YM-44781 free acid is a potent antagonist targeting neuropeptide receptors, specifically the NK(1) and NK(2) receptors. It demonstrates strong binding affinity for the NK(2) receptor (pKi = 9.94) and noteworthy affinity for the NK(1) receptor (pKi = 9.09). This compound has been shown to significantly inhibit bladder contractions induced by selective NK(1) receptor agonists, making it a valuable tool in research focused on neuropeptide signaling and bladder function.
YM-44781 free acid is a potent antagonist targeting neuropeptide receptors, specifically the NK(1) and NK(2) receptors. It demonstrates strong binding affinity for the NK(2) receptor (pKi = 9.94) and noteworthy affinity for the NK(1) receptor (pKi = 9.09). This compound has been shown to significantly inhibit bladder contractions induced by selective NK(1) receptor agonists, making it a valuable tool in research focused on neuropeptide signaling and bladder function.
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