Catalog No.
Product Name
Application
Product Information
Citations
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SIK Inhibitor
SIK-IN-1 is a potent inhibitor of salt-inducible kinases (SIK1, SIK2, and SIK3), exhibiting IC50 values of 0.1 nM, 0.4 nM, and 1.5 nM, respectively. This compound effectively inhibits the release of TNF-alpha with an IC50 of 0.5 nM and promotes LPS-induced IL-10 release, demonstrating an EC50 of 4 nM in human macrophages. SIK-IN-1 is a valuable tool for research investigating inflammatory responses and macrophage polarization. -
SIK Inhibitor
SIK-IN-2 is a potent inhibitor of salt-inducible kinases (SIK), selectively targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.2, and 0.4 nM, respectively. This compound has demonstrated significant biological activity by inhibiting the release of TNF-alpha with an IC50 of 0.5 nM and enhancing LPS-induced IL-10 release in human macrophages with an EC50 of 2 nM. SIK-IN-2 is valuable for research applications focused on inflammatory responses and immune modulation. -
AMPK/Nrf2 Activator
Ethyl (E)-ferulate is an activator of the AMPK/Nrf2 signaling pathway, demonstrating significant potential in reducing acute lung injury induced by lipopolysaccharide. This compound exhibits antioxidant and free radical scavenging properties, contributing to its anti-inflammatory and neuroprotective effects. Ethyl (E)-ferulate is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
CRBN Degrader
WDR5 Degrader-1 is a cereblon (CRBN)-recruiting compound designed to selectively induce degradation of the WDR5 protein. This degrader effectively targets WDR5 while sparing the CRBN neo-substrate IKZF1, facilitating precise manipulation of WDR5 levels in cellular systems. It is a valuable tool for investigating the biological roles of WDR5 in transcriptional regulation and potential therapeutic strategies in diseases associated with dysregulated WDR5 expression. -
A2AR Antagonist
A2AR-antagonist-1 is a selective adenosine A2A receptor (A2AR) antagonist with an IC50 of 29 nM. This compound demonstrates significant anti-tumor activity and maintains metabolic stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally, A2AR-antagonist-1 activates T cells by inhibiting immunosuppressive molecules such as LAG-3 and TIM-3, while promoting the expression of effector molecules including GZMB, IFNG, and IL-2, making it a valuable tool in cancer immunotherapy research. -
SIK2/3 Inhibitor
SIK2/3-IN-2 is a potent inhibitor of salt-inducible kinases 2 and 3 (SIK2 and SIK3), with IC50 values of 65 nM and 14 nM, respectively. Additionally, it acts as a p21-activated protein kinase (PAK) 1 inhibitor with a Ki of 20.7 nM. This compound is valuable for investigating hyperproliferative diseases and cancer, particularly in studies related to Paclitaxel-resistant ovarian cancer. -
Anti-Inflammatory Agent
Cholesterol sulfate is a naturally occurring cholesterol derivative that functions as a DOCK2 inhibitor, exhibiting IC50 values of 2 μM for mouse targets and 2.9 μM for human targets. This compound shows significant anti-inflammatory activity by limiting neutrophil infiltration and mitigating intestinal inflammation and damage. Additionally, it activates protein kinase C (PKC), facilitating squamous cell differentiation and inhibiting skin carcinogenesis. Cholesterol sulfate is relevant for research applications in conditions such as actinic keratitis, ulcerative colitis, and skin cancer, and it plays a role in regulating cholesterol homeostasis and cellular metabolism via the AMPK-Sirt1 pathway. -
CypD Inhibitor
CypD-IN-5 is a selective inhibitor of cyclophilin D (CypD), a key regulator of mitochondrial permeability transition. This compound demonstrates significant potential in modulating mitochondrial function and may be particularly useful in studying neurodegenerative diseases such as Alzheimer's disease. Its application in research focuses on understanding the role of CypD in cellular stress responses and the underlying mechanisms of neurodegeneration. -
Anti-CLDN18/CD3E Antibody
