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Binimetinib-d4

Stable Isotope

Binimetinib-d4 is a deuterium-labeled analogue of Binimetinib, a selective inhibitor of MEK1/2. This stable isotope retains the inhibitory activity of its parent compound, exhibiting an IC50 of 12 nM against MEK. Binimetinib-d4 is primarily utilized in biological research to enable the study of MEK signaling pathways and the pharmacokinetics of MEK inhibitors. Its labeled form allows for enhanced detection and quantification in metabolic studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2890696-60-1
Applications	Stable Isotope
Formula	C₁₇H₁₁D₄BrF₂N₄O₃
Molecular Weight	445.25
Synonyms	MEK162-d4; ARRY-162-d4; ARRY-438162-d4
SMILES	FC1=C(NC2=C(F)C(N=CN3C)=C3C=C2C(NOC([2H])([2H])C([2H])([2H])O)=O)C=CC(Br)=C1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.