Catalog No.
Product Name
Application
Product Information
Citations
-
iNOS Inhibitor
Asperuloside is an iridoid compound derived from Hedyotis diffusa, primarily known for its role as an inducible nitric oxide synthase (iNOS) inhibitor. This compound exhibits notable anti-inflammatory properties by suppressing the NF-κB and MAPK signaling pathways. Asperuloside is valuable in studying inflammatory processes and developing therapeutic strategies for related diseases. -
Nrf2 Activator
RA839 is a selective activator of the Nrf2/ARE pathway, functioning as a non-covalent small molecule binder of Keap1 with a Kd of approximately 6 μM. This compound inhibits the expression of inducible nitric oxide synthase and the subsequent release of nitric oxide. RA839 demonstrates significant anti-rotaviral and anti-inflammatory properties, making it a valuable tool for research into oxidative stress, viral infections, and inflammation-related pathways. -
Nitrogen Donor
L-Arginine L-glutamate serves as a critical nitrogen donor for the synthesis of nitric oxide, a key signaling molecule in various biological processes. This compound is valuable in studying gastrointestinal hypofunction or dysfunction, including conditions such as functional dyspepsia. Its role in modulating nitric oxide levels makes it significant for research into cardiovascular health and metabolic regulation. -
NO Donor
MAHMA NONOate is a nitric oxide (NO) donor that facilitates the release of NO in biological systems. It demonstrates significant inhibitory effects on platelet aggregation induced by collagen or ADP, making it valuable for research related to cardiovascular physiology and thrombosis. This compound is useful for studying the mechanisms of NO signaling in various biological contexts. -
CaV1.2 Channel Inhibitor
Demethylsuberosin, a coumarin derivative isolated from Angelica gigas Nakai, primarily targets the L-type CaV1.2 channel as an inhibitor. This compound demonstrates significant antihypertensive effects, in addition to possessing antioxidant and anti-inflammatory properties. Notably, Demethylsuberosin offers neuroprotective effects against glutamate-induced cytotoxicity in primary cultured rat cortical cells, making it a valuable reagent for research in cardiovascular and neurological studies. -
Cyanide Antidote
Hydroxocobalamin acetate is a derivative of vitamin B12 that acts as an effective cyanide antidote. It works by binding to nitric oxide and facilitating the detoxification of cyanide and sodium sulfide. Additionally, hydroxocobalamin acetate has been shown to mitigate hypotension. This compound is utilized in research pertaining to vitamin B12 deficiency disorders, including pernicious anemia. -
iNOS Inhibitor
GW274150 phosphate is a selective, orally active inhibitor of inducible nitric oxide synthase (iNOS), demonstrating potent inhibition with an IC50 of 2.19 μM and a Kd of 40 nM in human iNOS, as well as an ED50 of 1.15 μM in rat iNOS. This compound exhibits reduced potency against endothelial and neuronal NOS isoforms. GW274150 phosphate has been shown to provide protective effects in models of acute lung injury and inflammation, making it a valuable tool for researchers studying inflammatory responses and related pathways. -
Anti-inflammatory Drug
Regaloside A is a phenylpropanoid with notable anti-inflammatory properties. It demonstrates significant DPPH radical scavenging activity, with a measured efficacy of 58.0% at a concentration of 160 ppm. This compound is useful in investigating anti-inflammatory mechanisms and for potential therapeutic applications in inflammatory diseases. -
Anti-inflammatory Agent
Ciwujianoside C3 is an orally active compound that functions as an anti-inflammatory agent. Isolated from the leaves of Acanthopanax henryi Harms, this reagent demonstrates significant anti-inflammatory properties while also enhancing object recognition memory. Its biological activity supports research in neuroprotection and cognitive enhancement studies. -
NO Synthase Inhibtior
NG-nitro-L-arginine is a potent nitric oxide synthase (NOS) inhibitor, demonstrating inhibitory constants (Kis) of 0.61 μM for neuronal NOS (nNOS), 4.28 μM for inducible NOS (iNOS), and 0.72 μM for endothelial NOS (eNOS). This compound effectively inhibits the formation and release of endothelium-derived relaxing factor (EDRF), making it a valuable tool in cardiovascular research. NG-nitro-L-arginine has been shown to reduce portal-systemic shunting in portal-hypertensive rat models and is associated with increased blood pressure, thereby serving as a key reagent for studies investigating vascular function and regulation. -
