Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Methyltetrazine-propylamine is a versatile PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This linker features an alkyl chain structure, enhancing the stability and functionality of the resulting conjugates. It is ideal for researchers focusing on targeted protein degradation and the development of innovative therapeutic modalities for various diseases. -
PROTAC Linker
DBCO-NH-Boc is a PROTAC linker featuring a dibenzocyclooctyne (DBCO) moiety that enables efficient synthesis of PROTACs through click chemistry. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, providing a versatile approach for targeted protein degradation research. Its unique structure enhances connectivity and stability, making it suitable for various applications in chemical biology and drug discovery. -
PROTAC Linker
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynyl compounds, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN-modified molecules. Its versatile reactivity makes it a valuable tool for researchers in the development of targeted protein degradation strategies. -
PROTAC Linkers
Trityl-PEG10-azide is a PEG-based linker specifically designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, Trityl-PEG10-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-modified compounds, making it a versatile tool for chemical biology applications in PROTAC development. -
PROTAC Linker
Phthalamide-PEG3-azide is a PEG-based linker designed for PROTAC synthesis. This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Its utility in these chemical reactions makes it a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
AZD-CO-C2-Ph-amido-Ph-azide is a versatile PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN moieties. This compound is essential for facilitating targeted protein degradation and advancing research in therapeutic development. -
ADC/PROTAC Linker
Propargyl-PEG5-azide is a PEG-based linker designed for antibody-drug conjugate (ADC) and PROTAC applications. This compound features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Propargyl-PEG5-azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile and effective tool for chemical biologists developing targeted therapeutics. -
PROTAC Linker
BCN-PEG4-acid is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a bicyclononyne (BCN) moiety, this compound is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use facilitates the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of drug discovery research. -
PROTAC Linkers
TCO-PEG3-amide-C3-triethoxysilane is a PEG-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimera) molecules. Its triethoxysilane group facilitates conjugation to various surfaces or substrates, enhancing the development of targeted protein degradation strategies. This compound serves as a crucial tool for researchers investigating targeted therapies and protein modulation. -
PROTAC Linkers
TCO-PEG3-TCO is a PEG-based PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the stability and solubility of PROTACs while effectively linking E3 ligases to target proteins, thereby promoting targeted protein degradation. Its applications are vital in research focused on elucidating protein functions and developing novel therapeutic strategies in cancer and other diseases. -
PROTAC linker
N-(Ac-PEG3)-N'-(azide-PEG3)-Cy7 chloride functions as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This compound features an azide functional group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties, making it a versatile tool for chemical biology applications in targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG2-amine is a PEG-based linker designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibenzocyclooctyne (DBCO) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG2-amine facilitates the development of PROTACs for targeted protein degradation applications, making it valuable in chemical biology and therapeutic research. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG3)-Cy5 serves as a PEG-based linker for PROTAC technology, facilitating the synthesis of targeted protein degraders. This compound features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it a versatile tool for researchers in the field of chemical biology and drug development. -
PROTAC Linkers
PC-PEG11-Azide is a PEG-based linker designed for use in PROTAC synthesis, facilitating targeted protein degradation. It features an Azide group that enables copper-catalyzed azide-alkyne cycloaddition reactions with alkyne-containing compounds. Additionally, PC-PEG11-Azide can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. This versatility makes it a valuable tool for chemical biology and drug discovery applications. -
PROTAC Linker
endo-BCN-PEG2-PFP ester serves as a PEG-based linker in the synthesis of PROTACs, functioning primarily through its BCN group. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, thereby enabling precise protein degradation applications. Its utility extends to various research areas, including targeted protein modulation and therapeutic development strategies. -
PROTAC Linker
Boc-NH-PEG7-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by leveraging its azide group. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-functionalized compounds and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This linker is essential for the development of targeted protein degradation strategies in chemical biology research. -
PROTAC linker
N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN moieties, facilitating efficient conjugation in chemical biology research applications. -
PROTAC Linkers
