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adenylyl cyclase inhibitor
SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 uM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
- Adrian Hilman, .et al. , FASEB J, 2026, Mar 31;40(6):e71696 PMID: 41847922
- Ke Qian, .et al. , EBioMedicine, 2023, Dec:98:104863 PMID: 37950995
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ESI-09 is a specific exchange protein directly activated by cAMP (EPAC) inhibitor with IC50 of 3.2 uM and 1.4 uM for EPAC1 and EPAC2,
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HJC0350 is a potent and selective EPAC2 inhibitor with IC50 of 0.3 μM, exhibiting no inhibition on Epac1.
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NB001 (HTS 09836) is an adenylcyclase 1 (AC1) inhibitor which has effect on neural and non-neural pain by modulating AC1 activity.
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Inhibitor