Emaretamig is a humanized IgG1κ monoclonal antibody that selectively targets CLDN18 and CD3E. This compound exhibits significant anti-tumor efficacy and is primarily employed in research on gastric and pancreatic cancers. Its mechanism of action facilitates T-cell engagement with tumor cells, enhancing immune-mediated responses against malignancies expressing these antigens. -
Anti CLDN18.2 & CD3E Antibody
Lumivatamig is a bispecific antibody designed to target CLDN18.2 and CD3E, facilitating T-cell-mediated cytotoxicity against CLDN18.2-expressing tumors. This dimer-type H-γ1_L-κ-scFvhl antibody is employed in cancer immunotherapy research to enhance anti-tumor immune responses. Its ability to bridge tumor cells and T cells may contribute to improved therapeutic outcomes in clinical applications targeting gastric and pancreatic cancers. -
TLR7 Agonist
TLR7 Agonist 12 is a potent TLR7 agonist and a purine nucleoside analog. This compound demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are mediated through the inhibition of DNA synthesis and the induction of apoptosis, making it valuable for research applications in cancer therapeutics and immune modulation studies. -
Anti-Albumin/FOLR1/CD3 Antibody
Eliroptamig is a multispecific antibody that targets albumin, folate receptor α (FOLR1), and cluster of differentiation 3 (CD3). This antibody enhances its half-life through binding to albumin, while effectively targeting FOLR1 on tumor cells and engaging T cells to facilitate targeted tumor destruction. It is valuable in cancer research applications, particularly in studies focusing on immunotherapy and tumor microenvironment interactions. -
Small Molecule-drug Conjugate
OncoFAP-GlyPro-MMAE is a small molecule-drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 0.49 nM. This compound combines the selective FAP ligand OncoFAP with the tubulin inhibitor MMAE, linked for optimized delivery. OncoFAP-GlyPro-MMAE demonstrates significant cytotoxic activity and is suitable for research applications in renal cancer and related malignancies. -
Microtubule-Targeting Agent
DZ-2384 is a powerful microtubule-targeting agent known for its role in enhancing rescue frequency and maintaining the microtubule architecture in nonmitotic cells and primary neurons. This compound demonstrates synergistic effects when combined with anti-CTLA-4 immunotherapy, particularly in Taxane-sensitive and resistant xenograft models of triple-negative breast cancer (TNBC). Additionally, DZ-2384 exhibits significant antitumor efficacy in models of adult acute lymphocytic leukemia (ALL), making it a valuable tool for cancer research in these areas. -
Anti-neuroinflammatory Agent
SB26019 is a potent anti-neuroinflammatory agent that primarily targets NF-κB activation. It functions by promoting the formation of monomeric α-tubulin, which in turn inhibits the translocation of the p65 subunit of NF-κB. This mechanism underscores its potential application in neuroscience research, particularly in studies related to neuroinflammation and associated disorders. -
NEK7 Molecular Glue Degrader
NEK7 degrader-3 is an orally active NEK7 molecular glue degrader with a DC50 of 33.1 nM, which effectively mediates the interaction between NEK7 and the E3 ligase cereblon, leading to the proteasomal degradation of NEK7. This degradation process attenuates NLRP3 inflammasome-mediated inflammatory responses, resulting in the inhibition of caspase-1 activity and the release of pro-inflammatory cytokines IL-1β, IL-1α, and IL-18. NEK7 degrader-3 demonstrates significant anti-inflammatory effects in LPS-induced neuroinflammation mouse models, serving as a valuable tool for research focused on neuroinflammation. -
Octamer Peptide
OVA Peptide (257-264) is an octameric peptide epitope derived from ovalbumin that is specifically presented by the class I major histocompatibility complex (MHC) molecule H-2Kb. This peptide is crucial for T cell recognition and activation in immunological studies. It has applications in the development of immunotherapies, vaccine research, and studies focusing on T cell responses. -
Immunodominant Antigen
