Catalog No.
Product Name
Application
Product Information
Citations
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Nrf2 Activator
Nrf2 activator-4 is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. This compound effectively suppresses reactive oxygen species related to oxidative stress in microglial cells. Additionally, Nrf2 activator-4 demonstrates the ability to recover learning and memory impairments in a scopolamine-induced mouse model, making it a valuable tool for research focused on neuroprotection and cognitive function. -
KEAP1-NRF2 Inhibitor
Keap1-Nrf2-IN-14 is a potent inhibitor of the KEAP1-NRF2 interaction, exhibiting an IC50 value of 75 nM and a Kd of 24 nM for KEAP1. This compound promotes the expression of NRF2 target genes, resulting in enhanced antioxidant and anti-inflammatory responses. Keap1-Nrf2-IN-14 is valuable for investigating oxidative stress-related inflammation and exploring therapeutic strategies targeting the KEAP1-NRF2 signaling pathway. -
Anti-inflammatory compound
U-83836E is an anti-inflammatory compound that exhibits both anti-inflammatory and antioxidant activities. It effectively reduces lung inflammation by inhibiting oxidative stress and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on asthma and lung inflammation in various animal models. -
Anti-inflammatory Agent
Kumujian A (1-Ethoxycarbonyl-β-carboline) is an anti-inflammatory agent that effectively inhibits superoxide anion generation with an IC50 of 4.87 μg/mL and elastase release with an IC50 of 6.29 μg/mL. This compound is valuable for research applications focused on understanding inflammation pathways and developing potential therapeutic strategies for inflammatory diseases. -
Nonsteroidal Anti-inflammatory Agent
Feprazone is a nonsteroidal anti-inflammatory agent that targets cyclooxygenase-2 (COX-2), exhibiting significant analgesic and antipyretic properties. This compound has been shown to mitigate oxidative stress induced by free fatty acids by reducing mitochondrial reactive oxygen species (ROS) production. Additionally, Feprazone inhibits the expression of matrix metalloproteinases MMP-2 and MMP-9, while suppressing adipogenesis and promoting lipolysis in differentiating 3T3-L1 adipocytes. It is valuable for research applications focused on atherosclerosis and obesity. -
Anti-Inflammatory Compound
Dapsone hydroxylamine (DDS-NOH) is an anti-inflammatory compound that primarily targets catalase (CAT) activity. It inhibits CAT activity and reduces the generation of reactive oxygen species, contributing to its anti-inflammatory properties. Dapsone hydroxylamine is utilized in research applications focused on oxidative stress and inflammation modulation. -
Anti-Neuroinflammatory Agent
LZWL02003 is an anti-neuroinflammatory agent that targets neuroinflammatory pathways. It demonstrates protective effects against MPP+-induced neuronal damage and significantly reduces reactive oxygen species (ROS) levels. Additionally, LZWL02003 enhances cognitive functions such as memory, learning, and physical performance in a Rotenone-induced parkinsonism model in rats. This compound is valuable for research into neurodegenerative diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
3′-Oxolutein is an anti-inflammatory agent and a metabolite of dietary lutein. It effectively reduces glutamate-induced reactive oxygen species (ROS) production and pro-inflammatory cytokine secretion in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels while enhancing thiol concentrations. This compound is suitable for research focused on inflammation and oxidative stress responses. -
Anti-inflammatory Agent
Pholidotol C is a stilbene compound that serves as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. It demonstrates significant antioxidant properties, with IC50 values of 28.6 μM for NO production and 21.9 μM for DPPH free radical scavenging. Pholidotol C's mechanisms include the inhibition of NO production in activated macrophages and effective free radical scavenging. This compound is valuable for research in inflammation-related diseases and can be extracted from the dried whole plant of Pholidota chinensis. -
COX-2 Inhibitor
COX-2-IN-65 is a selective inhibitor of cyclooxygenase-2 (COX-2) with a reported IC50 of 10.24 μM. This compound exhibits antibacterial activity against Staphylococcus aureus and Escherichia coli, while also scavenging reactive oxygen species (ROS). COX-2-IN-65 is valuable for research applications focused on bacterial infections and inflammation pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
CD47 Agonist Peptide
