(R,R)-CXCR2-IN-2 is a selective antagonist of the CXCR2 receptor, exhibiting a robust pIC50 of 9 in the Tango assay and 6.8 in the HWB Gro-α induced CD11b expression assay. This compound demonstrates significant inhibition of CXCR2-mediated signaling pathways, making it a valuable tool for research into inflammatory responses and immune cell migration. Its modulation of CXCR2 activity is pertinent for studies aimed at understanding various disease states, including cancer and chronic inflammatory conditions.
(R,R)-CXCR2-IN-2 is a selective antagonist of the CXCR2 receptor, exhibiting a robust pIC50 of 9 in the Tango assay and 6.8 in the HWB Gro-α induced CD11b expression assay. This compound demonstrates significant inhibition of CXCR2-mediated signaling pathways, making it a valuable tool for research into inflammatory responses and immune cell migration. Its modulation of CXCR2 activity is pertinent for studies aimed at understanding various disease states, including cancer and chronic inflammatory conditions.
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