AH1 is an MHC class I-restricted tumor-specific antigenic peptide that engages the murine MHC class I molecule Ld. Derived from the envelope protein (gp70) of the endogenous ecotropic murine leukemia virus (MuLV), AH1 serves as an immunodominant CTL epitope in CT26 colon carcinoma and TS/A murine mammary adenocarcinoma. The specific CTLs that recognize AH1 can effectively mediate cytotoxicity, leading to tumor cell killing and rejection. This peptide is valuable for research applications targeting tumor immunology and the development of cancer immunotherapies. -
Kb-restricted Epitope
KSPWFTTL is an immunodominant Kb-restricted epitope derived from the p15E transmembrane protein. This peptide effectively enhances the susceptibility of tumor lines to cytotoxic T lymphocytes specific for anti-AKR/Gross MuLV. KSPWFTTL is valuable for research applications focused on tumor immunology and T cell-mediated responses. -
EAE Inducer
MOG (35-55), human is a peptide derived from myelin oligodendrocyte glycoprotein, primarily functioning as an EAE inducer. This peptide possesses unique immunogenic properties as it binds to H-2b class II MHC and is recognized by T cells, facilitating the study of autoimmune responses in the central nervous system. Although it is associated with minimal clinical signs of experimental autoimmune encephalomyelitis compared to its rodent counterpart, mMOG (35-55), it is crucial for understanding the mechanisms of demyelination and neuroinflammation. Research applications include model development for multiple sclerosis and the exploration of T cell activation in autoimmune diseases. -
Glycol
1,10-Decanediol is a diol compound that interacts with α-ketoglutarate (aKG) to form polymeric microparticles (paKG MPs) for the controlled release of aKG, facilitating immunosuppressive responses. These microparticles can engage dendritic cells (DCs), leading to decreased glycolysis and mitochondrial respiration, which subsequently modulate MHC-II and CD86 expression in DCs and influence the proportions of regulatory T cells (Tregs) and various T-helper cell subsets in vitro. This compound serves as a valuable tool in immunometabolism research and functions as a surfactant/stabilizer in nanomaterial synthesis. -
Antigen Peptide
OVA(250-264) is an antigenic peptide derived from ovalbumin, targeting the class I MHC molecule H-2Kb. This peptide has been shown to significantly enhance the generation and infiltration of antigen-specific CD8+ T cells when used in conjunction with αMSLN (anti-MSLN antibody), thus improving antitumor efficacy in orthotopic models of pancreatic cancer. OVA(250-264) serves as a valuable tool for the development of neoantigen vaccines in immunotherapy research focused on pancreatic cancer. -
HLA-DR Binding Epitope
PADRE peptide is a pan-HLA-DR binding epitope that functions as an immunostimulant by binding to the peptide-binding groove of MHC class II molecules, facilitating the activation of CD4+ T cells. This leads to enhanced anti-tumor immune responses, inhibition of tumor growth, and prolonged survival in model systems. PADRE peptide is effective in increasing the frequency of E7-specific CD8+ T cells and improving therapeutic outcomes when combined with E7 peptide-based vaccines and poly (I:C). It is suitable for research applications in various tumor models, including melanoma, glioblastoma, and cervical cancer. -
MR1 Ligand
DB28 is an innovative MR1 ligand that functions by competitively inhibiting the activation of mucosal-associated invariant T (MAIT) cells through its interaction with MR1. Additionally, DB28 reduces the cell surface expression of MR1, making it a valuable tool for studies of MAIT cell biology and immune modulation. This compound is applicable in research focused on immune responses and potential therapeutic interventions targeting MR1-related pathways. -
GAD65 Residue
GAD65 (206-220) is a peptide derived from glutamic acid decarboxylase (GAD) 65, specifically corresponding to residues 206-220. It plays a pivotal role in immune recognition, as it is presented to T cells by I-Ag7 MHC class II molecules. This peptide is significant for research related to type I diabetes mellitus, where it is targeted by self-reactive T cells, aiding in the understanding of autoimmune responses. -