Cys-PKHB1 is a CD47 agonist peptide designed to mimic thrombospondin-1. This compound has demonstrated antitumor efficacy by inducing mitochondrial alterations, the generation of reactive oxygen species (ROS), and calcium-dependent cell death in breast cancer cells. Cys-PKHB1 also promotes immune activation through immunogenic cell death, making it a valuable tool for research in cancer immunotherapy and tumor biology. -
ROS Inhibitor
Picrasidine A is a potent reactive oxygen species (ROS) inhibitor derived from the natural product Picrasma quassioides. This compound demonstrates the ability to inhibit UVB-induced ROS generation, making it a valuable tool for research in oxidative stress and related cellular responses. Its applications extend to studies investigating the protective effects against UV radiation and the underlying mechanisms of antioxidative pathways. -
Anti-inflammatory Agent
Dihydromyristicin is a plant-derived flavonoid known for its potent anti-inflammatory effects. It exerts its biological activity by attenuating endotoxic inflammation through the suppression of reactive oxygen species (ROS)-mediated activation of the PI3K/Akt/NF-κB signaling pathways. This compound is valuable in research applications focusing on inflammation-related studies and potential therapeutic interventions. -
ROS Inducer
ROS Inducer 3 (Compound I6) primarily functions as a reactive oxygen species (ROS) inducer. It demonstrates significant in vitro bioactivity with an EC50 of 2.86 μg/mL, showcasing robust protective effects against Pseudomonas syringae pv. actinidiae. As a bactericidal agent, ROS Inducer 3 is relevant for studies focused on managing persistent plant bacterial diseases. -
Anti-Inflammatory Agent
Linocinnamarin is a natural product derived from Fragaria ananassa Duch and functions as an anti-inflammatory agent. It demonstrates significant anti-inflammatory activity by inhibiting the antigen-stimulated increase in intracellular free Ca2+ concentration and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on inflammation pathways and the potential therapeutic effects of natural anti-inflammatory substances. -
ROS Inducer
ROS Inducer 2 (Compound I16) primarily functions as a reactive oxygen species (ROS) inducer, demonstrating significant in vitro bioactivity with an EC50 of 3.43 μg/mL. This compound exhibits potent bactericidal properties against Xanthomonas axonopodis pv. citri in vivo, making it a valuable tool for research on persistent bacterial diseases in plants. Its ability to induce ROS provides insights into mechanisms of plant disease resistance and potential therapeutic strategies. -
Dual-target Anti-inflammatory Peptide
Pegtarazimod is a dual-target anti-inflammatory peptide that regulates both the complement system and neutrophil-associated inflammatory pathways. It demonstrates significant biological activity by reducing reactive oxygen species (ROS) production and lowering neutrophil elastase levels in vivo, thereby mitigating inflammatory responses. Pegtarazimod has shown improved survival rates in multiple in vivo models of acute graft-versus-host disease (aGVHD) and exhibits efficacy against herpes simplex virus type 1 infections by inhibiting the activation of the C1 complex. This reagent is applicable in research focused on aGVHD, acute pulmonary diseases, and skin infections caused by herpes simplex virus type 1. -
PPARγ Inhibitor, heme oxygenase-1 Activator, Nrf2 Activator
PIISVYWK is a potent PPARγ inhibitor that also acts as an activator of heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2). This compound effectively modulates the HO-1/Nrf2 signaling pathway, contributing to the reduction of oxidative stress and inflammation, while also exhibiting anti-obesity properties. PIISVYWK is suitable for research applications focused on obesity and related metabolic disorders. -
Keap1/Nrf2/HO-1 Activator
7-Deacetylgedunin is a potent activator of the Keap1/Nrf2/HO-1 signaling pathway. It effectively reduces mortality in mice models induced by lipopolysaccharide (LPS) and demonstrates inhibitory effects on Keap1 expression, leading to the suppression of macrophage proliferation. Additionally, 7-Deacetylgedunin exhibits anti-inflammatory properties both in vitro and in vivo, making it a valuable reagent for research focused on inflammation and oxidative stress. -
Nrf2-ARE Activator
Sesaminol is an oral Nrf2-ARE pathway activator that promotes nuclear translocation of Nrf2 and enhances expression of NQO1, thereby bolstering cellular defense against oxidative stress. This compound has been shown to inhibit 6-OHDA-induced ROS production and apoptosis in SH-SY5Y cells. Additionally, sesaminol demonstrates neuroprotective effects in models of Parkinson's disease induced by Rotenone, making it a valuable tool for research into neuroprotection and oxidative stress response mechanisms. -
