GSK2245035 maleate is a selective intranasal agonist of Toll-Like receptor 7 (TLR7), exhibiting potent Type-1 interferon (IFN) stimulating activity with pEC50 values of 9.3 for IFNα and 6.5 for TNFα. This compound effectively reduces allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is primarily utilized in research focused on asthma and other Th2-mediated allergic responses.
GSK2245035 maleate is a selective intranasal agonist of Toll-Like receptor 7 (TLR7), exhibiting potent Type-1 interferon (IFN) stimulating activity with pEC50 values of 9.3 for IFNα and 6.5 for TNFα. This compound effectively reduces allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is primarily utilized in research focused on asthma and other Th2-mediated allergic responses.
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