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Pamapimod-d4

Stable Isotope

Pamapimod-d4 is a deuterium-labeled derivative of Pamapimod, a potent and selective inhibitor of p38 MAPK, exhibiting IC50 values of 14 nM and 480 nM for p38α and p38β, respectively. This compound specifically targets the p38 MAPK pathway and demonstrates no activity against p38δ or p38γ isoforms. Pamapimod-d4 is useful for research applications involving the modulation of inflammatory processes and holds potential in studying treatments for rheumatoid arthritis and other autoimmune diseases.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1246814-57-2
Applications	Stable Isotope
Formula	C₁₉H₁₆D₄F₂N₄O₄
Molecular Weight	410.41
SMILES	CN1C=2C(C=C(OC3=C(F)C=C(F)C=C3)C1=O)=CN=C(NC(CC(O)([2H])[2H])CC(O)([2H])[2H])N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.