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PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.26 mL | 211.3 mL | 422.6 mL |
| 0.5 mM | 8.45 mL | 42.26 mL | 84.52 mL |
| 1 mM | 4.23 mL | 21.13 mL | 42.26 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.45 mL |
*The above data is based on the productmolecular weight 236.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16833 |
|---|---|
| Actions | Activator |
| M. Wt | 236.63 |
| Formula | C6H5ClN2O4S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 38275-34-2 |
| Synonyms | PK 11007, PK-11007 |
| SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
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