Clozapine-d3 is a deuterium-labeled derivative of Clozapine, primarily targeting neuroreceptors involved in psychiatric disorders. This compound exhibits high affinity as a dopamine D2 receptor antagonist with a Ki of 75 nM, while also inhibiting the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine-d3 acts as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM), making it valuable for investigations into schizophrenia and related neurochemical pathways.
Clozapine-d3 is a deuterium-labeled derivative of Clozapine, primarily targeting neuroreceptors involved in psychiatric disorders. This compound exhibits high affinity as a dopamine D2 receptor antagonist with a Ki of 75 nM, while also inhibiting the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Additionally, Clozapine-d3 acts as a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM), making it valuable for investigations into schizophrenia and related neurochemical pathways.
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