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EPI-X4

Catalog No.: A59781
CXCR4 Antagonist
EPI-X4 is a selective antagonist of the C-X-C motif chemokine receptor 4 (CXCR4), exhibiting an IC50 of 8.6 μM. This compound effectively inhibits CXCL12-mediated signaling and reduces chemokine-driven migration and invasion in leukemia cells. Additionally, EPI-X4 demonstrates anti-inflammatory properties in mouse models and displays antiviral activity against CXCR4-tropic HIV, making it a valuable tool for research in cancer, inflammation, and virology.
EPI-X4 930280-31-2 CXCR4 Antagonist
Grouped product items
Size Price Stock Qty
5mg
$75.00
In stock
10mg
$120.00
In stock
25mg
$220.00
In stock
50mg
$320.00
In stock
100mg
$470.00
In stock
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Free Delivery on orders over $500
Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionEPI-X4 is a selective antagonist of the C-X-C motif chemokine receptor 4 (CXCR4), exhibiting an IC50 of 8.6 μM. This compound effectively inhibits CXCL12-mediated signaling and reduces chemokine-driven migration and invasion in leukemia cells. Additionally, EPI-X4 demonstrates anti-inflammatory properties in mouse models and displays antiviral activity against CXCR4-tropic HIV, making it a valuable tool for research in cancer, inflammation, and virology.
Product Information
Catalog NumA59781
FormulaC84H144N22O23
Molecular Weight1830.18
CAS Number930280-31-2
SequenceLeu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu
Sequence shorteningLVRYTKKVPQVSTPTL
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)N)=O)[C@H](C)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CCCCN)=O)[C@@H](C)C)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)[C@@H](C)O)=O)CCC3)[C@@H](C)O)=O)CO)=O)[C@H](C)C)=O)CCC(N)=O)=O)CCC2
SynonymshSA(408–423) peptide
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Autophagy Signaling > CXCR
Immunology & Inflammation > CXCR
GPCR/G Protein > CXCR