Mal-C2-cyclohexylcarboxyl-hydrazide TFA is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyl chain structure that facilitates the conjugation of target proteins and E3 ligases, enabling selective degradation of specific proteins within biological systems. It is a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. -
PROTAC Linker
Folate-PEG3-alkyne is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Folate-PEG3-alkyne is essential for developing targeted therapeutic strategies in chemical biology and drug discovery. -
PROTAC Linker
TCO-PEG4-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound serves as an effective spacer, facilitating the coupling of E3 ligase recruiters and target proteins, thereby enhancing the degradation of specific proteins in cellular assays. Its application in PROTAC development supports investigations into targeted protein degradation and therapeutic strategies in various diseases. -
PROTAC Linkers
Benzyl-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with entities bearing DBCO or BCN groups. The versatility and efficiency of Benzyl-PEG5-azide make it a valuable tool in the development of targeted protein degradation strategies and related chemical biology applications. -
PROTAC Linkers
N-PEG3-N'-(azide-PEG3)-Cy5 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this linker can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool in chemical biology and drug development research. Its application in PROTAC technology supports studies targeting protein degradation pathways for therapeutic discovery. -
PROTAC Linker
Fluorescein-thiourea-PEG4-azide is a PROTAC linker designed for the synthesis of proteolysis-targeting chimera (PROTAC) molecules. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This reagent is critical for studies focused on targeted protein degradation and can facilitate the development of innovative therapeutic strategies in chemical biology and pharmacology. -
PROTAC Linker
Boc-Aminooxy-PEG3-azide is a versatile PEG-based linker utilized in the synthesis of PROTACs (proteolysis targeting chimeras). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) derivatives. Its application in PROTAC development enables efficient targeting and degradation of specific proteins, making it valuable for research in targeted protein degradation and related fields. -
PROTAC Linker
Pyrene-amido-PEG4-azide is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). It features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing compounds. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN functionalities, making it a versatile tool for targeted protein degradation studies. -
PROTAC Linkers
DBCO-PEG1-amine is a polyethylene glycol (PEG) based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a dibenzocyclooctyne (DBCO) functional group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. DBCO-PEG1-amine enhances the modularity and functionality of PROTACs, making it instrumental in targeted protein degradation research and therapeutic applications. -
PROTAC linker
endo-BCN-PEG8-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features a BCN moiety, allowing for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its high efficiency and versatility make it an essential reagent for research in targeted therapeutic strategies and cellular signaling studies. -
PROTAC Linkers
Ald-CH2-PEG8-azide is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). It features an azide functional group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN moieties. This versatility makes Ald-CH2-PEG8-azide ideal for applications in targeted protein degradation and medicinal chemistry research. -
PROTAC Linker
Carboxyrhodamine 110-PEG3-Azide is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that permits efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-modified partners. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN derivatives, making it versatile for various click chemistry applications in chemical biology research. -
PROTAC Linker
DBCO-PEG1 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is crucial for the development of targeted protein degradation strategies in chemical biology research, facilitating the efficient assembly of bifunctional small molecules for therapeutic applications. -
PROTAC Linker
Azido-PEG8-azide is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs. It features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized partners, making it a versatile tool for applications in targeted protein degradation research. -
PROTAC Linkers
TCO-PEG6-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features a TCO (Trans-Cyclooctene) moiety that enables efficient ligation with a specific cyclopropene partner, facilitating the selective degradation of target proteins. This compound is essential for researchers developing targeted protein degradation strategies and studying cellular processes involving controlled protein levels. -
PROTAC Linkers
DBCO-PEG9-DBCO is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a DBCO ( dibenzocyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its ability to create covalent bonds enhances the stability and efficacy of PROTACs, making it a valuable tool for targeted protein degradation studies and drug discovery applications. -
PROTAC Linker
Dde Biotin-PEG4-Picolyl azide is a PEG-based PROTAC linker designed for the synthesis of targeted protein degradation agents. This compound functions through click chemistry, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its unique structure and reactivity make it a valuable tool for advancing research in targeted protein degradation and other applications in chemical biology. -
PROTAC Linker
