PK11007

Catalog No.: A16833

p53 activator

PK11007

PK11007 Chemical Structure

CAS NO. 38275-34-2

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$80.00
50 mg
$250.00
100 mg
$420.00
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Biological Activity

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 42.26 mL 211.3 mL 422.6 mL
0.5 mM 8.45 mL 42.26 mL 84.52 mL
1 mM 4.23 mL 21.13 mL 42.26 mL
5 mM 0.85 mL 4.23 mL 8.45 mL

*The above data is based on the productmolecular weight 236.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16833
Actions Activator
M. Wt 236.63
Formula C6H5ClN2O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 38275-34-2
Synonyms PK 11007, PK-11007
SMILES CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl

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