Catalog No.
Product Name
Application
Product Information
Citations
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Anticancer/Anti-inflammatory/Anti-diabetic Agent
Phellopterin is a furocoumarin compound recognized for its anticancer, anti-inflammatory, and anti-diabetic activities. It functions as a partial agonist of central benzodiazepine receptors and demonstrates significant anti-inflammatory properties by modulating key pathways such as SIRT1 and TLR4/NF-κB, which may aid in conditions like chronic inflammation and atopic dermatitis. Additionally, Phellopterin has been shown to inhibit ovarian cancer progression through the PU.1/CLEC5A/PI3K-AKT signaling loop and promotes adipocyte differentiation, contributing to its anti-diabetic effects. This compound is valuable for research in cancer, inflammation, diabetes management, and antiviral studies. -
Anti-neuroinflammatory Agent
2-O-Methylatromentin is an anti-neuroinflammatory agent that effectively inhibits the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in lipopolysaccharide (LPS)-induced BV-2 microglial cells. This compound is valuable for research into neuroinflammatory diseases, providing insights into the mechanisms underlying inflammation in the central nervous system. Its efficacy in modulating inflammatory responses makes it a useful tool for investigating potential therapeutic strategies in neuroinflammatory conditions. -
TNF Receptor
SYLQDSVPDSFQD is an anchor-modified peptide designed for high-affinity binding to the TNF receptor, specifically DR4. This DR4-restricted MHC class II peptide is utilized in research for studying immune responses and the modulation of TNF-mediated signaling pathways. Its enhanced binding properties make it a valuable tool for investigating therapeutic strategies in inflammation and cancer research. -
COX-2 Inhibitor
Ataquimast is a selective COX-2 inhibitor that effectively suppresses the release of leukotrienes, TNF-α, and GM-CSF. Its mechanism supports research into inflammatory responses and has potential applications in the study of advanced estrogen receptor-positive breast cancer. This compound may aid in elucidating the role of COX-2 in tumor progression and therapeutic resistance. -
Selective Intranasal TLR7 Agonist
GSK2245035 maleate is a selective intranasal agonist of Toll-Like receptor 7 (TLR7), exhibiting potent Type-1 interferon (IFN) stimulating activity with pEC50 values of 9.3 for IFNα and 6.5 for TNFα. This compound effectively reduces allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is primarily utilized in research focused on asthma and other Th2-mediated allergic responses. -
Anti-inflammatory Agent
Anti-inflammatory Agent 22 is an orally active compound targeting the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production, demonstrated by an IC50 of 14.6 μM. This agent exhibits preventive effects on lymphedematous tissue by suppressing adipogenesis. Additionally, Anti-inflammatory Agent 22 has been shown to reduce limb lymphedema volume in murine models, making it a valuable tool for research into inflammatory conditions and lymphedema management. -
Anti-inflammatory Agent
Anti-inflammatory Agent 15 is a potent compound targeting inflammation through inhibition of nitric oxide synthase (iNOS). It demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with MIC50 values of 2.3 μM and 7.8 μM, respectively. This agent effectively reduces pro-inflammatory cytokines TNF-α and IL-1β, making it a valuable tool for researching tuberculosis and related inflammatory pathways. -
Anti-inflammatory Agent
3-O-Caffeoyl-5-O-feruloylquinic acid is a phenolic compound with potent anti-inflammatory properties, primarily targeting free radical scavenging mechanisms. It effectively regulates inflammatory pathways by inhibiting TNF-α-induced production of reactive oxygen species (ROS) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs). This compound is valuable in research applications focused on oxidative stress and inflammation pathways, offering insights into potential therapeutic strategies for inflammatory disorders. -
COX-2 Inhibitor
