Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
3-Demethylcolchicine is an anti-inflammatory agent known for its potent tubulin-binding activity. This colchicine metabolite effectively inhibits carrageenan-induced edema in rat paw models, making it valuable for research into inflammatory responses. Additionally, the presence of a hydroxyl group on its carbocyclic ring enhances its ability to scavenge free radicals, contributing to its therapeutic potential. 3-Demethylcolchicine serves as a key reagent in studies focused on inflammation and oxidative stress. -
COX-2 Inhibitor
Hexahydrocurcumin is a selective, orally active inhibitor of cyclooxygenase-2 (COX-2), demonstrating significant potential in anti-inflammatory applications. As one of the primary metabolites of curcumin, it exhibits antioxidant and anticancer properties, making it relevant for research in various therapeutic areas. Its selectivity towards COX-2 over COX-1 highlights its potential for minimizing gastrointestinal side effects often associated with non-steroidal anti-inflammatory drugs (NSAIDs). -
Nrf2 Activator
Nrf2 activator-4 is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. This compound effectively suppresses reactive oxygen species related to oxidative stress in microglial cells. Additionally, Nrf2 activator-4 demonstrates the ability to recover learning and memory impairments in a scopolamine-induced mouse model, making it a valuable tool for research focused on neuroprotection and cognitive function. -
KEAP1-NRF2 Inhibitor
Keap1-Nrf2-IN-14 is a potent inhibitor of the KEAP1-NRF2 interaction, exhibiting an IC50 value of 75 nM and a Kd of 24 nM for KEAP1. This compound promotes the expression of NRF2 target genes, resulting in enhanced antioxidant and anti-inflammatory responses. Keap1-Nrf2-IN-14 is valuable for investigating oxidative stress-related inflammation and exploring therapeutic strategies targeting the KEAP1-NRF2 signaling pathway. -
Anti-inflammatory compound
U-83836E is an anti-inflammatory compound that exhibits both anti-inflammatory and antioxidant activities. It effectively reduces lung inflammation by inhibiting oxidative stress and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on asthma and lung inflammation in various animal models. -
Anti-inflammatory Agent
Kumujian A (1-Ethoxycarbonyl-β-carboline) is an anti-inflammatory agent that effectively inhibits superoxide anion generation with an IC50 of 4.87 μg/mL and elastase release with an IC50 of 6.29 μg/mL. This compound is valuable for research applications focused on understanding inflammation pathways and developing potential therapeutic strategies for inflammatory diseases. -
Nonsteroidal Anti-inflammatory Agent
Feprazone is a nonsteroidal anti-inflammatory agent that targets cyclooxygenase-2 (COX-2), exhibiting significant analgesic and antipyretic properties. This compound has been shown to mitigate oxidative stress induced by free fatty acids by reducing mitochondrial reactive oxygen species (ROS) production. Additionally, Feprazone inhibits the expression of matrix metalloproteinases MMP-2 and MMP-9, while suppressing adipogenesis and promoting lipolysis in differentiating 3T3-L1 adipocytes. It is valuable for research applications focused on atherosclerosis and obesity. -
Anti-Inflammatory Compound
Dapsone hydroxylamine (DDS-NOH) is an anti-inflammatory compound that primarily targets catalase (CAT) activity. It inhibits CAT activity and reduces the generation of reactive oxygen species, contributing to its anti-inflammatory properties. Dapsone hydroxylamine is utilized in research applications focused on oxidative stress and inflammation modulation. -
Anti-Neuroinflammatory Agent
LZWL02003 is an anti-neuroinflammatory agent that targets neuroinflammatory pathways. It demonstrates protective effects against MPP+-induced neuronal damage and significantly reduces reactive oxygen species (ROS) levels. Additionally, LZWL02003 enhances cognitive functions such as memory, learning, and physical performance in a Rotenone-induced parkinsonism model in rats. This compound is valuable for research into neurodegenerative diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
3′-Oxolutein is an anti-inflammatory agent and a metabolite of dietary lutein. It effectively reduces glutamate-induced reactive oxygen species (ROS) production and pro-inflammatory cytokine secretion in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels while enhancing thiol concentrations. This compound is suitable for research focused on inflammation and oxidative stress responses. -