NO Synthase Inhibitor
Kuwanon A is a flavone derivative that serves as an inhibitor of nitric oxide synthase. It effectively reduces nitric oxide production with an IC50 of 10.5 μM. This compound is relevant for research applications investigating vascular function, inflammatory processes, and the pathophysiology of various diseases linked to nitric oxide signaling. -
NOS Inhibitor
S-MTC dihydrochloride is a selective inhibitor of type I nitric oxide synthase (NOS). It effectively reduces nitric oxide production, making it a valuable tool for studies investigating the role of NOS in various physiological and pathological processes. This compound is commonly utilized in research applications related to cardiovascular health, neurobiology, and inflammation. -
nNOS Inhibitor
Nω-Propyl-L-arginine is a highly selective and potent competitive inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a Ki value of 57 nM. With a 149-fold selectivity for nNOS over endothelial nitric oxide synthase (eNOS), this compound is invaluable for studying nNOS-related pathways and neurobiology. Its use is pertinent in elucidating the role of nNOS in various physiological and pathological processes, making it a crucial reagent for research applications in neuroscience and pharmacology. -
nitric oxide synthase Inhibitor
Aminopicoline is a potent and non-selective inhibitor of nitric oxide synthase (NOS) isoenzymes, including iNOS, nNOS, and eNOS. By competing with arginine at the substrate-binding site, it effectively reduces cellular nitric oxide production and inhibits the elevation of plasma nitrate levels, which can influence mean arterial pressure. This compound serves as a valuable tool in research focused on diseases related to septic shock, joint and intestinal inflammation, as well as central nervous system (CNS) inflammation. -
NO Synthase Antagonist
L-NMMA (N-methyl-L-arginine) is a competitive antagonist of L-arginine that effectively inhibits the production of nitric oxide (NO) by targeting nitric oxide synthase. This compound is employed in various experimental studies to investigate the physiological and pathological roles of NO and its signaling pathways. Its application extends to cardiovascular research, neurobiology, and studies involving vascular function. -
NOS3 Inhibitors
Kihadanin A is a limonoid that functions as an inhibitor of nitric oxide synthase 3 (NOS3). Isolated from the methanol extract of Dictamnus dasycarpus root bark, Kihadanin A demonstrates potential therapeutic applications in the study of hyperuricemia (HUA). This compound can be utilized in research aimed at understanding the biochemical pathways related to nitric oxide production and its implications in various physiological conditions. -
NOS Inhibitor
nNOS-IN-1 is a selective inhibitor of nitric oxide synthases (NOS), demonstrating potent inhibitory activity against neuronal, inducible, and endothelial NOS with IC50 values of 2.5, 5.7, and 13 μM, respectively. This compound serves as a valuable tool for elucidating the roles of nitric oxide in various biological processes and has potential applications in neurobiology and cardiovascular research. By selectively targeting NOS, nNOS-IN-1 can aid in the investigation of pathological conditions associated with dysregulated nitric oxide signaling. -
nNOS Inhibitor
Nω-Propyl-L-arginine hydrochloride is a selective inhibitor of neuronal nitric oxide synthase (nNOS), exhibiting a competitive inhibition profile with a Ki value of 57 nM. This compound offers significant selectivity, displaying a 149-fold preference for nNOS over endothelial nitric oxide synthase (eNOS). Nω-Propyl-L-arginine hydrochloride is primarily utilized in research applications focused on the modulation of nitric oxide pathways and the study of nNOS-related physiological and pathological processes. -
NO Synthase Inhibitor
2-Iminobiotin hydrobromide is a reversible inhibitor of nitric oxide synthase (NOS), specifically exhibiting Kis of 21.8 μM for murine inducible NOS (iNOS) and 37.5 μM for rat neuronal NOS (n-cNOS). This compound has demonstrated potential neuroprotective effects, providing protection to human neuronal cells against hypoxia-induced cell damage. It is valuable for research in neurobiology and the study of nitric oxide signaling pathways. -
iNOS Inhibitor
AR-C102222 hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS) with a competitive mechanism of action. Demonstrating an IC50 of 37 nM, it exhibits notable antinociceptive and anti-inflammatory properties. This compound is valuable for research into pain modulation and inflammatory diseases, providing insights into the role of nitric oxide in these biological processes. -
