Catalog No.
Product Name
Application
Product Information
Citations
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Inflammatory Pathway Inhibitor
(E)-Sinapoyl glucose is an inhibitor of inflammatory pathways, specifically targeting nitric oxide (NO) production. It demonstrates an IC50 value of 38.32 µM in RAW 264.7 macrophage cells, highlighting its potential in modulating inflammatory responses. This compound is valuable for research into inflammatory diseases and their underlying mechanisms. -
NO Inhibitor
Thunalbene is a stilbene derivative that acts as a nitric oxide (NO) inhibitor. It demonstrates a moderate inhibitory effect on nitric oxide production, making it a valuable tool for studies examining NO-related pathways. Additionally, Thunalbene has been shown to be non-cytotoxic, enabling its use in various biological assays without compromising cell viability. -
iNOS/ICAM-1 Inhibitor
Aloenin aglycone is an inhibitor of iNOS and ICAM-1, derived from aloe exudate. It effectively suppresses TNFα-induced NF-κB transcriptional activity with an IC50 of 18.7 μM. Additionally, at a concentration of 10 μM, it significantly reduces the expression of both inducible nitric oxide synthase (iNOS) and intercellular adhesion molecule 1 (ICAM-1) in HepG2 cells following TNFα stimulation. This compound serves as a valuable tool for investigating inflammatory pathways and potential therapeutic interventions in related conditions. -
Sesquiterpene
Alismol is a natural sesquiterpene that exhibits significant inhibitory effects on interferon-gamma (INF-γ)-induced nitric oxide production in murine macrophage RAW264.7 cells. This molecule serves as a valuable tool for studying inflammation and immune responses, particularly in the context of macrophage activation. Its potential applications extend to research in immunology and pharmacology, focusing on therapeutic strategies for inflammatory diseases. -
Fatty Acid Derivative
Echinochlorin A is a fatty acid derivative primarily derived from Echinochloa utilis. This compound exhibits notable biological activity, contributing to various metabolic processes. It serves as a valuable reagent for research in fatty acid metabolism and other biochemical pathways involving lipid-derived compounds. -
Antihypertensive Agent
Cicletanine hydrochloride is an orally active furopyridine derivative that functions as an antihypertensive agent primarily by stimulating nitric oxide (NO) release. This compound promotes effective pulmonary vasodilation, making it useful in the study of cardiovascular health and hypertension-related research. Its mechanisms may offer insights into potential therapeutic strategies for managing elevated blood pressure and related vascular conditions. -
NO Production Inhibitor
6-Methoxynaringenin is a natural flavonoid that functions as an inhibitor of nitric oxide (NO) production, exhibiting an IC50 of 25.8 μM. This compound is valuable for research focused on cardiovascular health and inflammation, where NO plays a critical role. Its ability to modulate NO levels makes it an important tool for studying various biochemical pathways and therapeutic interventions. -
NO Synthase Inhibitor
Ronopterin is a nitric oxide synthase (NOS) inhibitor, primarily utilized in research investigating the pathophysiology of urogenital and neurological disorders. By inhibiting NO production, Ronopterin modulates crucial signaling pathways, making it a valuable tool for studying conditions linked to dysregulated nitric oxide signaling. Applications include exploring the role of NO in various diseases and assessing therapeutic strategies targeting NOS pathways. -
Furanocoumarin
(Rac)-Isogosferol is a furanocoumarin derived from the fruits of Cnidium monnieri. It exhibits significant biological activity, including potential anti-inflammatory and antimicrobial properties. This compound is primarily utilized in research applications aimed at understanding its therapeutic effects and mechanisms of action within various biological systems. -
SPSB2-iNOS Inhibitor
SPSB2-iNOS inhibitory cyclic peptide-3 is a selective inhibitor targeting the interaction between SPSB2 and inducible nitric oxide synthase (iNOS). This compound binds to the SPSB2 site on iNOS with a dissociation constant (KD) of 7 nM. It demonstrates significant biological activity in modulating nitric oxide production and has potential applications in studies related to inflammation and oxidative stress. -
