effectively reduces melanin formation in silkworm larva hemolymph, with an IC50 of 30.1 μg/mL, and demonstrates a potent inhibitory effect on mushroom tyrosinase, exhibiting an IC50 of 4.2 μg/mL. This compound is primarily utilized in research exploring pigmentation processes and the role of melanin in various biological systems. -
mGluR2 Inhibitor
MK-8768 is a potent and selective negative allosteric modulator of the metabotropic glutamate receptor 2 (mGluR2), exhibiting an IC50 value of 9.6 nM. This compound demonstrates excellent bioavailability and brain permeability, making it suitable for investigations into neurological disorders associated with glutamate signaling. It serves as a valuable tool for research applications aimed at understanding the modulation of mGluR2 in various physiological and pathological contexts. -
mGluR Inhibitor
PF470 is a negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). It has demonstrated significant efficacy in preclinical models of Parkinson's disease, making it a valuable tool for investigating the role of mGluR5 in neurological disorders. Despite its potential, further clinical development was halted due to concerns identified in toxicology assessments. -
mGluR Inhibitor
Ro4491533 is a selective negative allosteric modulator of the mGluR2 and mGluR3 receptors. It effectively inhibits glutamate-induced calcium mobilization and decreases [35S]GTPγS binding, demonstrating its capacity to modulate glutamatergic signaling. This compound exhibits favorable pharmacokinetic properties, including high oral bioavailability and the ability to penetrate the blood-brain barrier. Additionally, Ro4491533 has shown potential in reversing motor inhibition caused by LY379268 and displays antidepressant effects in various behavioral tests such as the forced swim test and tail suspension test. -
Npr1 Inhibitor
JS11 is a selective inhibitor of natriuretic polypeptide receptor 1 (Npr1), exhibiting an IC50 of 1.9 μM for human Npr1. This compound has demonstrated the ability to alleviate pruritus in mouse models, making it a valuable tool for investigating the role of Npr1 in pruritic conditions. Its pharmacological activity positions JS11 as a significant reagent for research in dermatology and other fields related to itch sensation and regulation. -
Tachykinin/Substance P Receptor Inhibitor
CP-96,345 is a potent, non-peptide inhibitor targeting tachykinin and substance P receptors. This compound effectively inhibits the hypotensive effects induced by substance P and neurokinin A, making it a valuable tool for studying neurogenic inflammation. Its oral bioactivity allows for convenient application in research settings focused on pain modulation and inflammatory responses. -
Neurokinin Receptor Inhibitor
NK3R-IN-1 is a potent inhibitor of the Neurokinin Receptor NK3R, characterized as an imidazolepiperazine derivative with oral bioavailability. This compound effectively lowers blood luteinizing hormone levels in ovariectomized models, demonstrating significant influence on neuroendocrine regulation. It serves as a valuable tool for research in reproductive biology and neurobiology, particularly in studies involving hormone modulation and neurological signaling pathways. -
Substance P Inhibitor
[D-Pro2,D-Phe7,D-Trp9] Substance P is a synthetic analogue of Substance P that functions as a potent inhibitor of the neuropeptide. It exhibits a significant ability to modulate neurogenic inflammation and pain response by blocking Substance P-mediated signaling pathways. This compound is useful in studying the role of Substance P in pain and gastrointestinal motility research applications, particularly in models involving guinea-pig ileum contraction. -
NK1 Inhibitor
SR140333B is a selective inhibitor of the neurokinin-1 (NK1) receptor, primarily involved in modulating pain and inflammatory responses. This compound demonstrates significant efficacy in reducing LPS-induced fever and attenuating LPS-induced alterations in brain tissue in rat models. SR140333B is valuable for research focusing on neuroinflammation, pain pathways, and the therapeutic potential of NK1 receptor modulation. -
Neurokinin Receptor Inhibitor
SCH 60057 is a potent neurokinin receptor inhibitor, selectively targeting NK1 and NK2 receptors with IC50 values of 6 μM and 12 μM, respectively. This compound is derived from Acremonium sp. and is useful in research applications related to pain modulation, inflammation, and neurogenic disorders. Its ability to inhibit neurokinin signaling pathways makes it a valuable tool for investigating the roles of these receptors in various biological processes. -
Substance P Release Inhibitor
Dilopetine citrate is a potent inhibitor of substance P release, demonstrating significant activity in attenuating the vocalizations of isolated guinea pig pups in a dose-dependent manner. Its mechanisms suggest potential applications in the field of psychiatry, particularly as an antidepressant agent. This compound may facilitate research on the modulation of neuropeptide systems involved in mood regulation and pain perception. -
NK Inhibitor
Dazodeunetant is a selective inhibitor of neurokinin receptors (NK), exhibiting an IC50 of 75.99 nM against NK3R in HEK293-NK3 cells. This nitrogen-containing fused ring derivative demonstrates potential in the study of menopausal hot flashes and related therapeutic strategies. Its ability to modulate neurokinin signaling positions it as a valuable tool in neurobiology and women's health research. -
sGC Inhibitor
