Fig. 1 · Structure
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Ranolazine-d8 dihydrochloride
Stable Isotope
Ranolazine-d8 dihydrochloride is a deuterium-labeled analog of Ranolazine dihydrochloride, a compound primarily targeting the late phase of inward sodium current (INa) with an IC50 of 6 μM and IKr with an IC50 of 12 μM. This reagent is primarily utilized in research focused on cardiac physiology and pharmacology, particularly in studies of angina and arrhythmia. Additionally, Ranolazine-d8 serves as a partial fatty acid oxidation inhibitor, providing insights into metabolic modulation in cardiac tissues.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1219802-60-4 |
| Applications | Stable Isotope |
| Formula | C24H27D8Cl2N3O4 |
| Molecular Weight | 508.51 |
| Synonyms | CVT 303-dd8 dihydrochloride; RS 43285-d8 |
| SMILES | CC(C=CC=C1C)=C1NC(CN(C([2H])([2H])C2([2H])[2H])C([2H])([2H])C([2H])([2H])N2CC(O)COC3=C(C=CC=C3)OC)=O.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.