COX-2-IN-60 is a potent and selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating an IC50 of 0.06 μM and approximately 100-fold selectivity over COX-1. This compound significantly reduces oxidative stress and neuroinflammatory cytokines, effectively counteracting epileptogenesis. In preclinical studies utilizing a pilocarpine-induced seizure mouse model, COX-2-IN-60 exhibited substantial anticonvulsant effects while protecting against hippocampal injury. Its application in research relates to neuroinflammatory pathways and epilepsy mechanisms. -
TLR Inhibitor
ETI60 is a selective Toll-like receptor (TLR) inhibitor that primarily targets the nucleoside-binding Site I on TLR7 and TLR9, with IC50 values of 0.68 μM and 0.12 μM, respectively. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, demonstrating nanomolar activity in cellular, biophysical, and in vivo assays. ETI60 modulates the expression of inflammation-related genes and has shown efficacy in alleviating symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). This reagent is valuable for research involving autoimmune and inflammatory diseases. -
Anti-inflammatory Agent
Anti-inflammatory agent 104 is a potent anti-inflammatory compound that specifically inhibits TNF-α synthesis and release in the human macrophage cell line U937, with an IC50 value of 0.024 nM. This agent demonstrates significant biological activity by reducing eosinophil levels in rat lungs by 63%, making it a valuable tool for studying inflammatory responses and evaluating therapeutic strategies in related research applications. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Keap1/Nrf2/ARE Activator
Keap1/Nrf2/ARE Activator 2 is a potent activator of the Keap1/Nrf2/ARE signaling pathway, promoting Nrf2 nuclear translocation. This compound has been demonstrated to upregulate antioxidant genes, thereby enhancing cellular defense against oxidative stress. Additionally, it exhibits significant neuroprotective effects against H2O2- and Scopolamine-induced neuronal injury in PC12 cells, as well as alleviating memory impairment and neuroinflammation associated with cognitive dysfunction in zebrafish models. Keap1/Nrf2/ARE Activator 2 is a valuable tool for research into Alzheimer's disease and associated neurodegenerative conditions. -
Anti-inflammatory Agent
Siaresinolic acid is an anti-inflammatory compound derived from the leaves of Sabicea grisea. It exhibits significant antinociceptive properties by modulating ATP-dependent potassium channels and inhibiting the influx of leukocytes, plasma leakage, and the production of pro-inflammatory mediators such as TNF-α and IL-1β. Importantly, Siaresinolic acid demonstrates a lack of cytotoxicity in murine macrophages and does not affect locomotor activity even at elevated doses. This compound is suitable for research applications involving pleurisy and pain management. -
Anti-inflammatory agent
Taxamairin B is a potent anti-inflammatory agent that targets proinflammatory cytokine production. It effectively reduces the expression of TNF-α, IL-1β, and IL-6, as well as the oxidative stress markers nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW264.7 macrophage cells. Additionally, Taxamairin B demonstrates significant protective effects in models of LPS-induced acute lung injury in mice, making it a valuable compound for research on inflammatory pathways and potential therapeutic applications. -
Anti-inflammatory Agent
Oleracone is an alkaloid derived from Portulaca oleracea L. that functions as an anti-inflammatory agent. It demonstrates potent anti-inflammatory effects in the RAW 264.7 macrophage model, effectively inhibiting nitric oxide production and reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone is suitable for researching inflammatory diseases and exploring potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
Proinflammatory Cytokine Inhibitor
Semapimod is a potent inhibitor of proinflammatory cytokine production, targeting Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM. It effectively inhibits the production of key cytokines such as TNF-α, IL-1β, and IL-6, as well as p38 MAPK activity and nitric oxide production in macrophages. This compound holds promise for research in various inflammatory and autoimmune disorders. -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Anti-inflammatory Agents
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that acts as an anti-inflammatory agent by inhibiting the production of TNF-α. It exhibits both anti-inflammatory and antibacterial properties, making it a valuable tool for researching inflammatory diseases and potential therapeutic interventions. Its mechanism of action opens avenues for studies related to immune response modulation and pathogen resistance. -