Biotin-PEG2-C4-alkyne is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation, making it essential for research in therapeutic protein modulation and drug discovery. -
PROTAC Linker
N-Boc-N-bis(PEG4-azide) is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN groups, making it a versatile tool for chemical biology applications, including drug discovery and development. -
PROTAC Linkers
TCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a TCO (trans-cyclooctene) moiety, enabling it to participate in inverse electron demand Diels-Alder reactions with tetrazine-conjugated molecules. Its utility in click chemistry makes it a valuable tool for researchers aiming to develop innovative therapeutics targeting specific proteins for degradation. -
PROTAC Linkers
TCO-PEG24-NHS ester is a PEG-based linker designed for PROTAC synthesis, facilitating the creation of bifunctional molecules for targeted protein degradation. This compound features a TCO moiety, enabling it to engage in inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine-containing partners. It serves as a valuable tool for researchers exploring innovative therapeutic strategies in chemical biology and drug discovery. -
PROTAC linker
N-(m-PEG4)-N'-(DBCO-PEG4)-Cy5 is a PEG-based linker that facilitates the synthesis of PROTACs by incorporating a DBCO moiety that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This linker allows for the precise modification of biomolecules, enhancing their stability and solubility. It is particularly useful in the development of targeted protein degradation strategies and other chemical biology applications involving conjugation techniques. -
PROTAC Linkers
Boc-NH-PEG5-azide is a polyethylene glycol (PEG)-based linker designed for PROTAC synthesis. Featuring an azide functional group, it is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) using alkyne-containing substrates or compounds with DBCO or BCN groups. This reagent is essential for the development of bifunctional molecules in targeted protein degradation research applications and facilitates the efficient assembly of PROTACs. -
PROTAC Linkers
Methyltetrazine-PEG24-amine is a polyethylene glycol (PEG) linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimeras). Its primary mechanism involves facilitating the conjugation of target proteins with E3 ligases, enabling targeted protein degradation. This compound is critical for researchers developing novel therapeutic strategies that leverage the ubiquitin-proteasome system to selectively eliminate unwanted proteins. Its biocompatibility and versatility make it a valuable tool in drug discovery and development. -
PROTAC Linkers
DBCO-PEG8-acid is a PEG-based linker designed for use in the synthesis of PROTACs, facilitating targeted protein degradation. The compound features a DBCO group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules. Its high level of biocompatibility and efficient conjugation properties make it suitable for various applications in chemical biology and therapeutic development. -
PROTAC linker
Boc-NH-PEG9-azide is a PEG-based linker designed for usage in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for protein degradation studies and drug development applications. -
PROTAC Linker
S-Acetyl-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways via targeted ubiquitination. This compound contains an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing partners. Additionally, S-Acetyl-PEG3-azide can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-reactive molecules such as DBCO or BCN. Its applications in chemical biology are crucial for the development of innovative therapeutic strategies. -
PROTAC Linkers
(+) -Biotin-PEG6-hydrazide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the recruitment of E3 ligases and targets specific proteins for degradation, thereby enabling the study of protein function and regulation in various biological contexts. Its hydrazide moiety allows for selective conjugation, enhancing the versatility of PROTAC development in chemical biology research. -
PROTAC linker
N-(Azide-PEG3)-N'-(PEG4-acid)-Cy5 is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. It features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, this compound is capable of participating in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties, making it useful for selective protein degradation studies and related applications in chemical biology. -
PROTAC linker
N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based linker designed for use in PROTAC (proteolysis targeting chimeras) synthesis. This compound features an azide functional group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing partners, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. Its biological activity in forming stable linkages facilitates targeted proteolysis research applications, making it a valuable tool for molecular biology and drug development studies. -
PROTAC Linkers
Boc-N-Amido-PEG3-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with dibenzocyclooctyne (DBCO) or bicyclo[6.1.0]nonyne (BCN) groups, making it a versatile tool for chemical research and development in targeted protein degradation studies. -
PROTAC Linkers
Pyrene azide 3 is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It features an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-containing compounds, making it versatile for targeted protein degradation applications in chemical biology research. -
PROTAC linker
Alkyne-ethyl-PEG1-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne moiety, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide-containing molecules. Its application in PROTAC development supports targeted protein degradation studies and drug discovery research.
