FAP6-19 is a radioligand targeting fibroblast activation protein (FAP) with a Kd of 18.2 nM. This compound selectively delivers therapeutic radioactive isotopes, such as 177Lu, directly to tumors that overexpress FAP in the microenvironment, enabling targeted destruction of malignant cells while preserving healthy tissues. FAP6-19 demonstrates high total cellular uptake and excellent intracellular retention in HT1080 cells. When labeled with 111In, it achieves favorable tumor/kidney and tumor/liver dose ratios in mouse models with 4T1 tumors. This reagent is valuable for research involving solid tumors that express FAP.
FAP6-19 is a radioligand targeting fibroblast activation protein (FAP) with a Kd of 18.2 nM. This compound selectively delivers therapeutic radioactive isotopes, such as 177Lu, directly to tumors that overexpress FAP in the microenvironment, enabling targeted destruction of malignant cells while preserving healthy tissues. FAP6-19 demonstrates high total cellular uptake and excellent intracellular retention in HT1080 cells. When labeled with 111In, it achieves favorable tumor/kidney and tumor/liver dose ratios in mouse models with 4T1 tumors. This reagent is valuable for research involving solid tumors that express FAP.
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