Anti-inflammatory Drug
Ikarisoside A is a natural flavonol glycoside known for its anti-inflammatory properties. This compound exhibits significant activity in reducing inflammation, making it valuable for research focused on inflammatory diseases and related therapeutic applications. Its mechanism of action may involve the modulation of inflammatory pathways, providing insights for the development of new anti-inflammatory treatments. -
iNOS Inhibitor
BBS-4 is a highly potent and selective inhibitor of inducible nitric oxide synthase (iNOS, NOS2) dimerization, demonstrating an IC50 of 0.49 nM. This compound is primarily utilized in research focused on cardiovascular dysfunction, notably offering protective effects in murine models of sepsis. Its selective inhibition of iNOS makes BBS-4 a valuable tool for investigating nitric oxide-related pathologies and potential therapeutic interventions. -
Substrate for NO Synthase
L-Hydroxy arginine dihydrochloride is a substrate for nitric oxide synthase (NOS), playing a crucial role in the production of nitric oxide from L-arginine. This compound is utilized in biochemical research to investigate the enzymatic pathways of NO synthesis and its physiological implications. Its applications extend to studies exploring vascular function, signal transduction, and the impact of nitric oxide in various biological systems. -
nNOS Inhibitor
NOS1-IN-1 is a selective and cell-permeable inhibitor of neuronal nitric oxide synthase (nNOS), displaying a Ki of 120 nM. This compound demonstrates significant selectivity, with a 2617-fold preference over endothelial nitric oxide synthase (eNOS) and a 325-fold selectivity over inducible nitric oxide synthase (iNOS), evidenced by Ki values of 39 μM and 325 μM, respectively. NOS1-IN-1 is valuable for research on neurological disorders, including cerebral palsy, by enabling the exploration of nNOS-related pathways in disease mechanisms. -
NO Synthase Inhibitor
NOS-IN-1 is a potent and orally bioavailable inhibitor of nitric oxide synthase (NOS) isoforms, demonstrating inhibitory constants (IC50) of 0.1 μM for human inducible NOS (hiNOS), 1.1 μM for endothelial NOS (heNOS), and 0.2 μM for neuronal NOS (hnNOS). This compound is valuable for studying nitric oxide signaling pathways and exploring therapeutic options in diseases associated with dysregulated nitric oxide levels, such as cardiovascular disorders and neurodegenerative diseases. Its selective inhibition of NOS isoforms can aid in elucidating the specific roles of nitric oxide in various biological processes. -
NOS Inhibitor
TRIM is a potent nitric oxide synthase (NOS) inhibitor, selectively targeting neuronal nitric oxide synthase (nNOS) in mouse cerebellar samples and inducible nitric oxide synthase (iNOS) in rat lung tissues, with IC50 values of 28.2 µM and 27.0 µM, respectively. This compound exhibits significant antidepressant and anxiolytic-like properties, making it valuable for research into depression and anxiety disorders. TRIM serves as an important tool for investigations into NOS-related pathways and their implications in neuropsychiatric conditions. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-1 is a potent inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS), exhibiting a binding affinity (KD) of 4.4 nM. This cyclic peptide demonstrates resistance to proteolytic degradation by pepsin, trypsin, and α-chymotrypsin, ensuring stability in biological environments. Additionally, it maintains stability in human plasma and oxidative conditions, making it a valuable tool for studying iNOS-related pathways in inflammation and other biological processes. -
iNOS/Nf-Κb Inhibitor
Hymenoxin is a dual inhibitor of inducible nitric oxide synthase (iNOS) and nuclear factor kappa B (NF-κB), exhibiting IC50 values of 42.7 μM and 85.5 μM, respectively. This compound demonstrates the capacity to reduce oxidative stress by 16% at a concentration of 125 μg/mL. Hymenoxin is primarily utilized in research focused on inflammatory responses and related signaling pathways. Its inhibitory effects on key regulators make it valuable for studies investigating the roles of iNOS and NF-κB in various disease models. -
NOS Inhibitor
Vinyl-L-NIO hydrochloride is a selective inhibitor of nitric oxide synthase (NOS), effectively reducing nitric oxide production. By targeting the NOS enzyme, this compound serves as a valuable tool for investigating the role of nitric oxide in various biological processes. Its application extends to studies related to cardiovascular function, neurobiology, and inflammation research. -
