TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research.
TCO-NHS ester is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). As a click chemistry reagent, it features a TCO group capable of undergoing an inverse electron demand Diels-Alder (iEDDA) reaction with tetrazine-containing molecules. This property makes TCO-NHS ester a valuable tool for the construction of complex bioconjugates and the development of targeted protein degradation strategies in chemical biology research.
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