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Natriuretic Peptide Receptor (NPR)

Natriuretic peptide receptor (NPR) ligands act on the receptors that mediate natriuresis and vasodilation. Atrial, B-type and C-type natriuretic peptides (ANP, BNP, CNP) bind three receptors, NPR-A, NPR-B and NPR-C. NPR-A and NPR-B are transmembrane guanylyl cyclases that make cyclic guanosine monophosphate (cGMP) rather than coupling to G proteins. A membrane guanylyl cyclase was shown in 1989 to act as an ANP receptor. NPR-C lacks a cyclase domain and was proposed in 1987 to clear natriuretic peptides from the circulation. Nesiritide acetate, a form of human BNP, and ularitide activate NPR-A. AP 811 is an NPR-C antagonist, and A 71915 is listed as an ANP antagonist.

1 Item

  • JS11
    Cat. No.
    A61958
    CAS No.
    1394592-04-1

    JS11

    JS11 is a selective inhibitor of natriuretic polypeptide receptor 1 (Npr1), exhibiting an IC50 of 1.9 μM for human Npr1. This compound has demonstrated the ability to alleviate pruritus in mouse models, making it a valuable tool for investigating the role of Npr1 in pruritic conditions. Its pharmacological activity positions JS11 as a significant reagent for research in dermatology and other fields related to itch sensation and regulation.

    In stock View Details
    5 mg
    $125.00
    10 mg
    $210.00
    All 4 sizes

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