CD8-related Self-antigenic Epitope
Myelin Oligodendrocyte Glycoprotein (40-54) serves as a CD8-related self-antigenic epitope derived from the myelin oligodendrocyte glycoprotein (MOG) and is presented in association with H-2Db. This peptide is crucial for studying autoimmune responses in experimental models, particularly in the context of multiple sclerosis research. It can be utilized in assays to investigate T cell activation and epitope-specific immune responses in both rat and mouse models. -
T Cell Inducing Determinant
Hemoglobin (64-76) serves as a T cell inducing determinant that interacts with two distinct MHC class II molecules, utilizing different registers and lengths. This interaction is crucial for T cell activation and modulation, making it an important reagent for immunological research. Its biological activity facilitates studies on T cell responses, antigen presentation, and the development of therapeutic strategies in autoimmune and infectious diseases. -
Nucleoprotein Peptide
H2-D b restricted epitopes VSV Nucleoprotein (52-59) is a 9-mer peptide specifically derived from the nucleoprotein of Vesicular Stomatitis Virus (VSV). This peptide interacts with MHC class I molecules, facilitating the presentation to CD8+ T cells and promoting the activation of cytotoxic T lymphocytes (CTLs). It is particularly valuable in research focused on CTL vaccine development for infectious diseases, including Ebola virus, enhancing understanding of immune responses in viral infections. -
HLA-E Ligand
VMAPRTLFL is a 9-mer peptide that acts as a ligand for HLA-E, derived from the signal peptide of HLA-G. This peptide is essential for modulating the activity of adaptive natural killer (NK) cells, enhancing their proliferation, antibody-dependent cellular cytotoxicity (ADCC), and interferon-gamma (IFN-γ) release through upregulation of CD25 expression. VMAPRTLFL is valuable for research into human cytomegalovirus (HCMV) infection, transplant rejection, and mechanisms underlying pregnancy immunity. -
HLA-B7-Derived Peptide
Allotrap 07 is a synthetic peptide derived from residues 75-84 of the HLA-B7 molecule, a class I major histocompatibility complex (MHC) protein. This peptide is known for its ability to promote donor-specific tolerance in rat cardiac allografts when used in conjunction with Cyclosporin A, leading to a significant extension of graft survival. Allotrap 07 is a valuable tool for researchers exploring mechanisms of immune tolerance and transplant biology. -
HLA-Cw*1601 Binder
BAGE (2-10) is a nonapeptide encoded by the BAGE gene that specifically binds to the HLA-Cw*1601 molecule. This interaction facilitates the formation of an antigen recognized by autologous cytotoxic T lymphocytes, making BAGE (2-10) useful in studies related to melanoma. Its ability to elicit an immune response positions it as a valuable tool for research in cancer immunotherapy and antigen presentation. -
MHC Peptide
SEIDLILGY is a nonapeptide that acts as a ligand for major histocompatibility complex class I (MHC) molecules, derived from mouse sources. This compound is primarily used to stimulate sensory neurons expressing the vomeronasal receptor V2rf2, facilitating studies in neural signaling and sensory processing. Its unique properties make it an invaluable tool for research in neurobiology and immunology. -
T-Helper Epitope
TpD is a chimeric T-helper epitope designed to elicit robust immune responses via targeted binding to various human MHC class II molecules, predominantly HLA-DRB1. Facilitating cleavage by cathepsins, TpD effectively promotes long-term CD4+ T-cell responses, making it a valuable tool in immunization strategies. Its ability to bind to multiple HLA alleles, including DRB3, DRB4, DRB5, DP, and DQ, enhances its utility in optimizing peptide vaccine efficacy and advancing research in immunology and vaccine development. -
Melanoma Antigen-Derived Peptide
