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PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.
| In vitro | DMSO | 46 mg/mL (194.39 mM) | |
| Water | 46 mg/mL (194.39 mM) | ||
| Ethanol | 23 mg/mL (97.19 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 42.26 mL | 211.3 mL | 422.6 mL |
| 0.5 mM | 8.45 mL | 42.26 mL | 84.52 mL |
| 1 mM | 4.23 mL | 21.13 mL | 42.26 mL |
| 5 mM | 0.85 mL | 4.23 mL | 8.45 mL |
*The above data is based on the productmolecular weight 236.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16833 |
|---|---|
| Actions | Activator |
| CAS No. | 38275-34-2 |
| Formula | C6H5ClN2O4S |
| M. Wt | 236.63 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | PK 11007, PK-11007 |
| SMILES | CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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