NO、TNF-α、IL-12 Inhibitor
(R)-5,7-Dimethoxyflavanone acts as an inhibitor of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-12 (IL-12), demonstrating significant anti-inflammatory properties. In biological assays, this compound exhibits potent antimutagenic activity, effectively reducing MeIQ-induced mutagenesis in the Ames test using S. typhimurium strains TA100 and TA98. Its capacity to modulate inflammatory mediators makes it a valuable tool in research focused on inflammation and mutagenesis. -
TLR Inhibitor
ETI41 is a selective Toll-like receptor (TLR) inhibitor that targets the nucleoside-binding Site I on TLR7 and TLR9, demonstrating IC50 values of 0.63 μM and 0.16 μM, respectively, while sparing surface TLRs. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, displaying potent nanomolar activity across cellular, biophysical, and in vivo assays. ETI41 suppresses the expression of inflammation-associated genes and improves symptoms in murine models of psoriasis and systemic lupus erythematosus (SLE). It is valuable for research into autoimmune and inflammatory diseases. -
Anti-inflammatory Agent
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 17 is a potent orally active compound that targets inflammatory pathways by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α. In vitro studies demonstrate its ability to reduce inflammation without inducing cytotoxicity. Additionally, anti-inflammatory agent 17 exhibits significant anti-inflammatory activity in vivo, making it a valuable tool for research into acute lung injury (ALI) and other inflammatory conditions. -
Anti-CD274/TNFRSF9 Antibody
Solabafusp alfa is a humanized IgG4κ type antibody that specifically targets CD274 (also known as PD-L1) and TNFRSF9 (also known as 4-1BB). This compound is significant for its potential to modulate immune responses, making it a valuable tool in cancer research and immunotherapy studies. It can be utilized to explore pathways related to immune checkpoint inhibition and T-cell activation. An appropriate isotype control for this antibody is Human IgG4 (S228P) kappa. -
Anti-inflammatory Agent
CX-659S is an orally active 5-carboxamide uracil derivative with anti-inflammatory properties. It effectively inhibits lipid peroxidation with an IC50 of 5.9 μM and reduces the infiltration of neutrophils and eosinophils. CX-659S also inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α, making it a valuable tool for research on inflammatory conditions. -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
Monoterpenoids
Neral is a monoterpene compound that exhibits anti-inflammatory and anti-cancer properties. It functions by inhibiting pro-inflammatory cytokines such as TNF-α and IL-6, and it downregulates key inflammatory mediators including pro-IL-1β, iNOS, COX-2, and NLRP-3. Neral's biological activities make it valuable for research in inflammation and cancer treatment strategies. -
TLR9 Antagonist
TLR9 antagonist 1 is a selective toll-like receptor 9 (TLR9) antagonist that exhibits an IC50 of 0.1 nM for human TLR9, demonstrating a significant preference over TLR2, TLR4, TLR5, TLR7, and TLR8. This compound is known to exacerbate symptoms in systemic lupus erythematosus (SLE) mouse models by increasing levels of anti-dsDNA and anti-Sm antibodies. TLR9 antagonist 1 is valuable for research in inflammatory and autoimmune diseases, particularly in the study of disorders such as lupus and arthritis. -
STING Agonist
STING Agonist-45 is a selective agonist of the stimulator of interferon genes (STING), exhibiting an EC50 value of 0.28 μM. It activates the innate immune response via the cGAS-STING pathway, leading to the upregulation of critical markers such as p-TBK1 and IRF3. STING Agonist-45 effectively stimulates the production of type I interferons, including IFN-β, as well as cytokines like TNF-α and IL-6 in human peripheral blood mononuclear cells (PBMCs). This compound shows potential in enhancing anti-tumor immunity, inhibiting tumor growth, and promoting CD8+ T cell infiltration in animal models, making it a valuable tool for research into STING-related diseases. -
Anti-inflammatory Agent