NOS Inhibitor
NOS-IN-2 is a selective inhibitor of nitric oxide synthase (NOS), primarily targeting inducible nitric oxide synthase (iNOS) with an IC50 of 20 µM, while sparing endothelial nitric oxide synthase (eNOS). Its low toxicity profile makes it suitable for research in inflammatory disorders and related pathways. NOS-IN-2 is an important tool for investigating the role of nitric oxide in various biological processes and for developing therapeutic strategies for conditions associated with elevated iNOS activity. -
NO Synthase Inhibitor
GW 273629 is a selective nitric oxide synthase inhibitor that effectively modulates nitric oxide production. This compound demonstrates significant anti-inflammatory activity, making it a valuable tool for research investigating inflammation-related pathways and conditions. Its specificity for nitric oxide synthase positions it as a suitable reagent for studies aimed at understanding the role of nitric oxide in various biological processes. -
NO Synthase Inhibitor
Cycloneroside C is a sesquiterpene aminoglycoside that functions as a nitric oxide synthase inhibitor. In studies utilizing RAW 264.7 macrophage cells, it demonstrated an IC50 value of 57.1 μM for the inhibition of nitric oxide production. This compound is primarily applied in research focused on anti-inflammatory mechanisms and potential therapeutic interventions. -
NO Synthase Inhibitor
Harzianoside B is a diterpene aminoglycoside known for its role as a nitric oxide (NO) synthase inhibitor. It effectively reduces NO production, demonstrating an IC50 value near the maximum tested concentration of 100 µM in RAW 264.7 macrophage cells. This compound is valuable for research into anti-inflammatory mechanisms and therapeutic applications. -
NO Synthesis Inhibitor
Schiarisanrin A is a lignan that acts as an inhibitor of nitric oxide (NO) synthesis. It demonstrates a significant inhibitory effect on NO production in BV-2 cells, with an IC50 value of 9.6 μM. This compound may serve as a valuable tool in research focused on inflammatory pathways and neuroprotection. -
Anti-inflammatory Agent
Tetrandrine 2'-N-α-oxide is a bisbenzylisoquinoline alkaloid known for its anti-inflammatory properties. Isolated from the roots of Stephania tetrandra, this compound may be utilized in studies investigating inflammatory diseases and their underlying mechanisms. Its ability to modulate inflammatory pathways makes it a valuable tool for researchers in the field of inflammatory responses. -
iNOS Inhibitor
Myricananin A is a selective inhibitor of inducible nitric oxide synthase (iNOS), effectively modulating nitric oxide production. This compound demonstrates significant anti-inflammatory properties, making it valuable for research in inflammation-related pathways and conditions. Myricananin A serves as a critical tool for elucidating the role of iNOS in various biological processes and may aid in the development of therapeutic strategies targeting iNOS-related diseases. -
Vasodilator
L-Arginine is a substrate for endothelial nitric oxide synthase (eNOS), facilitating the production of nitric oxide (NO). This compound acts as a potent vasodilator, influencing vascular tone and blood flow. It is commonly utilized in research applications related to cardiovascular studies and may also be employed to induce experimental acute pancreatitis. -
Anti-Inflammatory Agent
Morachalcone A is a naturally occurring compound that functions as an aromatase inhibitor, exhibiting an IC50 value of 4.6 mM. It possesses significant anti-inflammatory and potential anticancer activities by inhibiting lipopolysaccharide-induced nitric oxide production. Morachalcone A is valuable for research focused on inflammation and cancer biology. -
NO Synthase Inhibitor
Chloranthalactone E is a labdane diterpene that acts as an inhibitor of nitric oxide synthase (NOS). It effectively reduces nitric oxide production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages, making it a valuable tool for studying inflammatory pathways. This compound is useful in research focused on immune responses and the modulation of macrophage activity. -
NO donor
