ALR-27 is a selective antagonist of the 5-lipoxygenase activating protein (FLAP), exhibiting significant anti-inflammatory properties. This compound effectively inhibits the formation of 5-LOX products by more than 80% in pro-inflammatory M1 macrophage-derived macrophages (M1-MDM), without directly inhibiting 5-LOX activity. Additionally, ALR-27 reduces the production of prostaglandins and leukotrienes in neutrophils while promoting the synthesis of specialized pro-resolving mediators in distinct human macrophage phenotypes. These characteristics make ALR-27 valuable for research in inflammation and immune response modulation.
ALR-27 is a selective antagonist of the 5-lipoxygenase activating protein (FLAP), exhibiting significant anti-inflammatory properties. This compound effectively inhibits the formation of 5-LOX products by more than 80% in pro-inflammatory M1 macrophage-derived macrophages (M1-MDM), without directly inhibiting 5-LOX activity. Additionally, ALR-27 reduces the production of prostaglandins and leukotrienes in neutrophils while promoting the synthesis of specialized pro-resolving mediators in distinct human macrophage phenotypes. These characteristics make ALR-27 valuable for research in inflammation and immune response modulation.
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