Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Boc-Aminooxy-PEG3-azide is a versatile PEG-based linker utilized in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Its application in PROTAC development enables efficient targeting and degradation of specific proteins, making it valuable for research in targeted protein degradation and related fields. -
PROTAC Linker
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN functionalities, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG1-amine is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) functional group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG1-amine enhances the modularity and functionality of PROTACs, making it instrumental in targeted protein degradation research and therapeutic applications. -
PROTAC linker
endo-BCN-PEG8-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features a BCN moiety, allowing for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its high efficiency and versatility make it an essential reagent for research in targeted therapeutic strategies and cellular signaling studies. -
PROTAC Linkers
Ald-CH2-PEG8-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatility makes Ald-CH2-PEG8-azide ideal for applications in targeted protein degradation and medicinal chemistry research. -
PROTAC Linker
Carboxyrhodamine 110-PEG3-Azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that permits efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-modified partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it versatile for various click chemistry applications in chemical biology research. -
PROTAC Linker
DBCO-PEG1 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for the development of targeted protein degradation strategies in chemical biology research, facilitating the efficient assembly of bifunctional small molecules for therapeutic applications. -
PROTAC Linker
Azido-PEG8-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linkers
TCO-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a TCO (Trans-Cyclooctene) moiety that enables efficient ligation with a specific cyclopropene partner, facilitating the selective degradation of target proteins. This compound is essential for researchers developing targeted protein degradation strategies and studying cellular processes involving controlled protein levels. -
PROTAC Linkers
DBCO-PEG9-DBCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a DBCO ( dibenzocyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its ability to create covalent bonds enhances the stability and efficacy of PROTACs, making it a valuable tool for targeted protein degradation studies and drug discovery applications. -
PROTAC Linker
Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound functions through click chemistry, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique structure and reactivity make it a valuable tool for advancing research in targeted protein degradation and other applications in chemical biology. -
PROTAC Linker
Biotin-PEG2-C4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it essential for research in therapeutic protein modulation and drug discovery. -
PROTAC Linker
N-Boc-N-bis(PEG4-azide) is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it a versatile tool for chemical biology applications, including drug discovery and development. -
PROTAC Linkers
TCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a TCO (trans-cyclooctene) moiety, enabling it to participate in inverse electron demand Diels-Alder reactions with tetrazine-conjugated molecules. Its utility in click chemistry makes it a valuable tool for researchers aiming to develop innovative therapeutics targeting specific proteins for degradation. -
PROTAC Linkers
TCO-PEG24-NHS ester is a PEG-based linker designed for PROTAC synthesis, facilitating the creation of bifunctional molecules for targeted protein degradation. This compound features a TCO moiety, enabling it to engage in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing partners. It serves as a valuable tool for researchers exploring innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC linker
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based linker that facilitates the synthesis of PROTACs by incorporating a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This linker allows for the precise modification of biomolecules, enhancing their stability and solubility. It is particularly useful in the development of targeted protein degradation strategies and other chemical biology applications involving conjugation techniques. -
PROTAC Linkers
Boc-NH-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. Featuring an azide functional group, it is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) using alkyne-containing substrates or compounds with DBCO or BCN groups. This reagent is essential for the development of bifunctional molecules in targeted protein degradation research applications and facilitates the efficient assembly of PROTACs. -
PROTAC Linkers
Methyltetrazine-PEG24-amine is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. This compound is critical for researchers developing novel therapeutic strategies that leverage the ubiquitin-proteasome system to selectively eliminate unwanted proteins. Its biocompatibility and versatility make it a valuable tool in drug discovery and development. -
PROTAC Linkers
DBCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. The compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its high level of biocompatibility and efficient conjugation properties make it suitable for various applications in chemical biology and therapeutic development. -
PROTAC linker
Boc-NH-PEG9-azide is a PEG-based linker designed for usage in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for protein degradation studies and drug development applications. -
PROTAC Linker
S-Acetyl-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways via targeted ubiquitination. This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing partners. Additionally, S-Acetyl-PEG3-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-reactive molecules such as DBCO or BCN. Its applications in chemical biology are crucial for the development of innovative therapeutic strategies. -
PROTAC Linkers
(+) -Biotin-PEG6-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases and targets specific proteins for degradation, thereby enabling the study of protein function and regulation in various biological contexts. Its hydrazide moiety allows for selective conjugation, enhancing the versatility of PROTAC development in chemical biology research. -
PROTAC linker
N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties, making it useful for selective protein degradation studies and related applications in chemical biology. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based linker designed for use in PROTAC (proteolysis targeting chimeras) synthesis. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biological activity in forming stable linkages facilitates targeted proteolysis research applications, making it a valuable tool for molecular biology and drug development studies. -
PROTAC Linkers
Boc-N-Amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]nonyne (BCN) groups, making it a versatile tool for chemical research and development in targeted protein degradation studies. -
PROTAC Linkers
Pyrene azide 3 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it versatile for targeted protein degradation applications in chemical biology research. -
PROTAC linker
Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation studies and drug discovery research. -
PROTAC Linker
Boc-NHCH2CH2-PEG1-azide is a PEG-based linker specifically designed for use in synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities containing DBCO or BCN groups, facilitating the development of targeted protein degradation strategies in chemical research. -
PROTAC Linkers
