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Vemurafenib-d5

Stable Isotope

Vemurafenib-d5 is a deuterium-labeled analogue of Vemurafenib, a selective and potent inhibitor of B-RAF kinase, targeting the RAFV600E mutation with an IC50 of 31 nM, and c-RAF-1 with an IC50 of 48 nM. This reagent is crucial for studies involving B-RAF signaling pathways and can facilitate the investigation of drug metabolism and pharmacokinetics. Vemurafenib-d5 is especially useful in cancer research, particularly in evaluating autophagy induction and treatment responses in B-RAF mutant tumors.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1365986-90-8
Applications	Stable Isotope
Formula	C₂₃H₁₃D₅ClF₂N₃O₃S
Molecular Weight	494.95
SMILES	C(=O)(C=1C=2C(NC1)=NC=C(C2)C3=CC=C(Cl)C=C3)C4=C(F)C(NS(CC(C([2H])([2H])[2H])([2H])[2H])(=O)=O)=CC=C4F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.