(±)-NBI-74330 is a potent and selective antagonist of the chemokine receptor CXCR3. This compound is effective in alleviating tactile and thermal hypersensitivity and demonstrates the ability to enhance the analgesic effects of morphine. In a rat neuropathic pain model, (±)-NBI-74330 reduces microglial cell activation, promotes astroglial cell activation, and downregulates specific CXCR3 ligands, making it a valuable tool for research in pain modulation and neuroinflammation.
(±)-NBI-74330 is a potent and selective antagonist of the chemokine receptor CXCR3. This compound is effective in alleviating tactile and thermal hypersensitivity and demonstrates the ability to enhance the analgesic effects of morphine. In a rat neuropathic pain model, (±)-NBI-74330 reduces microglial cell activation, promotes astroglial cell activation, and downregulates specific CXCR3 ligands, making it a valuable tool for research in pain modulation and neuroinflammation.
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