DBCO-NHCO-PEG13-NHS ester is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the efficient formation of covalent linkages. Its application in PROTAC development supports targeted protein degradation studies, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Boc-NH-PEG6-azide is a PEG-based linker designed for use in PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Boc-NH-PEG6-azide is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with constructs containing DBCO or BCN groups. Its applications are pivotal in the development of targeted protein degradation strategies. -
PROTAC Linkers
Boc-N-Amido-PEG2-C2-azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound contains an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-functionalized molecules, enhancing conjugation efficiency. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it suitable for diverse bioconjugation applications in chemical biology and drug discovery. -
PROTAC Linkers
DBCO-PEG4-NH-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring a DBCO functional group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its primary application lies in the development of targeted protein degradation strategies, making it valuable in research focused on cellular regulation and therapeutic development. -
PROTAC Linkers
DBCO-PEG1-NH-Boc is a PEG-based linkerso designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a dibenzocyclooctyne (DBCO) functional group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing biomolecules. This reagent is integral in developing targeted protein degradation strategies, facilitating the specific modulation of protein levels in cellular studies. -
Ligands for E3 Ligase
(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-C2-alkyne is a conjugate consisting of an E3 ligase ligand derived from cereblon (CRBN) and a C2 alkyne linker. This reagent is designed for the synthesis of PROteolysis TArgeting Chimeras (PROTACs), facilitating targeted protein degradation pathways. Its application enables the modulation of specific protein targets, making it a valuable tool in chemical biology research. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-5-NH-C-alkyne is an E3 ligase ligand-linker conjugate featuring a terminal alkyne functional group. This compound facilitates the conjugation to target proteins, supporting the development of PROTAC (Proteolysis Targeting Chimeras) for targeted protein degradation studies. Its unique structure enables enhanced interaction with E3 ligases, making it a valuable tool for researchers investigating protein regulation and degradation pathways. -
E3 Ligase Ligand-Linker Conjugates
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe-alkyne-C6-OMs is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound effectively facilitates the recruitment of E3 ligases, enabling targeted degradation of specific proteins. Its unique linker structure and ligand properties make it a valuable tool in chemical research focused on protein modification and regulation. Use this reagent to explore novel pathways in targeted protein degradation and therapeutic development. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-alkyne-C4-NHBoc is an E3 Ligase Ligand-Linker Conjugate designed for targeted protein degradation applications. This compound facilitates the synthesis of PROTAC JAK1 degrader 1, enabling the selective degradation of the JAK1 protein. Its utility in research includes studying protein turnover and the therapeutic potential of targeted protein degradation in various diseases. -
E3 Ligase Ligand-Linker Conjugates
(S,R,S)-Me-AHPC-amide-C3-alkyne is an E3 ligase ligand-linker conjugate that facilitates the construction of targeted molecular assemblies. This compound is designed to enhance the efficacy of E3 ligase-mediated ubiquitination processes, making it invaluable for research applications in protein degradation and modulation of cellular pathways. Its utility in synthesizing compounds such as JWZ-5-13 underscores its significance in chemical biology studies involving targeted protein elimination. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-CONH-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a spacer moiety. This compound is designed for the synthesis of PROTACs (proteolysis-targeting chimeras), which facilitate targeted degradation of proteins by harnessing the ubiquitin-proteasome system. Its utility in drug discovery and therapeutic development makes it a valuable tool for researchers investigating targeted protein modulation. -
E3 Ligase Ligand-Linker Conjugate
2-(2,6-Dioxopiperidin-3-yl)phthalimidine-alkyne-piperidine is an E3 ligase ligand-linker conjugate designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a CRBN-based ligand that interacts with E3 ligases to facilitate targeted protein degradation. Its application in chemical biology enables researchers to explore novel therapeutic strategies and enhance drug development through the modulation of protein levels in various biological systems. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-NH-C2-alkyne serves as an E3 ligase ligand-linker conjugate, featuring an alkyl linker and a terminal alkyne group. This compound is designed for efficient conjugation to target proteins, facilitating the development of PROTAC (Proteolysis Targeting Chimera) research. Thalidomide-NH-C2-alkyne is instrumental in studies aimed at exploring targeted protein degradation pathways, contributing to advancements in therapeutic strategies. -
E3 Ligase Ligand-Linker Conjugate
Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate that incorporates a cereblon (CRBN) ligand and a polyethylene glycol (PEG) linker. This compound is designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs), enabling targeted degradation of specific proteins within cellular contexts. Its use is essential in research applications focusing on targeted protein degradation and the modulation of protein levels for therapeutic purposes. -
E3 Ligase Ligand-Linker Conjugate
Desamino lenalidomide-alkyne-C-piperazin is an E3 ligase ligand-linker conjugate designed for targeted protein degradation applications. This compound features a CRBN-based ligand that enables the selective recruitment of E3 ligases for the formation of PROTACs. It serves as a valuable tool for research in protein modulation and therapeutic discovery, facilitating the study of protein homeostasis and degradation pathways. -
E3 Ligase Ligand-Linker Conjugate
Pomalidomide-C3-alkyne is an E3 ligase ligand-linker conjugate that incorporates a ceramide-based ligand (CRBN) and a linker moiety, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enables selective protein degradation by harnessing the ubiquitin-proteasome system, making it valuable for studies in targeted therapy and drug development. Its utility in research applications includes investigating protein-protein interactions and exploring new therapeutic strategies for various diseases. -
PROTAC Linker
TCO-PEG3-amine is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs, enabling targeted degradation of specific proteins within cells. Its unique structure promotes solubility and stability, making it a valuable tool in chemical biology and therapeutic research applications. -
PROTAC Linker
Tetrazine-Ph-acid is a specialized linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a tetrazine moiety capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with trans-cyclooctene (TCO) derivatives, facilitating selective and efficient protein degradation. Its application in the development of PROTACs enables researchers to explore targeted protein modulation and therapeutic interventions in various biological systems. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
Ligand for E3 Ligase
Desamino lenalidomide-alkynes specifically targets cereblon (CRBN), an E3 ubiquitin ligase, facilitating the recruitment of this protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimeric molecule (PROTAC). It is instrumental in studies aimed at modulating protein levels and exploring targeted protein degradation mechanisms.