LY83583 is a selective inhibitor of soluble guanylate cyclase (sGC), effectively modulating the cGMP signaling pathway. This compound demonstrates significant biological activity by inhibiting kinase activity associated with tumor cell proliferation, particularly through the induction of the Cdk inhibitor p21. LY83583 is applicable for research in various cancer types, including colorectal cancer, breast cancer, and melanoma, as well as in studies related to cardiovascular disease. -
Guanylate Cyclase Inhibitor
Guanylate cyclase-IN-1 is a potent inhibitor of guanylate cyclase, a crucial enzyme involved in the regulation of intracellular signaling pathways. This compound exhibits significant biological activity by modulating nitric oxide signaling, making it a valuable tool for the study of cardiovascular diseases. Its applications extend to investigating the physiological and pathological roles of guanylate cyclase in various biological processes. -
Diguanylate Cyclases Inhibitor
Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation. -
Guanylate Cyclase Inhibitor
2-Chloro-ATP functions as a soluble guanylate cyclase inhibitor, impacting intracellular signaling pathways. This compound elevates intracellular calcium concentrations at low concentrations, utilizing a mechanism that does not rely on inositol phosphate production. It is valuable for studies investigating the role of guanylate cyclase in various physiological and pathological conditions. Researchers can utilize 2-Chloro-ATP to understand the modulation of calcium signaling in cellular processes. -
ICMT Inhibitor
ICMT-IN-1 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.0013 μM. This compound has been shown to effectively induce the accumulation of ICMT in the cytoplasm of HCT-116 cells. Additionally, ICMT-IN-1 exhibits significant antiproliferative activity against various cancer cell lines that express K-Ras and N-Ras, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-30 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.27 μM. This compound is essential for studying the role of ICMT in various biological processes, including protein modification and signaling pathways. Its inhibition can be utilized in research focused on cancer, neurodegeneration, and other diseases associated with abnormal protein prenylation. -
ICMT Inhibitor
ICMT-IN-28 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), exhibiting an IC50 value of 0.008 μM. This compound effectively disrupts the ICMT-mediated methylation of isoprenylated proteins, playing a critical role in cellular signaling pathways. ICMT-IN-28 is utilized in studies investigating the regulation of protein function and has potential applications in cancer research and other areas of cell biology. -
ICMT Inhibitor
ICMT-IN-52 is a specific inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.052 μM. This compound plays a crucial role in research on post-translational modifications and protein maturation related to oncogenesis and cellular signaling. Its ability to effectively inhibit ICMT makes it a valuable tool for studying the biological implications of ICMT activity in various disease models. -
ICMT Inhibitor
ICMT-IN-5 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.3 μM. This compound modulates protein localization and activity through the inhibition of ICMT, making it valuable for studying signal transduction pathways and post-translational modifications. ICMT-IN-5 is suitable for research applications focused on cancer biology, neurobiology, and other fields where ICMT plays a critical role in regulating protein function. -
ICMT Inhibitor
ICMT-IN-34 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.17 μM. This compound exhibits significant biological activity in the modulation of protein methylation, influencing various cellular processes. It is valuable for research applications aimed at elucidating the roles of ICMT in signal transduction and cancer biology. -
ICMT Inhibitor
ICMT-IN-51 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.55 μM. This compound is essential for studying the role of ICMT in post-translational modifications of proteins, particularly in signaling pathways related to cancer and other diseases. Its utility in biochemical assays makes it a valuable tool for researchers investigating the therapeutic potential of ICMT modulation. -
ICMT Inhibitor
ICMT-IN-7 is a potent inhibitor of isoprenylcysteine methyltransferase (ICMT), with an IC50 of 0.015 μM. This compound effectively induces the accumulation of ICMT in the cytoplasm of HCT-116 cells and demonstrates significant inhibitory effects on the proliferation of various cancer cell lines that express K-Ras and N-Ras. ICMT-IN-7 is valuable for research applications targeting ICMT-related pathways in cancer biology. -
ICMT Inhibitor
ICMT-IN-6 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.09 μM. This compound effectively disrupts ICMT activity, which plays a critical role in protein prenylation processes. ICMT-IN-6 is valuable for studying the biological implications of ICMT inhibition and its potential therapeutic applications in cancer and other diseases involving dysregulated protein prenylation. -
ICMT Inhibitor
ICMT-IN-50 is a selective inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT), with an IC50 value of 0.31 μM. This compound is utilized in research to investigate the role of ICMT in post-translational modifications and its impact on protein function and signaling pathways. Suitable for studies involving cancer biology and therapeutic development, ICMT-IN-50 provides a valuable tool for understanding ICMT's biological significance. -
ICMT Inhibitor