LA-419 is an orally active nitric oxide (NO) donor that effectively reduces fecal worm egg excretion and shortens the duration of egg shedding in mice infected with S. venezuelensis. Additionally, it decreases the larval load in the lungs and the count of parasitic females in the intestines. LA-419 also demonstrates protective effects against atherosclerosis in apolipoprotein E-deficient mice, making it valuable for studies in infection and cardiovascular diseases. -
NO Synthase Inhibitor
Mercaptoethylguanidine (MEG) dihydrobromide is a selective inhibitor of inducible nitric oxide synthase, acting as a peroxynitrite scavenger. This compound exhibits significant anti-inflammatory properties, making it a valuable tool for research into inflammatory bowel diseases and related conditions. Its ability to modulate nitric oxide production makes MEG an important reagent for studies focusing on nitric oxide-related pathologies. -
NO Production Inhibitor
Dimeric coniferyl acetate is an inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 7.9 μM in BV-2 microglial cells. This compound is valuable for research applications aimed at understanding the regulation of NO synthesis and its implications in neuroinflammatory processes. Its specificity and potency make it a useful tool for studying the role of NO in cellular signaling and neurobiology. -
Anti-inflammatory Agent
2,4-Dihydroxy-6-methoxy-3,5-diprenylacetophenone is an acetophenone derivative primarily functioning as an anti-inflammatory agent. It exhibits significant anti-inflammatory and antioxidant activities, including the inhibition of LPS-induced nitric oxide production with an IC50 of 34.5 μM, and a SC50 value of 0.15 mM for DPPH free radical scavenging. This compound is valuable for investigating mechanisms underlying inflammation and oxidative stress in various research settings. -
Cardiac Protectant
RC-552 is a novel synthetic glycolipid that acts as a cardiac protectant through an inducible nitric oxide synthase (iNOS)-dependent mechanism. This compound has demonstrated the ability to attenuate myocardial stunning, providing delayed cardioprotective effects. It is valuable in research focused on cardiac ischemia and myocardial injury, offering insights into potential therapeutic strategies for heart-related conditions. -
Nitric Oxide Inhibitor
(+)-Hannokinol is a nitric oxide inhibitor derived from the fruit of AMOMUM TSAO-KO, a member of the ginger family. This compound effectively inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglia, making it a valuable tool for studies related to neuroinflammation and oxidative stress. Its biological activity contributes to research in various fields, including neurobiology and immunology. -
Anti-inflammatory Agent
12-Acetoxyganoderic acid D is a triterpenoid compound derived from Ganoderma sinense, primarily known for its anti-inflammatory properties. It effectively inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, demonstrating its potential as a therapeutic agent. This compound is valuable for research in inflammation and related biological pathways. -
NOS Inhibitor
Guanidino ethyl disulfide is a selective nitric oxide synthase (NOS) inhibitor, showing EC50 values of 110 μM for iNOS, 630 μM for eNOS, and 180 μM for bNOS. This compound effectively inhibits nitrite production in J774.2 macrophages, making it a valuable tool for studying mechanisms of nitric oxide modulation. Guanidino ethyl disulfide can be utilized in research related to circulatory shock, inflammation, and neurological disorders. -
Nitric Oxide Inhibitor
Kansuinine E is a jatrophane-type diterpenoid that acts as a nitric oxide inhibitor with an IC50 of 6.3 μM. Isolated from the roots of Euphorbia kansui, this compound demonstrates significant biological activity by modulating nitric oxide levels. Kansuinine E is primarily utilized in research applications focusing on vascular biology and the study of nitric oxide-related pathways. -
Triterpene
11-Deoxyalisol B is a triterpene known for its potent inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. This compound has significant implications for research into inflammatory responses and immune modulation. Its ability to modulate nitric oxide levels makes it a valuable reagent for studying mechanisms underlying various inflammatory diseases. -
NO Inhibitor