Anti-inflammatory Agent
Pholidotol C is a stilbene compound that serves as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. It demonstrates significant antioxidant properties, with IC50 values of 28.6 μM for NO production and 21.9 μM for DPPH free radical scavenging. Pholidotol C's mechanisms include the inhibition of NO production in activated macrophages and effective free radical scavenging. This compound is valuable for research in inflammation-related diseases and can be extracted from the dried whole plant of Pholidota chinensis. -
COX-2 Inhibitor
COX-2-IN-65 is a selective inhibitor of cyclooxygenase-2 (COX-2) with a reported IC50 of 10.24 μM. This compound exhibits antibacterial activity against Staphylococcus aureus and Escherichia coli, while also scavenging reactive oxygen species (ROS). COX-2-IN-65 is valuable for research applications focused on bacterial infections and inflammation pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
ROS Inhibitor
Picrasidine A is a potent reactive oxygen species (ROS) inhibitor derived from the natural product Picrasma quassioides. This compound demonstrates the ability to inhibit UVB-induced ROS generation, making it a valuable tool for research in oxidative stress and related cellular responses. Its applications extend to studies investigating the protective effects against UV radiation and the underlying mechanisms of antioxidative pathways. -
NRF2 Activator
BC-1901S is a proteasome-independent activator and stabilizer of NRF2. It functions by binding to DCAF1, an E3 ligase subunit, disrupting the NRF2/DCAF1 interaction, and inhibiting NRF2 ubiquitination through a KEAP1-independent pathway. BC-1901S demonstrates anti-inflammatory effects in murine models of LPS-induced acute lung injury, making it a valuable tool for research into NRF2-related pathways and inflammation. -
IKZF Degrader
BMS-986482 is a CRBN-mediated IKZF degrader that selectively targets the IKZF1-4 protein family. Its unique CELMoD™ core facilitates the degradation of these proteins, leading to impaired tumor growth as demonstrated in preclinical mouse models. This compound is particularly valuable for research focused on advanced solid tumors, providing insights into therapeutic strategies that disrupt IKZF protein function. -
Anti-Inflammatory Agent
Comanthoside B is a flavonoid glycoside derived from the aerial parts of Ruellia tuberosa L. It exhibits significant anti-inflammatory and antiseptic properties, making it a valuable reagent for studies focused on inflammation-related pathways. Its biological activity supports its use in exploring therapeutic strategies for inflammatory conditions. -
Anti-inflammatory agent
Hentriacontane is a long-chain alkane that acts as an anti-inflammatory agent by inhibiting the NF-κB signaling pathway. Its bioactivity encompasses not only anti-inflammatory effects but also antitumor and antibacterial properties. This compound is valuable for research applications focused on inflammation modulation, cancer biology, and antimicrobial studies. -
Nonsteroidal Anti-inflammatory Agent
Oxyphenbutazone monohydrate is a nonsteroidal anti-inflammatory agent that functions as a non-selective inhibitor of cyclooxygenase (COX). It exhibits significant anti-inflammatory properties, making it a valuable reagent in pharmacological research. Additionally, Oxyphenbutazone monohydrate has been shown to selectively target and eliminate non-replicating Mycobacterium tuberculosis, highlighting its potential in tuberculosis research and therapy development. -
Anti-inflammatory Agent
5'-Methoxynobiletin is a polymethoxyflavone that acts as a potent anti-inflammatory agent. Isolated from A. conyzoides, this compound exhibits significant antinociceptive properties, making it valuable for research focused on pain management and inflammation. Its efficacy in modulating inflammatory pathways positions it as an important tool for scientists investigating anti-inflammatory mechanisms and therapeutic applications. -
Anti-inflammatory compound
Batatasin I is an anti-inflammatory compound derived from the tuberous roots of Dioscorea batatas. This natural product exhibits notable antifungal activity and has been shown to modulate inflammatory processes. Batatasin I is applicable in research focused on inflammatory diseases and may serve as a lead compound for the development of new therapeutic agents in this area. -