Antiinflammatory Agent
Timosaponin E2 is an anti-inflammatory agent that functions by inhibiting the production of reactive oxygen species. This compound demonstrates significant potential in modulating inflammatory responses, making it valuable for research in oxidative stress-related diseases and therapeutic exploration. Its biochemical properties make it a suitable candidate for further investigation in the development of anti-inflammatory therapies. -
Anti-inflammatory Agent
Zaluzanin C is a sesquiterpene lactone that acts as an anti-inflammatory agent. It exhibits significant anti-inflammatory activity by inhibiting mitochondrial reactive oxygen species (mtROS) production and blocking the NF-κB signaling pathway, leading to a reduction in TNF-α levels. Additionally, Zaluzanin C has been shown to prevent the differentiation of 3T3-L1 preadipocytes into mature adipocytes, making it a valuable reagent for research in inflammation and adipogenesis. -
Anti-inflammatory Agent
8-Deoxylactucin is an orally active sesquiterpene lactone that functions as an anti-inflammatory agent by inhibiting LPS-induced nitric oxide production in RAW264.7 macrophages, with an IC50 of 4.35 μM. It exerts its effects primarily by blocking the NF-κB signaling pathway. Additionally, 8-Deoxylactucin has demonstrated hepatoprotective properties in a murine model of acute hepatitis induced by LPS and D-galactosamine. This compound is valuable for research on inflammatory diseases and liver injury mechanisms. -
Anti-inflammatory Agent
Artocarpesin is a flavonoid compound that acts as an anti-inflammatory agent. It exhibits inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) by downregulating the production of nitric oxide (NO), prostaglandin E2 (PGE2), and reactive oxygen species (ROS) through the inhibition of COX-2 and iNOS expression. Additionally, Artocarpesin impedes platelet aggregation via the modulation of cyclic nucleotides and MAPK pathways, making it a valuable reagent for research in cardiovascular diseases and inflammation-related studies. -
NQO1 Inducer
Keap1-Nrf2-IN-10 is a potent inducer of NQO1, mediating the Keap1-Nrf2 signaling pathway. This compound effectively reduces oxidative stress by lowering levels of malondialdehyde (MDA), reactive oxygen species (ROS), and NQO1 in hepatic tissues. Research indicates that Keap1-Nrf2-IN-10 enhances the survival rates of gamma-irradiated mice, making it a valuable tool for studies focused on oxidative damage and cellular protection mechanisms. -
PGE2 Inhibitor
N1-Acetyl-5-methoxykynuramine hydrochloride is a potent inhibitor of prostaglandin E2 (PGE2) production, acting as an active metabolite of melatonin. This compound effectively scavenges reactive oxygen species and suppresses COX-2 expression in RAW 264.7 macrophages in a dose- and time-dependent manner. Additionally, in a mouse model of Parkinson's disease induced by MPTP, it diminishes lipid peroxidation in key brain regions. N1-Acetyl-5-methoxykynuramine hydrochloride is relevant for research focused on metabolic and neurological disorders. -
mTOR Inhibitor
RapaLink-1 is a third-generation bivalent inhibitor targeting the mechanistic target of rapamycin (mTOR). By combining Rapamycin with MLN0128 through an inert linker, RapaLink-1 demonstrates superior efficacy in inhibiting both wild-type and mutant forms of mTOR compared to other inhibitors. This compound effectively crosses the blood-brain barrier, promoting durable mTORC1 inhibition via FKBP12 binding. Additionally, RapaLink-1 exhibits anticancer properties and may play an antithrombotic role in antiphospholipid syndrome by enhancing autophagy. -
'Nrf2 Activator, ROS Inhibitor'
Ezetimibe ketone is a potent Nrf2 activator and reactive oxygen species (ROS) inhibitor. It effectively reduces H2O2-induced ROS production and mitigates apoptosis in renal tubular epithelial cells. This compound has significant implications for research on renal tubular injury and inflammation. -
mTOR Inhibitor/Autophagy Inducer
mTOR inhibitor-8 is a potent inhibitor of the mechanistic target of rapamycin (mTOR), functioning through the interaction with FKBP12. This compound effectively suppresses mTOR activity and induces autophagy in A549 human lung cancer cells. It is a valuable tool for studying mTOR signaling pathways and the role of autophagy in cancer research. -
STING Agonist
