Burixafor is a selective antagonist of the CXCR4 receptor that effectively inhibits the binding of CXCL12, with a pIC50 of 7.4. This compound disrupts CXCL12-induced recruitment of Gαᵢ and β-arrestin2, further blocking the Gαᵢ-mediated inhibitory effects on cAMP signaling pathways. Burixafor is instrumental in mobilizing CD34+ hematopoietic stem/progenitor cells from the bone marrow to peripheral blood, making it valuable for research applications in autologous hematopoietic stem cell transplantation.
Burixafor is a selective antagonist of the CXCR4 receptor that effectively inhibits the binding of CXCL12, with a pIC50 of 7.4. This compound disrupts CXCL12-induced recruitment of Gαᵢ and β-arrestin2, further blocking the Gαᵢ-mediated inhibitory effects on cAMP signaling pathways. Burixafor is instrumental in mobilizing CD34+ hematopoietic stem/progenitor cells from the bone marrow to peripheral blood, making it valuable for research applications in autologous hematopoietic stem cell transplantation.
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