ICMT-IN-24 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.19 μM. This compound is utilized in research to explore the role of ICMT in post-translational modifications and its implications in various cellular processes. Its ability to inhibit ICMT makes it a valuable tool for studying protein activity and signaling pathways related to cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-15 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.032 μM. By blocking the activity of ICMT, this compound disrupts post-translational modifications of proteins involved in signaling pathways. ICMT-IN-15 is utilized in research focused on understanding the role of protein methylation in cellular processes and disease mechanisms, making it a valuable tool for studies in cancer, neurobiology, and other fields. -
ICMT Inhibitor
ICMT-IN-13 is a potent inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 of 0.47 μM. This compound is crucial for studying the role of ICMT in post-translational modifications of proteins, particularly in oncogenic signaling pathways. Its application in chemical biology can provide insights into the regulation of protein function and potential therapeutic strategies targeting cancer progression. -
ICMT Inhibitor
ICMT-IN-46 is an inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 of 0.556 μM. This compound plays a critical role in modulating protein prenylation processes, impacting various signaling pathways. It is suitable for research applications focused on cellular signaling, protein modification, and the investigation of diseases where ICMT activity is a key factor. -
ICMT Inhibitor
ICMT-IN-37 is a selective inhibitor of Isoprenylcysteine methyltransferase (ICMT), exhibiting an IC50 of 0.308 μM. This compound is instrumental for investigating the role of ICMT in various cellular processes, including protein localization and signaling pathways. Its application extends to studies on post-translational modifications and the functional implications of ICMT inhibition in cancer and other diseases. -
ICMT Inhibitor
ICMT-IN-27 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT) with an IC50 value of 0.1 μM. This compound effectively disrupts the post-translational modification of proteins that rely on ICMT activity. It is primarily utilized in studies involving protein regulation, signal transduction, and cancer research, enabling scientists to explore the role of ICMT in various biological processes. -
ICMT Inhibitor
ICMT-IN-20 is a selective inhibitor of isoprenylcysteine carboxyl methyltransferase (ICMT), with an IC50 value of 0.682 μM. This compound is instrumental in the study of post-translational modifications in proteins, facilitating research into their role in various cellular processes. ICMT-IN-20 is applicable in investigations of signal transduction pathways and may contribute to the understanding of certain diseases where ICMT activity is disrupted. -
ICMT Inhibitor
ICMT-IN-44 is a selective inhibitor of isopeptidase cyseel methyltransferase (ICMT) with an IC50 value of 0.167 μM. This compound is designed to disrupt the methylation of cyseel proteins, thereby influencing post-translational modifications and cellular signaling pathways. ICMT-IN-44 is valuable in biochemical research for studying the role of ICMT in various physiological and pathological processes, making it a useful tool in drug discovery and development. -
ICMT Inhibitor
ICMT-IN-36 is a specific inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), showing an IC50 value of 0.181 μM. This compound is valuable for researchers investigating ICMT’s role in protein modification and its implications in cancer and other diseases. Its applications include studying protein stability and signaling pathways related to post-translational modifications. -
ICMT Inhibitor
ICMT-IN-12 is a selective inhibitor of isoprenylcysteine carboxymethyltransferase (ICMT) with an IC50 value of 0.42 μM. This compound demonstrates important biological activity by blocking ICMT-mediated post-translational modifications, which play a crucial role in protein function and stability. ICMT-IN-12 is applicable in studies focusing on signaling pathways and cellular processes influenced by protein prenylation, making it a valuable tool for research in cancer biology and therapeutic development. -
ICMT Inhibitor
ICMT-IN-8 is a potent inhibitor of Isoprenylcysteine carboxyl methyltransferase (ICMT), exhibiting an IC50 value of 0.652 μM. This compound is primarily utilized in research applications focusing on protein prenylation and related signaling pathways. Investigating ICMT's role can provide insights into its potential implications in cancer and other diseases linked to dysregulated protein modification. -
ICMT Inhibitor
ICMT-IN-21 is a potent inhibitor of isoprenylcysteine O-methyltransferase (ICMT), with an IC50 value of 8.8 μM. This compound features a sulfonamide-modified farnesyl cysteine structure, with key farnesyl and carboxylic acid motifs critical for its inhibitory activity. ICMT-IN-21 is valuable for investigating the role of ICMT in post-translational modifications and cellular signaling processes, providing insights into potential therapeutic interventions. -
ICMT Inhibitor
ICMT-IN-17 is a potent inhibitor of Isoprenylcysteine Carboxyl Methyltransferase (ICMT) with an IC50 of 0.38 μM. This compound disrupts the methylation of isoprenylated proteins, which is crucial for their membrane localization and function. ICMT-IN-17 serves as a valuable tool in research aimed at understanding the role of protein methylation in various cellular processes and its implications in disease states.
