Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation.
Ebselen oxide is a selenone analogue that serves as a potent inhibitor of diguanylate cyclases (DGCs). By covalently modifying DGCs, it disrupts c-di-GMP-receptor interactions and subsequently decreases DGC activity. Additionally, Ebselen oxide demonstrates antibacterial properties by inhibiting alginate production in Pseudomonas aeruginosa, with an IC50 of 14 μM. It also exhibits inhibitory activity against various histone deacetylases (HDAC1 to HDAC9), with IC50 values ranging from 0.2 to 4.7 μM, making it useful for research involving epigenetic regulation.
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