Fig. 1 · Structure
Documents & Downloads
Vismodegib-d4
Stable Isotope
Vismodegib-d4 is a deuterated form of Vismodegib, a potent inhibitor of the hedgehog signaling pathway. It exhibits a remarkable IC50 of 3 nM, demonstrating its efficacy in modulating this critical pathway. Additionally, Vismodegib influences P-glycoprotein and ABCG2 transporters with IC50 values of 3.0 μM and 1.4 μM, respectively. This compound is valuable for pharmacokinetic studies and research applications involving hedgehog pathway modulation.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1450990-33-6 |
| Applications | Stable Isotope |
| Formula | C19H10D4Cl2N2O3S |
| Molecular Weight | 425.32 |
| SMILES | ClC1=CC=C(C=C1C2=C([2H])C([2H])=C([2H])C([2H])=N2)NC(C3=C(Cl)C=C(S(C)(=O)=O)C=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.