VLPDVFIRCV is a melanoma antigen-derived peptide that targets MHC-I class molecules. It has been shown to induce cytotoxic T lymphocytes (CTLs) capable of specifically lysing T2 cells pre-loaded with this peptide in chromium release assays. While VLPDVFIRCV does not activate immune responses against natural tumor cells, it is valuable for vaccine design research and studies focused on immune modulation in melanoma. -
Inhibitor Of The Binding Of DQ8 Peptide To MHC Class II Molecule
D-α-Methyl DOPA is an inhibitor of the binding of DQ8 peptide to MHC class II molecules. By occupying a pocket in the DQ8 peptide binding groove, D-α-Methyl DOPA disrupts the presentation of DQ8 peptides to CD4+ T cells. This inhibition may play a role in modulating the immune response, potentially slowing the development or progression of type 1 diabetes and celiac disease. This compound is valuable in immunological research focused on T cell activation and autoimmune disease mechanisms. -
e14a2 Junctional Sequence
GFKQSSKAL is an e14a2 junctional sequence that specifically binds to HLA-B8. This binding interaction is relevant for investigating T cell responses and immunological applications in chronic myeloid leukemia (CML) research. GFKQSSKAL can be utilized in studies focused on cancer immunotherapy and the mechanisms of immune evasion in hematological malignancies. -
MHC class II Antigen Presentation Modulator
Ac-YR-NH2 is a small molecule that modulates MHC class II antigen presentation. By influencing peptide binding to MHC class II, Ac-YR-NH2 can alter immune responses, making it a valuable tool for studying immune system dynamics. This compound is particularly useful in research applications focused on autoimmune diseases and vaccine development, where modulation of antigen presentation is critical. -
MHC II Antigen Loading Catalyst
AdCaPy is an MHC II antigen loading catalyst that facilitates the efficient loading of peptide antigens onto MHC II molecules. By enhancing the presentation of antigens to CD4+ T cells, AdCaPy plays a crucial role in modulating immune responses. This reagent is valuable for research applications in immunology, vaccine development, and therapeutic strategies targeting T cell activation. -
NO Production Inhibitor
N-Phthaloyl-L-glutamic acid is a nitric oxide production inhibitor that effectively reduces lipopolysaccharide (LPS)-induced nitric oxide synthesis in murine spleen cells. This compound serves as a potential anti-inflammatory agent, demonstrating low cytotoxicity in vitro against tumor cells and in BALB/c mice spleen cell cultures. N-Phthaloyl-L-glutamic acid is suitable for research investigating mechanisms of inflammation and associated therapeutic approaches. -
Anti-inflammatory Agent
Sutherlandin trans-p-coumarate is a selective γ-hydroxynitrile glycoside that acts as an anti-inflammatory agent by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages, demonstrating 56.9% inhibition at a concentration of 25 μg/mL. This compound can be naturally extracted from the dried aerial parts of Sorbaria sorbifolia, a member of the Rosaceae family. Due to its biological activity, it is of interest in research focused on inflammation and immune response modulation. -
Nitric oxide donor
S-Nitroso-N-acetyl-DL-penicillamine is a nitric oxide donor that serves as a stable inhibitor of platelet aggregation. It releases nitric oxide in biological systems, thereby contributing to vasodilation and modulation of inflammatory responses. This compound is widely utilized in research related to cardiovascular studies and low blood flow conditions, as well as in investigations of nitric oxide's role in cellular signaling and pathophysiology. -
NO Donor
DETA NONOate is a highly effective exogenous nitric oxide (NO) donor. It releases NO slowly and in controlled amounts, providing long-lasting effects. This compound is widely used in research applications to study NO-mediated physiological processes, such as vasodilation, neuronal signaling, and immune responses. DETA NONOate's stable release profile makes it particularly suitable for in vitro and in vivo studies investigating the role of nitric oxide in various biological systems. -
Monocarboxylic Acid Amide
