Fig. 1 · Structure
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LY83583
sGC Inhibitor
LY83583 is a selective inhibitor of soluble guanylate cyclase (sGC), effectively modulating the cGMP signaling pathway. This compound demonstrates significant biological activity by inhibiting kinase activity associated with tumor cell proliferation, particularly through the induction of the Cdk inhibitor p21. LY83583 is applicable for research in various cancer types, including colorectal cancer, breast cancer, and melanoma, as well as in studies related to cardiovascular disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 91300-60-6 |
| Applications | sGC Inhibitor |
| Formula | C15H10N2O2 |
| Molecular Weight | 250.26 |
| SMILES | O=C1C=C(NC2=CC=CC=C2)C(C3=C1N=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.