NOS1Inhibitor
ARL 17477 is a dual inhibitor targeting neuronal nitric oxide synthase (NOS1) and the autophagy-lysosomal system. This compound exhibits significant anticancer activity and effectively inhibits tumor growth, particularly in KRAS-mutated cancers. Its potential applications include studies on cancer progression and therapeutic resistance, making it a valuable tool in cancer research. -
Anti-inflammatory Agent
Damnacanthol is a natural product derived from Damnacanthus major, acting primarily as an anti-inflammatory agent. It exhibits potent anti-15-lipoxygenase activity and effectively inhibits nitric oxide production in LPS-activated RAW 264.7 macrophage cells. This compound is suited for research applications focused on inflammation and related pathways. -
NO Synthase Inhibitor
Asymmetric dimethylarginine dihydrochloride is a potent inhibitor of nitric oxide synthase (NOS). By decreasing nitric oxide (NO) production, it plays a significant role in the study of endothelial dysfunction and related cardiovascular diseases. This compound is instrumental in research focused on elucidating the pathways involved in vascular health and hypertension. -
NOS Inhibitor
1,4-PBIT dihydrobromide is a potent inhibitor of nitric oxide synthases (NOS), demonstrating Ki values of 7.6 nM for inducible NOS (iNOS), 360 nM for endothelial NOS (eNOS), and 16 nM for neuronal NOS (nNOS). This compound serves as a valuable tool for investigating nitric oxide signaling pathways and assessing the role of NOS in various biological contexts. It is applicable in studies related to inflammation, neurobiology, and cardiovascular research. -
iNOS Inhibitor
AE-ITU dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS). This compound has been shown to attenuate liver dysfunction induced by endotoxaemia in rat models, demonstrating its potential in studies related to inflammatory responses and liver pathology. AE-ITU dihydrobromide is valuable for researchers investigating the role of nitric oxide in various biological processes and therapeutic interventions. -
Cytotoxin
Banoxantrone, a hypoxia-selective cytotoxin, functions as a potent inhibitor of topoisomerase II after undergoing reduction to AQ4. It selectively targets and induces cell death in hypoxic environments through an iNOS-dependent mechanism. Additionally, Banoxantrone demonstrates significant cytotoxicity and synergizes with radiation to enhance its therapeutic effects, making it useful in cancer research focused on hypoxic tumors. -
eNOS Enhancer
AVE-9488 is an eNOS enhancer that promotes the upregulation of endothelial nitric oxide synthase (eNOS) expression, leading to increased nitric oxide (NO) production. This compound has demonstrated protective effects on the heart against ischemia-reperfusion injury by reducing myocardial damage and lowering reactive oxygen species levels. AVE-9488 is valuable for research focused on cardiovascular protection and the modulation of nitric oxide signaling pathways. -
NO Synthase Inhibitor
Curvularin is a potent inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a half-maximal inhibitory concentration (IC50) of 9.5 µM. Isolated from the fungus Curvularia lunata, this mycotoxin is utilized in research to explore its effects on nitric oxide production in inflammatory responses. Curvularin's unique properties make it a valuable tool for investigating various biological processes and therapeutic applications related to iNOS inhibition. -
Anti-inflammatory Agent
Cauloside D is a triterpene glycoside derived from Caulophyllum robustum Max, known for its potent anti-inflammatory properties. It modulates inflammatory responses by inhibiting the expression of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines. This compound serves as a valuable tool for research into inflammatory diseases and therapeutic interventions targeting inflammatory pathways. -
Anti-inflammatory Agent
5,7,8-Trimethoxyflavone is a flavonoid compound known for its anti-inflammatory properties. Isolated from Andrographis echioides, this compound effectively inhibits nitric oxide (NO) production with an IC50 of 39.1 μM. It is utilized in research applications focused on understanding the mechanisms of inflammation and exploring potential therapeutic avenues for inflammatory diseases. -
ZLc-002 S-enantiomer