2',3'-cGAMP-C2-PPA is a cyclic dinucleotide that acts as a STING (Stimulator of Interferon Genes) agonist. It modulates immune responses by stimulating the production of interferons and other cytokines, making it a valuable tool in cancer immunotherapy research. This compound is particularly useful for studying immune responses in tumor microenvironments and exploring therapeutic strategies for cancer treatment. -
RDC-related Molecule
NOTA-NHS ester is a chelating agent that allows for the creation of radiolabeled compounds, specifically through coupling with T140 to form NOTA-T140. This compound can then be radiolabeled with Al[18F], enabling visualization of tumor uptake that correlates with CXCR4 expression levels. Al[18F]NOTA-T140 is particularly valuable for PET imaging studies of tumors. Additionally, NOTA-NHS ester serves as a versatile tool for fluorescent labeling in various biological applications. -
CXCR4 Targeting Peptide
Pentixafor is a synthetic peptide that targets the CXCR4 receptor, playing a critical role in various cellular processes, including cell migration and signaling. This compound can be labeled with 68Gallium (68Ga), enabling its application in positron emission tomography (PET) imaging for assessing CXCR4 expression in vivo. Additionally, Pentixafor serves as a vital component in the development of Radionuclide-Drug Conjugates (RDCs) for targeted cancer therapies. -
FAP-Targeting Peptide
3BP-3940 is a highly potent and selective peptide inhibitor targeting fibroblast activation protein (FAP) in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. This reagent exhibits significant potential for tumor imaging when labeled with radionuclides such as Ga-68 and for targeted anticancer therapies using Lu-177. 3BP-3940 selectively accumulates in tumor lesions, making it valuable for the diagnosis and treatment of various solid tumors and conditions related to CAFs. -
FAP Inhibitor
FAPI-mFS is an irreversible inhibitor of fibroblast activation protein (FAP), which targets FAP's enzymatic activity to enhance cancer cell uptake and retention through covalent binding. This compound is particularly useful for cancer imaging and therapy when labeled with radioisotopes such as 68Ga or 177Lu. Additionally, FAPI-mFS serves as a valuable tool in the synthesis and research of radionuclide-drug conjugates (RDCs), facilitating advancements in targeted cancer treatments. -
FAP Inhibitor
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor designed for targeted tumor imaging. This compound effectively binds to FAP, facilitating the visualization of tumors with high detection efficacy. NOTA-FAPI demonstrates superior imaging quality, making it a valuable tool for cancer research and diagnostic applications. -
RDC Peptide
FAP targeting peptide for FXX489 is a polypeptide that specifically targets fibroblast activation protein (FAP). This ligand plays a crucial role in the development of therapeutic agents aimed at modulating FAP-related pathways. It is particularly applicable in cancer research, where FAP is associated with tumor stroma and cancer progression, facilitating targeted delivery of therapeutic compounds. -
Endoradiotherapeutic vector
Anditixafortide is a CXCR4-targeting peptide derivative that functions as an endoradiotherapeutic vector. This reagent is primarily utilized in the synthesis and research of Radionuclide-Drug Conjugates (RDCs), leveraging its ability to selectively target CXCR4-expressing cells. Its application is significant in the field of targeted cancer therapies, facilitating precise delivery of therapeutic radionuclides to tumor sites. -
FAP Targeted Agent
DOTAGA.Glu.(FAPi)2 is a targeted agent that functions as a homodimer specific to fibroblast activation protein (FAP). This compound, which features a central glutamic acid linker connecting FAPi to a chelator, is suitable for radiolabeling with gallium-68, lutetium-177, or terbium-161, making it valuable for PET imaging studies in cancers expressing FAP. Its primary research applications include investigations related to prostate adenocarcinoma and recurrent glioblastoma multiforme, facilitating enhanced imaging and assessment of these malignancies. -
Liposome
DOTA Conjugated JM#21 derivative 7 is a CXCR4-targeting peptide conjugated with DOTA, designed for the synthesis of radioligands. When radiolabeled as 177Lu-DOTA, it demonstrates superior targeting of CXCR4-expressing tumors while exhibiting minimal uptake in non-targeted organs, except for the kidneys. This compound is ideal for research applications involving Radionuclide-Drug Conjugates (RDCs), facilitating advancements in targeted radiotherapy. -
