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Quetiapine-d4-1 fumarate

Stable Isotope

Quetiapine-d4-1 fumarate is a deuterated analogue of Quetiapine, specifically designed to enhance analytical precision in research applications. As a serotonin (5-HT) receptor agonist, it exhibits a pEC50 of 4.77 at the human 5-HT1A receptor and acts as a dopamine receptor antagonist with a pIC50 of 6.33 for the human D2 receptor. Quetiapine-d4-1 fumarate demonstrates moderate to high affinity for several key receptors, including D2, 5-HT1A, 5-HT2A, and 5-HT2C, making it suitable for studies in neuropharmacology, particularly in exploring antidepressant and anxiolytic effects.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2820085-77-4
Applications	Stable Isotope
Formula	C₂₁H₂₁D₄N₃O₂S.1/2C₄H₄O₄
Molecular Weight	445.57
SMILES	OC([2H])([2H])C([2H])([2H])OCCN(CC1)CCN1C2=NC3=CC=CC=C3SC4=C2C=CC=C4.O=C(O)/C=C/C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.