ETI60 is a selective Toll-like receptor (TLR) inhibitor that primarily targets the nucleoside-binding Site I on TLR7 and TLR9, with IC50 values of 0.68 μM and 0.12 μM, respectively. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, demonstrating nanomolar activity in cellular, biophysical, and in vivo assays. ETI60 modulates the expression of inflammation-related genes and has shown efficacy in alleviating symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). This reagent is valuable for research involving autoimmune and inflammatory diseases.
ETI60 is a selective Toll-like receptor (TLR) inhibitor that primarily targets the nucleoside-binding Site I on TLR7 and TLR9, with IC50 values of 0.68 μM and 0.12 μM, respectively. This compound effectively inhibits endosomal TLR-mediated pro-inflammatory signaling, demonstrating nanomolar activity in cellular, biophysical, and in vivo assays. ETI60 modulates the expression of inflammation-related genes and has shown efficacy in alleviating symptoms in mouse models of psoriasis and systemic lupus erythematosus (SLE). This reagent is valuable for research involving autoimmune and inflammatory diseases.
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