Desoxo-narchinol A is a potent anti-inflammatory agent that is derived from the roots and rhizomes of Nardostachys jatamansi. This compound exhibits significant biological activity, making it a valuable tool for research into septic shock and various inflammatory diseases. Its oral activity further enhances its applicability in preclinical studies, providing insight into therapeutic strategies for managing inflammation-related conditions. -
CSE1L/PD-L1 Inhibitor
Naamidine J is an imidazole-type alkaloid that functions as a CSE1L/PD-L1 inhibitor. It demonstrates significant anti-inflammatory activity by reducing pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6, while enhancing the expression of anti-inflammatory markers like CD206 and Arg-1. Additionally, Naamidine J exhibits antitumor properties and alleviates pulmonary tissue edema and inflammatory infiltrates in murine models. This compound is valuable for research focused on the immune microenvironment in the contexts of acute lung injury and cancer. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics. -
CD206 Targeting Peptide
RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF). -
Anti-inflammatory Agent
Shizukaol B is an anti-inflammatory agent derived from the lindenane-type dimeric sesquiterpene found in Chloranthus henryi. This compound demonstrates significant inhibitory effects against lipopolysaccharide (LPS)-induced activation of BV2 microglial cells, effectively reducing nitric oxide production and downregulating the expression of pro-inflammatory markers such as iNOS, COX-2, TNF-α, and IL-1β. Shizukaol B is suitable for research applications focused on neuroinflammation and related therapeutic strategies. -
TLR3/9 Inhibitor
M199 is a selective inhibitor of TLR3 and TLR9 signaling pathways. This compound effectively induces the secretion of pro-inflammatory cytokines, including IL-6, IL-8, and TNFα, in human peripheral blood mononuclear cells (PBMCs). M199 is utilized in research to investigate immune response modulation and the role of TLR signaling in various biological processes. -
Anti-inflammatory Agent
Chloranthalactone B is a lindenane-type sesquiterpenoid that functions as an anti-inflammatory agent. Isolated from the Chinese medicinal herb Sarcandra glabra, this compound effectively inhibits the production of inflammatory mediators by targeting the AP-1 and p38 MAPK signaling pathways. Its role in modulating inflammation makes it a valuable tool for research in inflammation-related studies and therapeutic applications. -
CD27 Agonist
MG-C-30 is a potent oral agonist of CD27, demonstrating an EC50 of 0.84 μM. This compound activates natural killer (NK) cells and enhances T cell co-stimulatory signals, thereby augmenting the immune response. MG-C-30 has also shown significant antitumor efficacy in the EG7-OVA mouse model, making it a valuable tool for research in immunotherapy and cancer treatment. -
Anti-neuroinflammatory Agent
Grossamide is a natural compound extracted from the dried fruit of Cannabis sativa L. Its primary mechanism involves anti-neuroinflammatory activity, making it a valuable agent for research into neuroinflammatory conditions. Grossamide has potential applications in studies focused on neuroprotection and inflammation-related pathways in the nervous system. -
Anti-inflammatory Agent
EM-163 is an anti-inflammatory agent that selectively targets the TIR domain of MyD88. By intervening in the inflammatory signaling pathways, EM-163 has demonstrated efficacy in alleviating inflammation and protecting against toxic shock. This compound is particularly relevant for research related to Staphylococcal enterotoxin B (SEB) poisoning, providing a valuable tool for investigators studying inflammatory responses and potential therapeutic interventions. -
Geraniol Derivative
Geranial, a derivative of geraniol, primarily targets inflammatory pathways. It exhibits anti-inflammatory activity by inhibiting the secretion of pro-inflammatory cytokines such as TNF-α and IL-6 from macrophages. Additionally, Geranial inhibits IL-1β secretion via the NLRP-3 inflammasome, making it a valuable tool for research focused on inflammation and immune response modulation. -
Anti-Inflammatory Agent
