D-Pro2,D-Phe7,D-Trp9 Substance P

Catalog No.: A62072
Substance P Inhibitor
[D-Pro2,D-Phe7,D-Trp9] Substance P is a synthetic analogue of Substance P that functions as a potent inhibitor of the neuropeptide. It exhibits a significant ability to modulate neurogenic inflammation and pain response by blocking Substance P-mediated signaling pathways. This compound is useful in studying the role of Substance P in pain and gastrointestinal motility research applications, particularly in models involving guinea-pig ileum contraction.
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5mg
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50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description[D-Pro2,D-Phe7,D-Trp9] Substance P is a synthetic analogue of Substance P that functions as a potent inhibitor of the neuropeptide. It exhibits a significant ability to modulate neurogenic inflammation and pain response by blocking Substance P-mediated signaling pathways. This compound is useful in studying the role of Substance P in pain and gastrointestinal motility research applications, particularly in models involving guinea-pig ileum contraction.
Product Information
Catalog NumA62072
FormulaC72H105N19O13S
Molecular Weight1476.79
CAS Number77275-70-8
Sequence shorteningRPKPQQFFWLM-NH2
SMILESC([C@@H](NC([C@@H](NC([C@@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC(=O)[C@@H]3N(C([C@H](CCCNC(=N)N)N)=O)CCC3)CCCCN)=O)CCC2)CCC(N)=O)=O)CCC(N)=O)=O)=O)CC4=CC=CC=C4)=O)C(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)C=5C=6C(NC5)=CC=CC6
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