PK11007

Catalog No.: A16833

p53 activator

PK11007

PK11007 Chemical Structure

CAS NO. 38275-34-2

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $80.00

Special Price $64.00

50 mg

Regular Price: $250.00

Special Price $200.00

100 mg

Regular Price: $420.00

Special Price $336.00

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Biological Activity

PK11007 is an anti-p53 drug that stabilizes wild type and mutant p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. It exerts antitumor functions not only via reactivating p53 but also via other cellular mechanisms, such as increase of cellular ROS to toxic levels and activation of the UPR.
In vitro DMSO 46 mg/mL (194.39 mM)
Water 46 mg/mL (194.39 mM)
Ethanol 23 mg/mL (97.19 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 42.26 mL 211.3 mL 422.6 mL
0.5 mM 8.45 mL 42.26 mL 84.52 mL
1 mM 4.23 mL 21.13 mL 42.26 mL
5 mM 0.85 mL 4.23 mL 8.45 mL

*The above data is based on the productmolecular weight 236.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A16833
Actions Activator
CAS No. 38275-34-2
Formula C6H5ClN2O4S
M. Wt 236.63
Purity >98%
Synonyms PK 11007, PK-11007
SMILES CS(=O)(=O)C1=NC=C(C(=N1)C(=O)O)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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