Skimmin, a glucoside of umbelliferone, is primarily recognized for its anti-inflammatory properties. Extracted from Hydrangea paniculata, this compound exhibits renal protective effects by enhancing creatinine clearance and mitigating kidney injury. Additionally, Skimmin demonstrates significant anti-amoebic activity against Entamoeba histolytica, as well as anti-cancer and neuroprotective effects. Its influence on cardiac health is evident through the reduction of fibrosis and the modulation of inflammatory cytokines, including TNF-α and IL-6. Skimmin serves as a valuable research tool in the study of diabetes and associated metabolic disorders. -
Anti-inflammatory Agent
1,4-Dicaffeoylquinic acid is a phenylpropanoid compound that functions as an anti-inflammatory agent through the inhibition of xanthine oxidase, with an IC50 of 7.36 μM. This compound effectively reduces inflammation by inhibiting the production of TNF-α induced by lipopolysaccharides (LPS). Its role in modulating inflammatory responses makes 1,4-Dicaffeoylquinic acid a valuable tool for research in inflammation-related studies. -
Selective Intranasal TLR7 Agonist
GSK2245035 is a selective intranasal agonist for Toll-Like Receptor 7 (TLR7), exhibiting potent Type-1 interferon (IFN) stimulation, with pEC50 values of 9.3 for IFNα and 6.5 for TFNα. This compound demonstrates efficacy in suppressing allergen-induced Th2 cytokine production in human peripheral blood cell cultures, making it a valuable tool for asthma research. Its unique mechanism of action highlights its potential in studying immune responses and therapeutic applications in allergic conditions. -
Anti-inflammatory Agent
9-Methoxycanthin-6-one, an alkaloid derived from canthin-6-one, acts as an anti-inflammatory agent. This compound demonstrates notable anti-tumor activity and effectively inhibits LPS-induced production of pro-inflammatory cytokines such as TNF-α and IL-1β. It is utilized in research applications focused on inflammation and tumor biology. -
Anti-inflammatory Agents
(±)-Perillaldehyde is an anti-inflammatory agent that demonstrates significant biological activity by inducing JNK activation in RAW264.7 cells. This compound inhibits the expression of TNF-α, with an IC50 value of 171.7 μM, highlighting its potential in modulating inflammatory responses. Additionally, (±)-Perillaldehyde exhibits antidepressant effects through its action on the olfactory nervous system, making it relevant for research into stress-related disorders. -
GPRC5D/CD3ε/TNFRSF17 Antibody
Ramantamig is a humanized monoclonal antibody that targets CD3ε on T cells, as well as GPRC5D and TNFRSF17 (BCMA) on multiple myeloma cells. It facilitates T-cell-mediated cytotoxicity by forming immunological synapses, leading to selective killing of myeloma cells without non-specific T-cell activation when target cells are absent. Additionally, Ramantamig has been engineered to minimize interactions with Fc receptors, enhancing its specificity. This reagent is ideal for research in multiple myeloma therapies. -
Anti-inflammatory Agent
7,3',4'-Tri-O-methylluteolin is a flavonoid that acts as an anti-inflammatory agent by inhibiting soybean lipoxygenase (LOX), with an IC50 value of 23.97 µg/mL. This compound demonstrates significant anti-inflammatory effects in LPS-induced RAW 264.7 macrophages and has been shown to inhibit the MDM2-p53 binding, thereby inducing apoptosis in MCF-7 breast cancer cells. Furthermore, 7,3',4'-Tri-O-methylluteolin exhibits antioxidant, antifungal, and antitrypanosomal properties, making it valuable for various biological research applications. -
TLR4 Activator
Kdo2-Lipid A ammonium is a selective TLR4 activator known for its potent endotoxin activity comparable to that of lipopolysaccharide (LPS). It effectively stimulates the release of pro-inflammatory mediators, including tumor necrosis factor (TNF) and prostaglandin E2 (PGE2). This compound is widely utilized in immunological research to investigate TLR4 signaling pathways and the associated inflammatory responses. -
Anti-inflammatory Agent
Episappanol is a natural compound derived from the heartwood of Caesalpinia sappan, functioning primarily as an anti-inflammatory agent. It effectively inhibits the secretion of pro-inflammatory cytokines, including IL-6 and TNF-α. This compound is valuable for research applications aimed at exploring inflammation-related pathways and potential therapeutic interventions for inflammatory diseases.
