Calcium-Sensing Receptor | Adooq Bioscience

Cat. No.: A24306

CAS No.: 2387505-78-2

Calhex 231 hydrochloride

Calhex 231 hydrochloride is a potent negative allosteric modulator of the calcium-sensing receptor (CaSR), with an IC50 of 0.39 μM for inhibiting \[³H]inositol phosphate accumulation induced by CaSR activation. It transiently blocks signaling through the human wild-type CaSR and is utilized in research related to traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM), where dysregulated calcium signaling contributes to disease pathology.

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Cat. No.: A53360

CAS No.: 717104-43-3

AXT-914

AXT-914 is an inhibitor of the calcium-sensing receptor (CaSR), primarily engaged in modulating calcium signaling pathways. This compound exhibits antiviral activity against coronaviruses, including HCoV 229E and SARS-CoV-2, while also reducing cytosolic calcium signaling linked to CaSR mutations. AXT-914 is applicable in research focused on Bartter syndrome type 5, autosomal dominant hypocalcemia (ADH), and coronavirus infections.

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5 mg

$345.00

10 mg

$565.00

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Cat. No.: A59494

CAS No.: 652973-93-8

Calhex 231

Calhex 231 is a potent negative allosteric modulator targeting the calcium-sensing receptor (CaSR), exhibiting an IC50 of 0.39 μM for inhibiting increases in [3H]inositol phosphates. This compound is instrumental in research applications related to traumatic hemorrhagic shock and diabetic cardiomyopathy, providing insights into the roles of CaSR in these pathophysiological conditions. Calhex 231 offers a valuable tool for investigating the modulation of CaSR signaling pathways.

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