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DB21, Galectin-1 Antagonist

Catalog No.: A64683
Galectin-1 Inhibitor
DB21 is a Galectin-1 antagonist that functions as an allosteric inhibitor of galectin-1 binding to cell surface glycans. This dibenzofuran-conjugated peptidomimetic demonstrates significant inhibition of angiogenesis and tumor growth in models of melanoma, lung adenocarcinoma, and ovarian cancer. Its ability to disrupt galectin-1 interactions positions DB21 as a valuable tool for cancer research and therapeutic development.
DB21, Galectin-1 Antagonist 1623027-80-4 Galectin-1 Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDB21 is a Galectin-1 antagonist that functions as an allosteric inhibitor of galectin-1 binding to cell surface glycans. This dibenzofuran-conjugated peptidomimetic demonstrates significant inhibition of angiogenesis and tumor growth in models of melanoma, lung adenocarcinoma, and ovarian cancer. Its ability to disrupt galectin-1 interactions positions DB21 as a valuable tool for cancer research and therapeutic development.
Product Information
Catalog NumA64683
FormulaC83H136N18O19
Molecular Weight1690.08
CAS Number1623027-80-4
SequenceSer-Val-Gln-{Nva}-Lys-Leu-{DBF}-Ile-Ile-Val-Lys-Leu-Asn-Ala
Sequence shorteningSVQ-{Nva}-KL-{DBF}-IIVKLNA
SMILESO=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(O)=O)=O)=O)=O)=O)=O)[C@H]([C@@H](C)CC)NC(CCC1=CC=CC2=C1OC3=C2C=CC=C3CCNC([C@H](CC(C)C)NC([C@@H](NC([C@@H](CCC)NC([C@H](CCC(N)=O)NC([C@H](C(C)C)NC([C@H](CO)N)=O)=O)=O)=O)CCCCN)=O)=O)=O
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Immunology & Inflammation > Galectin