Lipoamide is a monocarboxylic acid amide that serves as a crucial coenzyme in cellular metabolism, facilitating the transfer of acetyl groups and hydrogen during pyruvate decarboxylation. This compound exhibits protective effects against oxidative stress-induced neuronal cell damage. Additionally, lipoamide plays a significant role in promoting mitochondrial biogenesis in adipocytes through the endothelial nitric oxide synthase-cGMP-protein kinase G signaling pathway, making it valuable for research in metabolic disorders and neuroprotection. -
Porphyrin Complex
Ferroheme is the ferrous form of heme that functions primarily as an oxygen carrier through reversible oxygen binding. Its free form is known to induce oxidative stress and ferroptosis by releasing iron ions, which facilitate the generation of reactive oxygen species via Fenton reactions. This mechanism plays a significant role in pathological conditions such as intracerebral hemorrhage and neurodegenerative diseases, making Ferroheme a valuable reagent for research into iron-overload disorders and the mechanisms underlying ferroptosis-related pathologies. -
NO Inhibitor
Carboxy-PTIO potassium is a potent nitric oxide (NO) inhibitor that facilitates the rapid reaction with NO to yield nitrogen dioxide (NO2). This compound exhibits significant biological activity by preventing hypotension and alleviating endotoxic shock, particularly in lipopolysaccharide-stimulated rat models. It serves as a valuable reagent for researchers investigating the role of nitric oxide in various physiological and pathophysiological processes. -
Glycosaminoglycan
Chondroitin sulfate sodium (from shark cartilage) is a glycosaminoglycan that plays a critical role in cartilage structure and function. It exhibits significant anti-inflammatory properties by reducing the production of inflammatory cytokines, inducible nitric oxide synthase (iNOS), and matrix metalloproteinases (MMPs). This compound is commonly investigated in therapeutic research focused on osteoarthritis and other joint disorders, where it supports cartilage health and alleviates symptoms associated with inflammation. -
NO Scavenger
PTIO is a selective nitric oxide (NO) scavenger and redox mediator. It reacts with nitric oxide to produce imino nitroxides and nitrogen dioxide, effectively mitigating the effects of NO in biological systems. PTIO also enhances the oxidation of organic contaminants by permanganate, making it valuable in studies involving redox chemistry and environmental research. Its applications include investigating NO-related signaling pathways and assessing oxidative stress in various biological contexts. -
NOS Uncoupling Inducer
7,8-Dihydro-L-biopterin serves as a nitric oxide synthase (NOS) uncoupling inducer and is capable of crossing the blood-brain barrier. As a reduced, non-conjugated pteridine and the primary metabolite of 4-amino-tetrahydro-L-biopterin, it promotes the conversion of NOS to a superoxide-producing form, elevating oxidative stress levels, particularly in the renal outer medulla, and triggering apoptosis. This compound's sensitivity to superoxide dismutase (SOD) inhibition makes it valuable for research into salt-sensitive hypertension, traumatic brain injury, and neurodegenerative diseases. -
NO Donor
Spermine NONOate is a nitric oxide (NO) donor characterized by its ability to release NO in aqueous solutions. This compound facilitates various biological processes, including vasodilation and signaling pathways associated with cardiovascular health. Spermine NONOate is commonly utilized in research applications focusing on nitric oxide's role in cellular communication and its implications in various physiological and pathological conditions. -
NO Synthase Inhibitor
L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). It demonstrates significant inhibition of nitric oxide production, making it a valuable tool for studying inflammatory pathways and the role of iNOS in various disease models. This compound is utilized in research applications focused on neurodegeneration, cancer, and cardiovascular disease, providing insights into the mechanisms of nitric oxide-mediated signaling.