Isolupalbigenin is a nitric oxide (NO) inhibitor that exhibits significant anti-proliferative activity against HL-60 human leukemia cells, with an IC50 value of 5.1 μM. This compound is useful in research applications focused on the modulation of nitric oxide signaling pathways and the exploration of therapeutic strategies for leukemia and related disorders. -
NO Production Inhibitor
O-Acetylschisantherin L is a natural lignan that serves as an inhibitor of nitric oxide (NO) production. It effectively suppresses LPS-induced NO production in BV-2 cells, demonstrating an IC50 value of 23.1 μM. This compound is useful in research focused on neuroinflammation and associated signaling pathways. -
NOS Inhibitor
NOS-IN-3 is a selective inhibitor of nitric oxide synthase (NOS) with a notable affinity for inducible nitric oxide synthase (iNOS), exhibiting an IC50 of 4.6 μM, while sparing endothelial nitric oxide synthase (eNOS). This compound demonstrates minimal toxicity, making it suitable for investigations into diseases associated with the inducible isoform, such as septic shock. NOS-IN-3 is a valuable tool for elucidating the role of iNOS in various pathological conditions. -
Anti-inflammatory Agent
Anti-inflammatory agent 19 is a potent anti-inflammatory agent that targets HMGB1-induced inflammation. With an IC50 of 36.00 μM, it effectively inhibits the downstream inflammatory response, making it a valuable tool in the study of chronic inflammatory conditions. This compound is suitable for research applications related to inflammatory diseases, including COVID-19 and sepsis. -
NO Production Inhibitor
Valeriandoid F is an iridoid compound that acts as a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 0.88 μM. This reagent possesses anti-inflammatory and antiproliferative properties, making it beneficial for studies related to inflammation and cancer research. Its ability to modulate NO levels may also provide insights into various pathological conditions associated with dysregulated nitric oxide signaling. -
Antitumor Agent
Antitumor Agent-49 is a harmine derivative-furoxan hybrid that acts as an antitumor agent. This compound exhibits significant cytotoxic activity against HepG2 cells, with an IC50 of 1.79 µM, indicating its potential effectiveness in cancer research. Additionally, Antitumor Agent-49 generates elevated levels of nitric oxide (NO) in vitro, making it a valuable tool for investigating antitumor mechanisms and therapeutic strategies. -
NO Inhibitor
Britannilactone diacetate is a notable nitric oxide (NO) inhibitor, demonstrating significant efficacy in reducing NO production induced by lipopolysaccharide (LPS) in BV-2 microglial cells, with an effective concentration (EC50) of 6.3 μM. This compound is characterized by its favorable penetration across the blood-brain barrier, along with promising absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiles, making it a valuable tool for investigating NO-related neuroinflammatory processes. Its unique mechanisms and properties position it for various research applications in neurobiology and pharmacology. -
Chalcone Derivative
2′-Hydroxy-2,3-dimethoxychalcone is a chalcone derivative that exhibits anti-inflammatory properties. It effectively inhibits the production of nitric oxide through the inhibition of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. This compound is valuable for research applications focused on the modulation of inflammatory responses and the investigation of nitric oxide pathways in various biological systems. -
Plant Growth Regulator
N-Isobutyl decanamide is a plant growth regulator that enhances the development of adventitious and lateral roots in Arabidopsis thaliana hypocotyl and taproot explants, respectively. It promotes root formation by inducing the accumulation of nitric oxide (NO) in the areas of active adventitious root generation. This compound is valuable for research applications focused on root development and plant physiology. -
Anti-inflammatory Agent
Apterin is a natural compound that functions as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. In RAW264.7 cells, Apterin demonstrates significant inhibitory activity with an IC50 value of 41.8 μM. This compound is useful for research focused on inflammatory pathways and the modulation of immune responses. -
iNOS Inhibitor
