MRS4458

Catalog No.: A73814
Endogenous Metabolite
MRS4458 is a selective antagonist of the P2Y14 receptor, demonstrating significant anti-inflammatory activity. This compound effectively modulates neutrophil motility, contributing to its therapeutic potential in inflammatory conditions. Designed through molecular dynamic simulations, MRS4458 exhibits optimized shape and complementarity with the receptor. Its biological efficacy has been validated using fluorescence assays, confirming a robust antagonistic effect against the target receptor.
Grouped product items
Size Price Stock Qty
25mg
$1,530.00
In stock
50mg
$1,950.00
In stock
100mg
$2,480.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMRS4458 is a selective antagonist of the P2Y14 receptor, demonstrating significant anti-inflammatory activity. This compound effectively modulates neutrophil motility, contributing to its therapeutic potential in inflammatory conditions. Designed through molecular dynamic simulations, MRS4458 exhibits optimized shape and complementarity with the receptor. Its biological efficacy has been validated using fluorescence assays, confirming a robust antagonistic effect against the target receptor.
Product Information
Catalog NumA73814
FormulaC24H20F3N5O3S
Molecular Weight515.51
CAS Number2225834-49-9
SMILESO=C(C1=CC(C2=CC=C(C(NCCCN)=O)S2)=CC(N3N=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)=C1)O
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