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Retinoic acid-d3

Stable Isotope

Retinoic acid-d3 is a deuterium-labeled derivative of retinoic acid that serves as a stable isotope for research applications. Retinoic acid, a key metabolite of vitamin A, is crucial for processes such as cell growth, differentiation, and organogenesis. It functions as a natural agonist of retinoic acid receptors (RARα, RARβ, RARγ) with an IC50 of approximately 14 nM and demonstrates binding to PPARβ/δ with a Kd of 17 nM. Additionally, retinoic acid acts as an inhibitor of the transcription factor Nrf2 by activating retinoic acid receptor alpha, making it valuable for studies related to gene expression and cellular signaling.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	154461-49-1
Applications	Stable Isotope
Formula	C₂₀H₂₅D₃O₂
Molecular Weight	303.45
Synonyms	Vitamin A acid-d3; all-trans-Retinoic acid-d3; ATRA-d3
SMILES	CC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C([2H])([2H])[2H])C)=C\C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.