Anti-inflammatory Agent
Methylarbutin functions as an anti-inflammatory agent, demonstrating significant anti-inflammatory properties. It has been shown to possess urinary antiseptic activity, making it a useful compound in research focused on inflammatory conditions and urinary tract health. Methylarbutin can be utilized in studies aimed at elucidating mechanisms involved in inflammation and infection. -
Anti-inflammatory/immunomodulator
Isozaluzanin C is a dehydrozaluzanin C derivative that acts as an anti-inflammatory agent and immunomodulator. Isolated from Saussurea lappa, it has demonstrated the ability to ameliorate tissue damage in various organs, including the lung, kidney, and liver, in murine models of LPS-induced or CRKP infection. This compound is valuable for research on bacterial infections and sepsis, providing insights into the mechanisms underlying inflammatory responses. -
Anti-inflammatory Agent
Dihydromyristicin is a plant-derived flavonoid known for its potent anti-inflammatory effects. It exerts its biological activity by attenuating endotoxic inflammation through the suppression of reactive oxygen species (ROS)-mediated activation of the PI3K/Akt/NF-κB signaling pathways. This compound is valuable in research applications focusing on inflammation-related studies and potential therapeutic interventions. -
ROS Inducer
ROS Inducer 3 (Compound I6) primarily functions as a reactive oxygen species (ROS) inducer. It demonstrates significant in vitro bioactivity with an EC50 of 2.86 μg/mL, showcasing robust protective effects against Pseudomonas syringae pv. actinidiae. As a bactericidal agent, ROS Inducer 3 is relevant for studies focused on managing persistent plant bacterial diseases. -
Anti-Inflammatory Agent
Linocinnamarin is a natural product derived from Fragaria ananassa Duch and functions as an anti-inflammatory agent. It demonstrates significant anti-inflammatory activity by inhibiting the antigen-stimulated increase in intracellular free Ca2+ concentration and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on inflammation pathways and the potential therapeutic effects of natural anti-inflammatory substances. -
ROS Inducer
ROS Inducer 2 (Compound I16) primarily functions as a reactive oxygen species (ROS) inducer, demonstrating significant in vitro bioactivity with an EC50 of 3.43 μg/mL. This compound exhibits potent bactericidal properties against Xanthomonas axonopodis pv. citri in vivo, making it a valuable tool for research on persistent bacterial diseases in plants. Its ability to induce ROS provides insights into mechanisms of plant disease resistance and potential therapeutic strategies. -
Dual-target Anti-inflammatory Peptide
Pegtarazimod is a dual-target anti-inflammatory peptide that regulates both the complement system and neutrophil-associated inflammatory pathways. It demonstrates significant biological activity by reducing reactive oxygen species (ROS) production and lowering neutrophil elastase levels in vivo, thereby mitigating inflammatory responses. Pegtarazimod has shown improved survival rates in multiple in vivo models of acute graft-versus-host disease (aGVHD) and exhibits efficacy against herpes simplex virus type 1 infections by inhibiting the activation of the C1 complex. This reagent is applicable in research focused on aGVHD, acute pulmonary diseases, and skin infections caused by herpes simplex virus type 1. -
PPARγ Inhibitor, heme oxygenase-1 Activator, Nrf2 Activator
PIISVYWK is a potent PPARγ inhibitor that also acts as an activator of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2). This compound effectively modulates the HO-1/Nrf2 signaling pathway, contributing to the reduction of oxidative stress and inflammation, while also exhibiting anti-obesity properties. PIISVYWK is suitable for research applications focused on obesity and related metabolic disorders. -
Keap1/Nrf2/HO-1 Activator
7-Deacetylgedunin is a potent activator of the Keap1/Nrf2/HO-1 signaling pathway. It effectively reduces mortality in mice models induced by lipopolysaccharide (LPS) and demonstrates inhibitory effects on Keap1 expression, leading to the suppression of macrophage proliferation. Additionally, 7-Deacetylgedunin exhibits anti-inflammatory properties both in vitro and in vivo, making it a valuable reagent for research focused on inflammation and oxidative stress. -
Nrf2-ARE Activator