(S)-ZLc002 is the S-enantiomer of ZLc-002, a selective inhibitor of neuronal nitric oxide synthase (nNOS) and its interaction with Capon. This compound demonstrates significant anti-inflammatory effects by suppressing inflammatory nociception and alleviating chemotherapy-induced neuropathic pain. It serves as an important tool for researchers studying pain mechanisms and potential therapeutic interventions in neuropathic conditions. -
iNOS Inhibitor
L-NIL hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrated to have an IC50 of 3.3 μM in murine models. By inhibiting iNOS, L-NIL hydrochloride effectively reduces the production of nitric oxide, a key mediator in various inflammatory processes. This compound is utilized in research focused on inflammation, neurodegeneration, and associated pathologies where modulation of nitric oxide levels is critical. -
Anti-Inflammatory Agent
Amaroswerin is a bioactive secoiridoid glucoside derived from Swertia mussotii, acting primarily as an anti-inflammatory agent. It exhibits multiple biological activities, including anti-inflammatory, antidiabetic, antiviral, anticholinergic, and immunomodulatory effects. Amaroswerin effectively inhibits nitric oxide (NO) release in RAW264.7 cells, demonstrating an IC50 value of 5.42 μg/mL, making it a valuable tool for research in inflammation and related health conditions. -
iNOS Inhibitor
AMT hydrochloride is a selective inhibitor of inducible nitric oxide synthase (iNOS), with a Ki value of 4.2 nM. This compound effectively modulates nitric oxide production, making it a valuable tool for studying inflammatory responses and related signaling pathways. It is applicable in research examining the role of iNOS in various physiological and pathological conditions. -
NOS Inhibitor
D-NAME hydrochloride is a potent nitric oxide synthase (NOS) inhibitor. By inhibiting NOS activity, D-NAME hydrochloride effectively reduces nitric oxide production, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. This reagent can be applied in research related to cardiovascular disease, neurodegeneration, and inflammatory responses. -
Nonenzyme Glycation Inhibitor
Flazin is a non-enzymatic protein glycation inhibitor that targets glycation processes and peroxynitrite (ONOO-). It exhibits an IC50 value of 85.31 μM in inhibiting bovine serum albumin (BSA) glycation and an EC50 value of 71.99 μM for ONOO-. Flazin is valuable in research related to diabetes and neurodegenerative disorders and functions as a lipid droplet regulator, making it relevant for studies on lipid metabolism disorders. Additionally, it serves as an inhibitor of xanthine oxidase (XOD), further expanding its utility in various biochemical applications. -
NO Inhibitor
Carboxy-PTIO is a highly effective nitric oxide (NO) scavenger, facilitating the rapid reaction with NO to generate nitrogen dioxide (NO2). This compound demonstrates significant biological activity in preventing hypotension and endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. Carboxy-PTIO serves as a valuable tool in research focused on the roles of nitric oxide in various physiological and pathological processes. -
NO Synthase Inhibitor
Syzalterin is a potent inhibitor of nitric oxide synthase, demonstrating an IC50 value of 1.87 μg/mL. This compound effectively reduces NO production, making it valuable for research focused on nitric oxide-related signaling pathways and their implications in various physiological and pathological processes. Syzalterin can be utilized in studies exploring cardiovascular function, neurobiology, and inflammatory responses. -
NO Synthase Inhibitor
Cauloside C is a triterpene glycoside that acts as an inhibitor of nitric oxide synthase (NOS). It demonstrates significant anti-inflammatory properties by reducing the expression of inducible nitric oxide synthase (iNOS) and downregulating proinflammatory cytokines. This compound is a valuable tool for research focused on inflammation and related signaling pathways. -
NO Inhibitor
Futoquinol is a neolignan that acts as a nitric oxide (NO) inhibitor, derived from the dried aerial parts of Piper kadsura. This compound demonstrates potent inhibition of NO production in microglial cells, highlighting its potential in modulating neuroinflammatory processes. Futoquinol is valuable for research applications focused on neuroinflammation and related neurological disorders. -
NO Inhibitor
Panaxcerol B is a monogalactosyl monoacylglyceride characterized as a nitric oxide (NO) inhibitor. It exhibits an IC50 of 59.4 μM in inhibiting NO production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. This compound is valuable for research applications focused on inflammatory responses and related signaling pathways.