BYK 191023 is a selective inhibitor of inducible nitric-oxide synthase (iNOS) that functions as an L-arginine competitive antagonist, exhibiting an IC50 value of 86 nM for iNOS, while displaying significantly higher IC50 values of 17 µM and 162 µM for neuronal (nNOS) and endothelial (eNOS) nitric-oxide synthases, respectively. This compound is vital for studying the role of iNOS in various pathological conditions and demonstrates potential applications in inflammation research and related disease models. -
NO Production Inhibitor
9-Hydroxy-α-lapachone is a natural phenolic compound that serves as an effective nitric oxide (NO) production inhibitor. It demonstrates significant inhibitory activity, with an IC50 value of 4.64 µM, against LPS-induced NO production in RAW 264.7 macrophage cells. This compound is utilized in research applications focused on understanding inflammatory responses and nitric oxide signaling pathways. -
NO Synthase Inhibitor
1,3-PBIT dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a Ki value of 47 nM. In contrast, it shows reduced inhibition for endothelial (eNOS) and neuronal nitric oxide synthase (nNOS), with Ki values of 9 µM and 0.25 µM, respectively, for purified human enzymes. While it effectively inhibits iNOS in vitro, its cellular activity may be limited by membrane permeability, making it primarily useful for biochemical studies on nitric oxide pathways and their related regulatory mechanisms. -
Cancer Biomarker
8-Nitroguanine is a product of nitrative DNA damage resulting from reactive nitrogen species and serves as a potential biomarker for cancer progression. This compound is particularly relevant in the study of malignant fibrous histiocytoma, providing insights into tumor development and response to treatment. Its role in oxidative stress pathways makes it a valuable tool for researchers investigating mechanisms of DNA damage and repair in cancer biology. -
Analgesic Agent
Dipyrocetyl is an analgesic agent that exhibits anti-inflammatory properties. This compound is utilized in research applications focused on pain management and inflammation pathways, providing valuable insights into potential therapeutic interventions for various inflammatory disorders. Its mechanism of action makes it a significant candidate for studies aimed at understanding pain relief mechanisms. -
NO Production Inhibitor
Sinomenine N-oxide is a potent inhibitor of nitric oxide (NO) production, exhibiting an IC50 value of 23.04 μM. This compound demonstrates significant anti-angiogenic, anti-inflammatory, and anti-rheumatic properties, making it valuable for research in cardiovascular and inflammatory diseases. Its mechanisms may offer insights into therapeutic approaches for conditions characterized by excess NO production. -
NO Inhibitor
Diplacol is a geranylated flavanone that functions as a nitric oxide (NO) inhibitor. Isolated from Paulownia coreana UYEKI, Diplacol exhibits notable anti-inflammatory activity. It effectively reduces NO production in LPS-stimulated Raw264.7 macrophage cells, with an IC50 value of 4.53 μM, making it a valuable reagent for studies focusing on inflammation and related signaling pathways. -
NOS Inhibitor
L-NAPNA is a selective nitric oxide synthase (NOS) inhibitor, demonstrated to have an IC50 of 1.4 μM. It exhibits significant analgesic effects, as evidenced by its ability to reduce formalin-induced paw licking behavior in mice (ED50 of 57.2 mg/kg) and diminish acetic acid-induced abdominal writhing (ED50 of 25 mg/kg). This compound is valuable for exploring therapeutic approaches in research focused on central nervous system disorders. -
Guanidino Compound
α-Guanidinoglutaric acid is a guanidino compound that has been identified in cobalt-induced epileptogenic foci within the cerebral cortex of feline subjects. This compound is known to induce epileptic seizures in rodent models following intraventricular administration, making it a valuable tool for studying the mechanisms of epilepsy and related neurological disorders. Its application is particularly relevant in pharmacological studies aimed at elucidating seizure activity and potential therapeutic interventions. -
NO Synthase Inhibitor
Corydaldine is an alkaloid that acts as an inhibitor of nitric oxide synthase (NOS). It has been shown to effectively reduce nitric oxide production in BV2 microglial cells upon stimulation with lipopolysaccharide (LPS). This compound is relevant for research focusing on neuroinflammation and the roles of nitric oxide in various neurodegenerative diseases.