Sesaminol is an oral Nrf2-ARE pathway activator that promotes nuclear translocation of Nrf2 and enhances expression of NQO1, thereby bolstering cellular defense against oxidative stress. This compound has been shown to inhibit 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Additionally, sesaminol demonstrates neuroprotective effects in models of Parkinson's disease induced by Rotenone, making it a valuable tool for research into neuroprotection and oxidative stress response mechanisms. -
Antiinflammatory Agent
Timosaponin E2 is an anti-inflammatory agent that functions by inhibiting the production of reactive oxygen species. This compound demonstrates significant potential in modulating inflammatory responses, making it valuable for research in oxidative stress-related diseases and therapeutic exploration. Its biochemical properties make it a suitable candidate for further investigation in the development of anti-inflammatory therapies. -
Anti-inflammatory Agent
Zaluzanin C is a sesquiterpene lactone that acts as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting mitochondrial reactive oxygen species (mtROS) production and blocking the NF-κB signaling pathway, leading to a reduction in TNF-α levels. Additionally, Zaluzanin C has been shown to prevent the differentiation of 3T3-L1 preadipocytes into mature adipocytes, making it a valuable reagent for research in inflammation and adipogenesis. -
Anti-inflammatory Agent
8-Deoxylactucin is an orally active sesquiterpene lactone that functions as an anti-inflammatory agent by inhibiting LPS-induced nitric oxide production in RAW264.7 macrophages, with an IC50 of 4.35 μM. It exerts its effects primarily by blocking the NF-κB signaling pathway. Additionally, 8-Deoxylactucin has demonstrated hepatoprotective properties in a murine model of acute hepatitis induced by LPS and D-galactosamine. This compound is valuable for research on inflammatory diseases and liver injury mechanisms. -
Anti-inflammatory Agent
Artocarpesin is a flavonoid compound that acts as an anti-inflammatory agent. It exhibits inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the production of nitric oxide (NO), prostaglandin E2 (PGE2), and reactive oxygen species (ROS) through the inhibition of COX-2 and iNOS expression. Additionally, Artocarpesin impedes platelet aggregation via the modulation of cyclic nucleotides and MAPK pathways, making it a valuable reagent for research in cardiovascular diseases and inflammation-related studies. -
NQO1 Inducer
Keap1-Nrf2-IN-10 is a potent inducer of NQO1, mediating the Keap1-Nrf2 signaling pathway. This compound effectively reduces oxidative stress by lowering levels of malondialdehyde (MDA), reactive oxygen species (ROS), and NQO1 in hepatic tissues. Research indicates that Keap1-Nrf2-IN-10 enhances the survival rates of gamma-irradiated mice, making it a valuable tool for studies focused on oxidative damage and cellular protection mechanisms. -
PGE2 Inhibitor
N1-Acetyl-5-methoxykynuramine hydrochloride is a potent inhibitor of prostaglandin E2 (PGE2) production, acting as an active metabolite of melatonin. This compound effectively scavenges reactive oxygen species and suppresses COX-2 expression in RAW 264.7 macrophages in a dose- and time-dependent manner. Additionally, in a mouse model of Parkinson's disease induced by MPTP, it diminishes lipid peroxidation in key brain regions. N1-Acetyl-5-methoxykynuramine hydrochloride is relevant for research focused on metabolic and neurological disorders. -
mTOR Inhibitor
RapaLink-1 is a third-generation bivalent inhibitor targeting the mechanistic target of rapamycin (mTOR). By combining Rapamycin with MLN0128 through an inert linker, RapaLink-1 demonstrates superior efficacy in inhibiting both wild-type and mutant forms of mTOR compared to other inhibitors. This compound effectively crosses the blood-brain barrier, promoting durable mTORC1 inhibition via FKBP12 binding. Additionally, RapaLink-1 exhibits anticancer properties and may play an antithrombotic role in antiphospholipid syndrome by enhancing autophagy. -
'Nrf2 Activator, ROS Inhibitor'
Ezetimibe ketone is a potent Nrf2 activator and reactive oxygen species (ROS) inhibitor. It effectively reduces H2O2-induced ROS production and mitigates apoptosis in renal tubular epithelial cells. This compound has significant implications for research on renal tubular injury and inflammation. -
mTOR Inhibitor/Autophagy Inducer