Peptide-PEG2 Conjugate of Unlabeled FXX489
FAP targeting peptide-PEG2 conjugate is a peptide-PEG2 linker conjugate of Unlabeled FXX489, a ligand specifically targeting fibroblast activation protein (FAP). This conjugate facilitates targeted delivery and enhances bioavailability in therapeutic applications. It is primarily employed in research focusing on FAP-related diseases, offering valuable insights into cancer progression and tissue remodeling. -
anti-CD22-Calecheamicin Conjugate
Inotuzumab ozogamicin is an antibody-drug conjugate targeting CD22, composed of a humanized anti-CD22 antibody linked to the cytotoxic agent Calicheamicin. This compound exhibits potent efficacy against CD22-positive B-cell non-Hodgkin’s lymphoma and is being investigated for its potential in treating acute lymphoblastic leukemia. Researchers can utilize Inotuzumab ozogamicin to explore therapeutic strategies for CD22-expressing malignancies. -
Anti-inflammatory Agent
3,5,6,7,8,3',4'-Heptemthoxyflavone is a flavonoid with potent anti-inflammatory properties, functioning as a CREB activator. This compound exhibits anti-tumor and neuroprotective activities by inhibiting collagenase activity and enhancing type I procollagen synthesis in human dermal fibroblast neoblast (HDFn) cells. Additionally, it promotes the expression of brain-derived neurotrophic factor (BDNF) via the cAMP/ERK/CREB signaling pathway and decreases phosphodiesterase activity in C6 glioma cells, making it a valuable tool for research in inflammation and neurobiology. -
Autotaxin Inhibitor
MHC02181 is a potent inhibitor of Autotaxin (ATX), demonstrating an IC50 value of 9.41 μM. By inhibiting ATX, it plays a critical role in modulating lysophosphatidic acid (LPA) production, which is involved in various physiological and pathological processes. This reagent is valuable for research applications focused on cancer progression, fibrosis, and other ATX-mediated diseases. -
Autotaxin Inhibitor
MHC00188 is an allosteric inhibitor of Autotaxin (ATX) with an IC50 of 2.53 μM. This compound modulates ATX activity, which plays a critical role in the production of lysophosphatidic acid (LPA), a signaling lipid involved in various physiological processes. MHC00188 is useful for research into cancer biology, inflammation, and other conditions related to aberrant LPA signaling. -
COX Inhibitor
Aspirin DL-lysine is a lysine-conjugated derivative of aspirin that functions primarily as a cyclooxygenase (COX) inhibitor. This compound effectively inhibits the synthesis of thromboxane A2 (TXA2) in platelets, leading to a reduction in platelet activation and aggregation. Aspirin DL-lysine is valuable for research applications focused on thrombin generation, particularly in clinical studies involving unstable angina pectoris. -
PI3K/Akt Inhibitor, MAPK Inhibitor, NF-κB Inhibitor, Nrf2/ARE Activator
JRN73958 is a potent inhibitor of the PI3K/Akt, MAPK, and NF-κB signaling pathways. This compound effectively reduces LPS/IFNγ-induced activation of these pathways, making it a valuable tool for investigating their roles in cancer biology, particularly in leukemia research. Additionally, JRN73958 acts as an Nrf2/ARE activator, further expanding its utility in studies related to oxidative stress and cell survival mechanisms. -
Anti-Inflammatory Agent
Anti-inflammatory agent 33 is a potent inhibitor of the p38α MAPK pathway. It effectively suppresses nitric oxide (NO) production and reduces the expression of iNOS, COX-2, and phosphorylated p38α and MK2 in response to lipopolysaccharide (LPS) stimulation. This compound demonstrates significant anti-inflammatory activity, making it valuable for research into inflammatory processes and potential therapeutic applications. -
FKBP12 Inhibitor
WAY-380153 is an FKBP12 inhibitor that demonstrates moderate binding affinity for FKBP12, with a KD of 19 μM measured via isothermal titration calorimetry and 15 μM via nuclear magnetic resonance. This compound is relevant for research applications involving neurotrophy and neuroprotection, serving as a valuable tool for investigating conditions related to neuronal health and function. -
FKBP51 Degrader, VHL Binder
SelDeg51 is a selective PROTAC degrader targeting FKBP51 with a Kd value of 18 nM and a maximum degradation efficacy (Dmax) of 90%. It facilitates the proteasomal degradation of FKBP51 through the formation of a ternary complex with FKBP51 and VHL, effectively reactivating glucocorticoid receptor signaling. SelDeg51 is particularly relevant for research in stress-related mental disorders, chronic pain, and obesity.
