FEN1-IN-7 is a selective inhibitor of Flap endonuclease-1 (FEN1), with an IC50 of 18 nM, crucial for DNA repair in mammalian cells. In addition, it exhibits activity against xeroderma pigmentosum G (XPG) with an IC50 of 3.04 μM. FEN1-IN-7 enhances the sensitivity of cancer cells to DNA alkylating and methylating agents, making it a valuable tool for research in cancer therapy and DNA damage response mechanisms.
FEN1-IN-7 is a selective inhibitor of Flap endonuclease-1 (FEN1), with an IC50 of 18 nM, crucial for DNA repair in mammalian cells. In addition, it exhibits activity against xeroderma pigmentosum G (XPG) with an IC50 of 3.04 μM. FEN1-IN-7 enhances the sensitivity of cancer cells to DNA alkylating and methylating agents, making it a valuable tool for research in cancer therapy and DNA damage response mechanisms.
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