mTOR inhibitor-8 is a potent inhibitor of the mechanistic target of rapamycin (mTOR), functioning through the interaction with FKBP12. This compound effectively suppresses mTOR activity and induces autophagy in A549 human lung cancer cells. It is a valuable tool for studying mTOR signaling pathways and the role of autophagy in cancer research. -
STING Agonist
2',3'-cGAMP-C2-PPA is a cyclic dinucleotide that acts as a STING (Stimulator of Interferon Genes) agonist. It modulates immune responses by stimulating the production of interferons and other cytokines, making it a valuable tool in cancer immunotherapy research. This compound is particularly useful for studying immune responses in tumor microenvironments and exploring therapeutic strategies for cancer treatment. -
RDC-related Molecule
NOTA-NHS ester is a chelating agent that allows for the creation of radiolabeled compounds, specifically through coupling with T140 to form NOTA-T140. This compound can then be radiolabeled with Al[18F], enabling visualization of tumor uptake that correlates with CXCR4 expression levels. Al[18F]NOTA-T140 is particularly valuable for PET imaging studies of tumors. Additionally, NOTA-NHS ester serves as a versatile tool for fluorescent labeling in various biological applications. -
CXCR4 Targeting Peptide
Pentixafor is a synthetic peptide that targets the CXCR4 receptor, playing a critical role in various cellular processes, including cell migration and signaling. This compound can be labeled with 68Gallium (68Ga), enabling its application in positron emission tomography (PET) imaging for assessing CXCR4 expression in vivo. Additionally, Pentixafor serves as a vital component in the development of Radionuclide-Drug Conjugates (RDCs) for targeted cancer therapies. -
FAP-Targeting Peptide
3BP-3940 is a highly potent and selective peptide inhibitor targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. This reagent exhibits significant potential for tumor imaging when labeled with radionuclides such as Ga-68 and for targeted anticancer therapies using Lu-177. 3BP-3940 selectively accumulates in tumor lesions, making it valuable for the diagnosis and treatment of various solid tumors and conditions related to CAFs. -
FAP Inhibitor
FAPI-mFS is an irreversible inhibitor of fibroblast activation protein (FAP), which targets FAP's enzymatic activity to enhance cancer cell uptake and retention through covalent binding. This compound is particularly useful for cancer imaging and therapy when labeled with radioisotopes such as 68Ga or 177Lu. Additionally, FAPI-mFS serves as a valuable tool in the synthesis and research of radionuclide-drug conjugates (RDCs), facilitating advancements in targeted cancer treatments. -
FAP Inhibitor
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor designed for targeted tumor imaging. This compound effectively binds to FAP, facilitating the visualization of tumors with high detection efficacy. NOTA-FAPI demonstrates superior imaging quality, making it a valuable tool for cancer research and diagnostic applications. -
RDC Peptide
FAP targeting peptide for FXX489 is a polypeptide that specifically targets fibroblast activation protein (FAP). This ligand plays a crucial role in the development of therapeutic agents aimed at modulating FAP-related pathways. It is particularly applicable in cancer research, where FAP is associated with tumor stroma and cancer progression, facilitating targeted delivery of therapeutic compounds. -
Endoradiotherapeutic vector
Anditixafortide is a CXCR4-targeting peptide derivative that functions as an endoradiotherapeutic vector. This reagent is primarily utilized in the synthesis and research of Radionuclide-Drug Conjugates (RDCs), leveraging its ability to selectively target CXCR4-expressing cells. Its application is significant in the field of targeted cancer therapies, facilitating precise delivery of therapeutic radionuclides to tumor sites. -
FAP Targeted Agent
DOTAGA.Glu.(FAPi)2 is a targeted agent that functions as a homodimer specific to fibroblast activation protein (FAP). This compound, which features a central glutamic acid linker connecting FAPi to a chelator, is suitable for radiolabeling with gallium-68, lutetium-177, or terbium-161, making it valuable for PET imaging studies in cancers expressing FAP. Its primary research applications include investigations related to prostate adenocarcinoma and recurrent glioblastoma multiforme, facilitating enhanced imaging and assessment of these malignancies.
